Enables chloride channel activity. Involved in endoplasmic reticulum calcium ion homeostasis. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. Implicated in retinitis pigmentosa 32. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CLCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:108,660,822–108,661,680 | 302.2 kb | Distal (>10kb) Multiome | 460 | |
| chr1:108,685,537–108,686,147 | 277.6 kb | Distal (>10kb) Multiome | 57 | |
| chr1:108,691,720–108,693,647 | 271.1 kb | Distal (>10kb) Multiome | 985 | |
| chr1:108,746,190–108,747,539 | 216.8 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:108,828,188–108,828,798 | 135.1 kb | Distal (>10kb) Multiome | 359 | |
| chr1:108,842,454–108,843,162 | 120.8 kb | Distal (>10kb) Multiome | 142 | |
| chr1:108,845,269–108,845,935 | 117.9 kb | Distal (>10kb) Multiome | 30 | |
| chr1:108,861,842–108,862,840 | 101.1 kb | Distal (>10kb) Multiome | 54 | |
| chr1:108,876,465–108,877,492 | 86.5 kb | Distal (>10kb) Multiome | 823 | |
| chr1:108,947,887–108,948,155 | 3.9 kb | Proximal (<10kb) | 54 | |
| chr1:108,962,714–108,962,890 | 598 bp | At TSS | 115 | |
| chr1:108,963,024–108,963,620 | 89 bp | At TSS Multiome | 906 | |
| chr1:109,041,106–109,042,646 | 78.7 kb | Distal (>10kb) Multiome | 792 | |
| chr1:109,075,733–109,076,324 | 112.6 kb | Distal (>10kb) Multiome | 864 | |
| chr1:109,090,360–109,091,274 | 127.3 kb | Distal (>10kb) Multiome | 1016 | |
| chr1:109,099,660–109,100,771 | 136.7 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:109,112,499–109,113,189 | 149.4 kb | Distal (>10kb) Multiome | 536 | |
| chr1:109,113,744–109,114,449 | 150.7 kb | Distal (>10kb) Multiome | 236 | |
| chr1:109,213,499–109,214,619 | 250.4 kb | Distal (>10kb) Multiome | 770 | |
| chr1:109,229,475–109,230,215 | 266.4 kb | Distal (>10kb) Multiome | 221 | |
| chr1:109,240,604–109,241,116 | 277.5 kb | Distal (>10kb) Multiome | 391 | |
| chr1:109,249,055–109,250,364 | 286.0 kb | Distal (>10kb) Multiome | 527 | |
| chr1:109,263,250–109,264,042 | 300.2 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the CLCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.