The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for GPSM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPSM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPSM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:108,660,822–108,661,680 | 215.7 kb | Distal (>10kb) Multiome | 460 | |
| chr1:108,685,537–108,686,147 | 191.1 kb | Distal (>10kb) Multiome | 57 | |
| chr1:108,691,720–108,693,647 | 184.6 kb | Distal (>10kb) Multiome | 985 | |
| chr1:108,746,190–108,747,539 | 130.3 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:108,828,188–108,828,798 | 48.6 kb | Distal (>10kb) Multiome | 359 | |
| chr1:108,842,454–108,843,162 | 34.3 kb | Distal (>10kb) Multiome | 142 | |
| chr1:108,845,269–108,845,935 | 31.4 kb | Distal (>10kb) Multiome | 30 | |
| chr1:108,861,842–108,862,840 | 14.6 kb | Distal (>10kb) Multiome | 54 | |
| chr1:108,876,465–108,877,492 | 44 bp | At TSS Multiome | 823 | |
| chr1:108,877,991–108,878,337 | 1.0 kb | Proximal (<10kb) | 89 | |
| chr1:108,963,024–108,963,620 | 86.4 kb | Distal (>10kb) Multiome | 906 | |
| chr1:109,041,106–109,042,646 | 165.2 kb | Distal (>10kb) Multiome | 792 | |
| chr1:109,075,733–109,076,324 | 199.1 kb | Distal (>10kb) Multiome | 864 | |
| chr1:109,090,360–109,091,274 | 213.8 kb | Distal (>10kb) Multiome | 1016 | |
| chr1:109,099,660–109,100,771 | 223.2 kb | Distal (>10kb) Multiome | 1149 | |
| chr1:109,112,499–109,113,189 | 235.9 kb | Distal (>10kb) Multiome | 536 | |
| chr1:109,113,744–109,114,449 | 237.2 kb | Distal (>10kb) Multiome | 236 |
Genomic view of the GPSM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.