Enables small RNA 2'-O-methyltransferase activity. Involved in RNA methylation. Predicted to be located in P granule. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HENMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HENMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HENMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:108,533,494–108,534,081 | 127.3 kb | Distal (>10kb) Multiome | 360 | |
| chr1:108,559,314–108,561,269 | 101.0 kb | Distal (>10kb) Multiome | 794 | |
| chr1:108,660,822–108,661,680 | 175 bp | At TSS Multiome | 460 | |
| chr1:108,685,537–108,686,147 | 24.8 kb | Distal (>10kb) Multiome | 57 | |
| chr1:108,691,720–108,693,647 | 31.3 kb | Distal (>10kb) Multiome | 985 | |
| chr1:108,746,190–108,747,539 | 85.6 kb | Distal (>10kb) Multiome | 1013 | |
| chr1:108,828,188–108,828,798 | 167.3 kb | Distal (>10kb) Multiome | 359 | |
| chr1:108,842,454–108,843,162 | 181.6 kb | Distal (>10kb) Multiome | 142 | |
| chr1:108,845,269–108,845,935 | 184.6 kb | Distal (>10kb) Multiome | 30 | |
| chr1:108,861,842–108,862,840 | 201.4 kb | Distal (>10kb) Multiome | 54 | |
| chr1:108,876,465–108,877,492 | 216.0 kb | Distal (>10kb) Multiome | 823 |
Genomic view of the HENMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.