chr12 : 105,716,264 – 105,717,250
986 bp 52 TFs 1 linked gene
This 986 bp open chromatin element is linked to NUAK1 and is bound by 52 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
NUAK1 422.2 kb Distal Multiome+HiCAR
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr12:105,711,264 – 105,722,250
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
52 transcription factors
Source
Cell type
ARNT 1 dataset
ChIP A-549 GSE85352.ARNT.A-549 340 bp overlap
CDX2 1 dataset
Motif DE_36h DE_36h-CDX2_MA0465.3 8 bp overlap
CTCF 10 datasets
Motif DE_36h DE_36h-CTCF_MA1929.2 31 bp overlap
ChIP HAP1 GSE152721.CTCF.HAP1 257 bp overlap
ChIP HAP1_2kb GSE152721.CTCF.HAP1_2kb 163 bp overlap
ChIP HAP1_WT GSE126634.CTCF.HAP1_WT 286 bp overlap
ChIP HAP1_clone21 GSE152721.CTCF.HAP1_clone21 244 bp overlap
ChIP HAP1_clone21_CTCF-CRISPR GSE152721.CTCF.HAP1_clone21_CTCF-CRISPR 294 bp overlap
ChIP HAP1_clone21_CTCF-TSS-CRISPR_1 GSE152721.CTCF.HAP1_clone21_CTCF-TSS-CRISPR_1 200 bp overlap
ChIP HAP1_clone21_CTCF-TSS-CRISPR_2 GSE152721.CTCF.HAP1_clone21_CTCF-TSS-CRISPR_2 346 bp overlap
ChIP HAP1_clone21_TSS-CRISPR GSE152721.CTCF.HAP1_clone21_TSS-CRISPR 276 bp overlap
ChIP esophagus_squamous-epithelium ENCSR838RUX.CTCF.esophagus_squamous-epithelium 129 bp overlap
E2F1 2 datasets
Motif DE_36h DE_36h-E2F1_MA0024.3 12 bp overlap
Motif DE_60h DE_60h-E2F1_MA0024.3 12 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 965 bp overlap
ESRRB 3 datasets
Motif DE_36h DE_36h-ESRRB_MA0141.4 10 bp overlap
Motif DE_48h DE_48h-ESRRB_MA0141.4 10 bp overlap
Motif DE_60h DE_60h-ESRRB_MA0141.4 10 bp overlap
ETS1 1 dataset
ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 248 bp overlap
EZH2 3 datasets
ChIP HCT-116 ENCSR046HGP.EZH2.HCT-116 359 bp overlap
ChIP RH30_DMSO GSE85169.EZH2.RH30_DMSO 216 bp overlap
ChIP THP-1 GSE135024.EZH2.THP-1 466 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 908 bp overlap
ChIP DE DE-FOXA2-2 925 bp overlap
GATA4 4 datasets
ChIP DE DE-GATA4-1 935 bp overlap
ChIP DE DE-GATA4-2 986 bp overlap
Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap
Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap
GATA6 9 datasets
ChIP DE DE-GATA6-1 986 bp overlap
ChIP DE DE-GATA6-2 986 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 790 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 782 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 754 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 804 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 797 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 772 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 947 bp overlap
JUN 4 datasets
ChIP DE_D1 S08-DE-d1-JUN-exp1 593 bp overlap
ChIP DE_D1 S40-DE-d1-JUN-exp2 702 bp overlap
ChIP DE_D2 S02-DE-d2-JUN-exp1 311 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 701 bp overlap
MEF2A 1 dataset
Motif DE_36h DE_36h-MEF2A_MA0052.5 10 bp overlap
MEF2B 1 dataset
Motif DE_36h DE_36h-MEF2B_MA0660.1 12 bp overlap
MEF2C 1 dataset
Motif DE_36h DE_36h-MEF2C_MA0497.2 11 bp overlap
MEF2D 1 dataset
Motif DE_36h DE_36h-MEF2D_MA0773.1 12 bp overlap
MGA::EVX1 2 datasets
Motif DE_36h DE_36h-MGAEVX1_MA1960.2 11 bp overlap
Motif DE_60h DE_60h-MGAEVX1_MA1960.2 11 bp overlap
NANOG 1 dataset
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 187 bp overlap
NEUROD1 4 datasets
ChIP D283-Med GSE92582.NEUROD1.D283-Med 217 bp overlap
ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 115 bp overlap
ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 192 bp overlap
ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 170 bp overlap
NR5A1 3 datasets
Motif DE_36h DE_36h-NR5A1_MA1540.3 12 bp overlap
Motif DE_48h DE_48h-NR5A1_MA1540.3 12 bp overlap
Motif DE_60h DE_60h-NR5A1_MA1540.3 12 bp overlap
Nr5A2 6 datasets
Motif DE_36h DE_36h-Nr5A2_MA0505.3 9 bp overlap
Motif DE_36h DE_36h-Nr5A2_MA0505.3 9 bp overlap
Motif DE_48h DE_48h-Nr5A2_MA0505.3 9 bp overlap
Motif DE_48h DE_48h-Nr5A2_MA0505.3 9 bp overlap
Motif DE_60h DE_60h-Nr5A2_MA0505.3 9 bp overlap
Motif DE_60h DE_60h-Nr5A2_MA0505.3 9 bp overlap
PAX3-FOXO1 1 dataset
ChIP RH4 GSE140115.PAX3-FOXO1.RH4 205 bp overlap
PBX2 1 dataset
Motif DE_36h DE_36h-PBX2_MA1113.3 9 bp overlap
POU5F1 1 dataset
ChIP DE_D1 DED1-OCT4_Batch_II 254 bp overlap
Plagl1 1 dataset
Motif DE_36h DE_36h-Plagl1_MA1615.2 8 bp overlap
Prdm15 1 dataset
Motif DE_36h DE_36h-Prdm15_MA1616.2 11 bp overlap
RAD21 3 datasets
ChIP HAP1 GSE152721.RAD21.HAP1 319 bp overlap
ChIP HAP1_CTCF GSE126634.RAD21.HAP1_CTCF 422 bp overlap
ChIP HAP1_clone25 GSE152721.RAD21.HAP1_clone25 137 bp overlap
RBPJ 5 datasets
Motif DE_36h DE_36h-RBPJ_MA1116.2 6 bp overlap
Motif DE_36h DE_36h-RBPJ_MA1116.2 6 bp overlap
Motif DE_36h DE_36h-RBPJ_MA1116.2 6 bp overlap
Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap
Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap
SMAD2 2 datasets
ChIP endoderm GSE29422.SMAD2.endoderm 142 bp overlap
ChIP endoderm GSE29422.SMAD2.endoderm 289 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 972 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 816 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 800 bp overlap
SMAD2_3 5 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 759 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 736 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 748 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 894 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 878 bp overlap
SMAD3 2 datasets
ChIP endoderm GSE29422.SMAD3.endoderm 171 bp overlap
ChIP endoderm GSE29422.SMAD3.endoderm 201 bp overlap
SMAD4 2 datasets
ChIP endoderm GSE29422.SMAD4.endoderm 140 bp overlap
ChIP endoderm GSE29422.SMAD4.endoderm 238 bp overlap
SMARCC1 2 datasets
ChIP DE_D1 S15-DE-d1-BAF155-exp1 315 bp overlap
ChIP hiPSC GSE124903.SMARCC1.hiPSC 175 bp overlap
SMC1 1 dataset
ChIP HAP1_WaplKO-33_SCC4KO GSE94992.SMC1.HAP1_WaplKO-33_SCC4KO 238 bp overlap
SMC3 1 dataset
ChIP HeLa-Kyoto_PDS5-depleted GSE102884.SMC3.HeLa-Kyoto_PDS5-depleted 325 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 933 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 986 bp overlap
T 2 datasets
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 407 bp overlap
ChIP H9_MESODERM GSE60606.T.H9_MESODERM 280 bp overlap
TBP 1 dataset
Motif DE_36h DE_36h-TBP_MA0108.3 7 bp overlap
TBX18 2 datasets
Motif DE_36h DE_36h-TBX18_MA1565.2 9 bp overlap
Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap
TFAP2B 3 datasets
Motif DE_36h DE_36h-TFAP2B_MA0812.2 9 bp overlap
Motif DE_48h DE_48h-TFAP2B_MA0812.2 9 bp overlap
Motif DE_60h DE_60h-TFAP2B_MA0812.2 9 bp overlap
Tbx6 2 datasets
Motif DE_36h DE_36h-Tbx6_MA1567.3 9 bp overlap
Motif DE_60h DE_60h-Tbx6_MA1567.3 9 bp overlap
ZNF189 2 datasets
ChIP HEK293 ENCFF638TIB 501 bp overlap
ChIP HEK293 ENCSR163RYW.ZNF189.HEK293 389 bp overlap
ZNF317 1 dataset
Motif DE_36h DE_36h-ZNF317_MA1593.2 8 bp overlap
ZNF354C 3 datasets
Motif DE_36h DE_36h-ZNF354C_MA0130.1 6 bp overlap
Motif DE_60h DE_60h-ZNF354C_MA0130.1 6 bp overlap
Motif DE_72h DE_72h-ZNF354C_MA0130.1 6 bp overlap
ZNF417 2 datasets
Motif DE_36h DE_36h-ZNF417_MA1727.2 7 bp overlap
Motif DE_60h DE_60h-ZNF417_MA1727.2 7 bp overlap
ZNF418 1 dataset
Motif DE_36h DE_36h-ZNF418_MA1980.1 15 bp overlap
ZNF528 1 dataset
ChIP HEK293 GSE76494.ZNF528.HEK293 420 bp overlap
ZNF574 1 dataset
Motif DE_36h DE_36h-ZNF574_MA1982.2 14 bp overlap
ZNF768 4 datasets
Motif DE_36h DE_36h-ZNF768_MA1731.2 9 bp overlap
Motif DE_36h DE_36h-ZNF768_MA1731.2 9 bp overlap
Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap
Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap
Zfp961 2 datasets
Motif DE_36h DE_36h-Zfp961_MA2126.1 8 bp overlap
Motif DE_60h DE_60h-Zfp961_MA2126.1 8 bp overlap
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