chr1:108,685,537–108,686,147

chr1 : 108,685,537 – 108,686,147

610 bp 57 TFs 8 linked genes

This 610 bp open chromatin element is linked to 8 target genes and is bound by 57 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000290126		6.0 kb	Proximal	Proximity
PRPF38B		6.2 kb	Proximal	Proximity
HENMT1		24.8 kb	Distal	Multiome
STXBP3		60.8 kb	Distal	Multiome
EEIG2		125.8 kb	Distal	Multiome
GPSM2		191.1 kb	Distal	Multiome
AKNAD1		277.6 kb	Distal	Multiome
CLCC1		277.6 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

57 transcription factors

ASCL1 4 datasets

Motif DE_60h DE_60h-ASCL1_MA1631.2 9 bp overlap

Motif DE_60h DE_60h-ASCL1_MA1631.2 9 bp overlap

ChIP NCI-H2107 GSE69394.ASCL1.NCI-H2107 158 bp overlap

ChIP SCLC_ASCLP GSE61197.ASCL1.SCLC_ASCLP 205 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 357 bp overlap

ChIP K562 ENCFF921JQW 304 bp overlap

CASZ1 1 dataset

ChIP rhabdomyosarcoma_Trametinib GSE126143.CASZ1.rhabdomyosarcoma_Trametinib 228 bp overlap

ChIP RH5 GSE155861.CHD4.RH5 251 bp overlap

FERD3L 2 datasets

Motif DE_60h DE_60h-FERD3L_MA1485.1 14 bp overlap

Motif DE_72h DE_72h-FERD3L_MA1485.1 14 bp overlap

FEZF2 2 datasets

Motif DE_60h DE_60h-FEZF2_MA2341.1 8 bp overlap

Motif DE_72h DE_72h-FEZF2_MA2341.1 8 bp overlap

FIGLA 4 datasets

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

FOXA1 1 dataset

ChIP MCF-7_TNF GSE59530.FOXA1.MCF-7_TNF 136 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 533 bp overlap

ChIP DE DE-FOXA2-2 487 bp overlap

GATA1 2 datasets

Motif DE_60h DE_60h-GATA1_MA0035.5 7 bp overlap

Motif DE_72h DE_72h-GATA1_MA0035.5 7 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 610 bp overlap

ChIP DE DE-GATA4-2 610 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 262 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 610 bp overlap

ChIP DE DE-GATA6-2 610 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 450 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 487 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 320 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 322 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 450 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 535 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 527 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 240 bp overlap

HDAC2 1 dataset

ChIP RH4_Entinostat-6H GSE116344.HDAC2.RH4_Entinostat-6H 298 bp overlap

HDAC3 1 dataset

ChIP RH4_DMSO-6H GSE116344.HDAC3.RH4_DMSO-6H 219 bp overlap

Motif DE_60h DE_60h-HES6_MA1493.1 10 bp overlap

HOXC13 2 datasets

Motif DE_60h DE_60h-HOXC13_MA0907.2 9 bp overlap

Motif DE_72h DE_72h-HOXC13_MA0907.2 9 bp overlap

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 181 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 173 bp overlap

MEIS1 2 datasets

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA1639.2 9 bp overlap

MEIS2 2 datasets

Motif DE_60h DE_60h-MEIS2_MA0774.1 8 bp overlap

Motif DE_60h DE_60h-MEIS2_MA1640.2 9 bp overlap

MEIS3 1 dataset

Motif DE_60h DE_60h-MEIS3_MA0775.2 7 bp overlap

Motif DE_60h DE_60h-MYB_MA0100.4 6 bp overlap

Motif DE_72h DE_72h-MYB_MA0100.4 6 bp overlap

ChIP NCI-H2171 GSE36354.MYC.NCI-H2171 175 bp overlap

MYOD1 7 datasets

Motif DE_60h DE_60h-MYOD1_MA0499.3 9 bp overlap

Motif DE_60h DE_60h-MYOD1_MA0499.3 9 bp overlap

Motif DE_60h DE_60h-MYOD1_MA0499.3 9 bp overlap

Motif DE_72h DE_72h-MYOD1_MA0499.3 9 bp overlap

ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 606 bp overlap

ChIP SMS-CTR GSE137168.MYOD1.SMS-CTR 546 bp overlap

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 161 bp overlap

Mecom 2 datasets

Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap

Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap

NANOG 2 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 342 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 146 bp overlap

Motif DE_60h DE_60h-PBX2_MA1113.3 9 bp overlap

PDX1 2 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 317 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 202 bp overlap

PKNOX1 2 datasets

ChIP HEK293T ENCFF174WDB 391 bp overlap

ChIP HEK293T ENCSR233FAG.PKNOX1.HEK293T 231 bp overlap

POU2F3 1 dataset

ChIP NCI-H1048 GSE115123.POU2F3.NCI-H1048 239 bp overlap

Ptf1A 3 datasets

Motif DE_60h DE_60h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_60h DE_60h-Ptf1A_MA1620.2 8 bp overlap

Motif DE_72h DE_72h-Ptf1A_MA1620.2 8 bp overlap

RBBP4 1 dataset

ChIP RH5 GSE155861.RBBP4.RH5 179 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 135 bp overlap

Motif DE_60h DE_60h-Rfx6_MA1724.2 9 bp overlap

SCRT1 5 datasets

Motif DE_60h DE_60h-SCRT1_MA0743.3 10 bp overlap

Motif DE_60h DE_60h-SCRT1_MA0743.3 10 bp overlap

Motif DE_72h DE_72h-SCRT1_MA0743.3 10 bp overlap

ChIP HEK293 ENCFF513YVP 282 bp overlap

ChIP HEK293 ENCSR605MGM.SCRT1.HEK293 362 bp overlap

SCRT2 4 datasets

Motif DE_60h DE_60h-SCRT2_MA0744.3 10 bp overlap

Motif DE_60h DE_60h-SCRT2_MA0744.3 10 bp overlap

Motif DE_72h DE_72h-SCRT2_MA0744.3 10 bp overlap

ChIP HEK293 ENCFF711QQB 463 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 610 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 503 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 379 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 341 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 399 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 272 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 610 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 596 bp overlap

SNAI2 7 datasets

Motif DE_60h DE_60h-SNAI2_MA0745.3 8 bp overlap

Motif DE_60h DE_60h-SNAI2_MA0745.3 8 bp overlap

Motif DE_72h DE_72h-SNAI2_MA0745.3 8 bp overlap

ChIP SMS-CTR GSE137168.SNAI2.SMS-CTR 241 bp overlap

ChIP SMS-CTR_D48 GSE137168.SNAI2.SMS-CTR_D48 264 bp overlap

ChIP SMS-CTR_T48 GSE137168.SNAI2.SMS-CTR_T48 233 bp overlap

ChIP SMS-CTR_shSNAI2 GSE137168.SNAI2.SMS-CTR_shSNAI2 188 bp overlap

SNAI3 1 dataset

Motif DE_60h DE_60h-SNAI3_MA1559.2 9 bp overlap

SOX10 2 datasets

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 491 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 580 bp overlap

ChIP HEK293 GSE76494.SP4.HEK293 218 bp overlap

Motif DE_60h DE_60h-TBP_MA0108.3 7 bp overlap

TCF12 3 datasets

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 263 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 153 bp overlap

ChIP NPC GSE154479.TCF3.NPC 346 bp overlap

TCF4 2 datasets

Motif DE_60h DE_60h-TCF4_MA0830.3 8 bp overlap

Motif DE_60h DE_60h-TCF4_MA0830.3 8 bp overlap

TP53 2 datasets

Motif DE_60h DE_60h-TP53_MA0106.3 18 bp overlap

Motif DE_72h DE_72h-TP53_MA0106.3 18 bp overlap

TP63 2 datasets

Motif DE_60h DE_60h-TP63_MA0525.2 18 bp overlap

Motif DE_72h DE_72h-TP63_MA0525.2 18 bp overlap

ZBTB7C 2 datasets

Motif DE_60h DE_60h-ZBTB7C_MA0695.2 8 bp overlap

Motif DE_72h DE_72h-ZBTB7C_MA0695.2 8 bp overlap

ZEB1 4 datasets

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ChIP HEK293 ENCFF033NQQ 119 bp overlap

ZNF143 1 dataset

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 145 bp overlap

ZNF324 1 dataset

Motif DE_60h DE_60h-ZNF324_MA1977.2 14 bp overlap

ZNF768 2 datasets

Motif DE_60h DE_60h-ZNF768_MA1731.2 9 bp overlap

Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap