This gene encodes a protein which contains a domain found in an AT-hook-containing transcription factor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for AKNAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKNAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKNAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:108,685,537–108,686,147 | 277.6 kb | Distal (>10kb) Multiome | 57 | |
| chr1:108,691,720–108,693,647 | 271.1 kb | Distal (>10kb) Multiome | 985 | |
| chr1:108,746,190–108,747,539 | 216.8 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:108,842,454–108,843,162 | 120.8 kb | Distal (>10kb) Multiome | 142 | |
| chr1:108,845,269–108,845,935 | 117.9 kb | Distal (>10kb) Multiome | 30 | |
| chr1:108,861,842–108,862,840 | 101.1 kb | Distal (>10kb) Multiome | 54 | |
| chr1:108,876,465–108,877,492 | 86.5 kb | Distal (>10kb) Multiome | 823 | |
| chr1:108,962,714–108,962,890 | 593 bp | At TSS | 115 | |
| chr1:108,963,024–108,963,620 | 84 bp | At TSS Multiome | 906 | |
| chr1:109,041,106–109,042,646 | 78.7 kb | Distal (>10kb) Multiome | 792 | |
| chr1:109,075,733–109,076,324 | 112.6 kb | Distal (>10kb) Multiome | 864 | |
| chr1:109,090,360–109,091,274 | 127.3 kb | Distal (>10kb) Multiome | 1016 | |
| chr1:109,099,660–109,100,771 | 136.7 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:109,112,499–109,113,189 | 149.4 kb | Distal (>10kb) Multiome | 536 | |
| chr1:109,213,499–109,214,619 | 250.4 kb | Distal (>10kb) Multiome | 770 | |
| chr1:109,229,475–109,230,215 | 266.4 kb | Distal (>10kb) Multiome | 221 | |
| chr1:109,249,055–109,250,364 | 286.1 kb | Distal (>10kb) Multiome | 527 | |
| chr1:109,263,250–109,264,042 | 300.2 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the AKNAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.