chr15 : 62,521,042 – 62,522,181

1,139 bp 67 TFs 1 linked gene

This 1.1 kb open chromatin element is linked to TLN2 and is bound by 67 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
TLN2		131.1 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

67 transcription factors

ASCL1 1 dataset

Motif DE_12h DE_12h-ASCL1_MA1631.2 9 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 423 bp overlap

BRD3 2 datasets

ChIP H-1_DE GSE126661.BRD3.H-1_DE 325 bp overlap

ChIP H-1_DE GSE126661.BRD3.H-1_DE 331 bp overlap

CTNNB1 1 dataset

ChIP hESC_YAP-_activinA_15h GSE99202.CTNNB1.hESC_YAP-_activinA_15h 409 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 264 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 141 bp overlap

FIGLA 1 dataset

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 529 bp overlap

ChIP DE DE-FOXA2-2 472 bp overlap

FOXE1 1 dataset

Motif DE_12h DE_12h-FOXE1_MA1487.3 12 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_12h DE_12h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 776 bp overlap

ChIP DE DE-GATA4-2 738 bp overlap

GATA6 8 datasets

ChIP DE DE-GATA6-1 496 bp overlap

ChIP DE DE-GATA6-2 572 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 478 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 638 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 741 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 305 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 659 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 500 bp overlap

IRF1 1 dataset

ChIP K-562_EPZ GSE129380.IRF1.K-562_EPZ 421 bp overlap

JUN 4 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 446 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 619 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 612 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 450 bp overlap

MEIS1 1 dataset

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

MSC 1 dataset

Motif DE_12h DE_12h-MSC_MA0665.1 10 bp overlap

NANOG 6 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 527 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 198 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 782 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 384 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 360 bp overlap

ChIP hESC GSE18292.NANOG.hESC 96 bp overlap

NEUROD1 4 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 419 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 248 bp overlap

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 214 bp overlap

ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 236 bp overlap

NR2C2 1 dataset

Motif DE_12h DE_12h-NR2C2_MA0504.2 14 bp overlap

NR2F1 1 dataset

Motif DE_12h DE_12h-NR2F1_MA1537.2 13 bp overlap

NR6A1 1 dataset

Motif DE_12h DE_12h-NR6A1_MA1541.2 14 bp overlap

Nr2f6 1 dataset

Motif DE_12h DE_12h-Nr2f6_MA0677.2 13 bp overlap

PKNOX1 1 dataset

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 158 bp overlap

PKNOX2 1 dataset

Motif DE_12h DE_12h-PKNOX2_MA0783.1 12 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_12h DE_12h-POU2F1SOX2_MA1962.1 17 bp overlap

POU2F3 1 dataset

ChIP NCI-H1048 GSE115123.POU2F3.NCI-H1048 212 bp overlap

POU4F2 1 dataset

Motif DE_12h DE_12h-POU4F2_MA0683.2 15 bp overlap

POU5F1 7 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 369 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 456 bp overlap

ChIP NCCIT GSE36134.POU5F1.NCCIT 484 bp overlap

ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 754 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 371 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 395 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 260 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 521 bp overlap

PPARD 1 dataset

Motif DE_12h DE_12h-PPARD_MA1550.2 14 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_12h DE_12h-Pou5f1Sox2_MA0142.1 15 bp overlap

RAD21 1 dataset

ChIP HAP1 GSE152721.RAD21.HAP1 194 bp overlap

RARA 1 dataset

Motif DE_12h DE_12h-RARA_MA0729.1 18 bp overlap

RXRA::VDR 1 dataset

Motif DE_12h DE_12h-RXRAVDR_MA0074.1 15 bp overlap

RXRB 1 dataset

Motif DE_12h DE_12h-RXRB_MA0855.1 14 bp overlap

RXRG 1 dataset

Motif DE_12h DE_12h-RXRG_MA0856.1 14 bp overlap

Rxra 1 dataset

Motif DE_12h DE_12h-Rxra_MA0512.2 14 bp overlap

SMAD2 3 datasets

ChIP endoderm GSE29422.SMAD2.endoderm 271 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 711 bp overlap

ChIP hESC_activinA_15h GSE99202.SMAD2.hESC_activinA_15h 298 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 1139 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 971 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 1034 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 927 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 872 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 1009 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 658 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 557 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 169 bp overlap

SMARCA4 2 datasets

ChIP hiPSC GSE124903.SMARCA4.hiPSC 247 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 202 bp overlap

SMARCB1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 302 bp overlap

SMARCC1 4 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 245 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 650 bp overlap

ChIP hiPSC GSE124903.SMARCC1.hiPSC 203 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 374 bp overlap

SNAI1 1 dataset

Motif DE_12h DE_12h-SNAI1_MA1558.2 7 bp overlap

SNAI3 1 dataset

Motif DE_12h DE_12h-SNAI3_MA1559.2 9 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 378 bp overlap

SOX2 1 dataset

ChIP hiPSC GSE56567.SOX2.hiPSC 332 bp overlap

TBX1 1 dataset

Motif DE_12h DE_12h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_12h DE_12h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_12h DE_12h-TBX18_MA1565.2 9 bp overlap

TBX2 1 dataset

Motif DE_12h DE_12h-TBX2_MA0688.2 9 bp overlap

TBX21 1 dataset

Motif DE_12h DE_12h-TBX21_MA0690.3 10 bp overlap

TBX3 1 dataset

Motif DE_12h DE_12h-TBX3_MA1566.3 9 bp overlap

TBX4 1 dataset

Motif DE_12h DE_12h-TBX4_MA0806.1 8 bp overlap

TBX5 1 dataset

Motif DE_12h DE_12h-TBX5_MA0807.1 8 bp overlap

TCF12 1 dataset

Motif DE_12h DE_12h-TCF12_MA1648.2 7 bp overlap

TCF3 1 dataset

Motif DE_12h DE_12h-TCF3_MA0522.4 7 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 391 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 243 bp overlap

TGIF1 1 dataset

Motif DE_12h DE_12h-TGIF1_MA0796.1 12 bp overlap

TGIF2 1 dataset

Motif DE_12h DE_12h-TGIF2_MA0797.1 12 bp overlap

THRB 1 dataset

Motif DE_12h DE_12h-THRB_MA1574.2 13 bp overlap

TP53 1 dataset

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 289 bp overlap

VEZF1 1 dataset

Motif DE_12h DE_12h-VEZF1_MA1578.2 6 bp overlap

ZEB1 1 dataset

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

ZFP57 1 dataset

ChIP hESC GSE115387.ZFP57.hESC 517 bp overlap

ZNF768 2 datasets

Motif DE_12h DE_12h-ZNF768_MA1731.2 9 bp overlap

Motif DE_24h DE_24h-ZNF768_MA1731.2 9 bp overlap