chr2 : 128,532,910 – 128,533,444

534 bp 75 TFs 1 linked gene

This 534 bp open chromatin element is linked to HS6ST1 and is bound by 75 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
HS6ST1		214.4 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

75 transcription factors

ATOH7 1 dataset

Motif DE_60h DE_60h-ATOH7_MA1468.1 10 bp overlap

Ascl2 1 dataset

Motif DE_60h DE_60h-Ascl2_MA0816.1 10 bp overlap

BCL6 1 dataset

Motif DE_48h DE_48h-BCL6_MA0463.3 13 bp overlap

BCOR 1 dataset

ChIP B-cell_GERMINAL_CENTER GSE43350.BCOR.B-cell_GERMINAL_CENTER 136 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 281 bp overlap

EOMES 2 datasets

Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 222 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_48h DE_48h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA1 1 dataset

Motif DE_60h DE_60h-FOXA1_MA0148.5 8 bp overlap

FOXB1 1 dataset

Motif DE_60h DE_60h-FOXB1_MA0845.1 11 bp overlap

FOXC1 1 dataset

Motif DE_60h DE_60h-FOXC1_MA0032.2 11 bp overlap

FOXC2 1 dataset

Motif DE_60h DE_60h-FOXC2_MA0846.2 11 bp overlap

FOXD2 1 dataset

Motif DE_60h DE_60h-FOXD2_MA0847.4 11 bp overlap

FOXD3 1 dataset

Motif DE_60h DE_60h-FOXD3_MA0041.3 14 bp overlap

FOXE1 1 dataset

Motif DE_60h DE_60h-FOXE1_MA1487.3 12 bp overlap

FOXF2 1 dataset

Motif DE_60h DE_60h-FOXF2_MA0030.2 9 bp overlap

FOXG1 1 dataset

Motif DE_60h DE_60h-FOXG1_MA0613.1 8 bp overlap

FOXH1 1 dataset

Motif DE_60h DE_60h-FOXH1_MA0479.2 8 bp overlap

FOXK1 1 dataset

Motif DE_60h DE_60h-FOXK1_MA0852.3 7 bp overlap

FOXK2 1 dataset

Motif DE_60h DE_60h-FOXK2_MA1103.3 7 bp overlap

FOXL1 1 dataset

Motif DE_60h DE_60h-FOXL1_MA0033.2 7 bp overlap

FOXO4 1 dataset

Motif DE_60h DE_60h-FOXO4_MA0848.1 7 bp overlap

FOXO6 1 dataset

Motif DE_60h DE_60h-FOXO6_MA0849.1 7 bp overlap

FOXP2 1 dataset

Motif DE_60h DE_60h-FOXP2_MA0593.2 9 bp overlap

FOXP3 1 dataset

Motif DE_60h DE_60h-FOXP3_MA0850.1 7 bp overlap

Foxf1 1 dataset

Motif DE_60h DE_60h-Foxf1_MA1606.2 7 bp overlap

Foxj2 1 dataset

Motif DE_60h DE_60h-Foxj2_MA0614.1 8 bp overlap

Foxj3 1 dataset

Motif DE_60h DE_60h-Foxj3_MA0851.2 9 bp overlap

Foxl2 1 dataset

Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap

Foxo1 1 dataset

Motif DE_60h DE_60h-Foxo1_MA0480.3 7 bp overlap

Foxo3 1 dataset

Motif DE_60h DE_60h-Foxo3_MA0157.4 7 bp overlap

Foxq1 1 dataset

Motif DE_60h DE_60h-Foxq1_MA0040.2 10 bp overlap

GATA1::TAL1 1 dataset

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 411 bp overlap

ChIP DE DE-GATA4-2 344 bp overlap

GATA6 1 dataset

ChIP DE DE-GATA6-1 310 bp overlap

HAND2 1 dataset

Motif DE_60h DE_60h-HAND2_MA1638.2 6 bp overlap

HNF1B 1 dataset

ChIP foregut GSE117136.HNF1B.foregut 389 bp overlap

MEIS1 3 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MGA 1 dataset

Motif DE_60h DE_60h-MGA_MA0801.1 8 bp overlap

MGA::EVX1 1 dataset

Motif DE_60h DE_60h-MGAEVX1_MA1960.2 11 bp overlap

Mecom 1 dataset

Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap

NEUROD1 1 dataset

Motif DE_60h DE_60h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 1 dataset

Motif DE_60h DE_60h-NEUROG2_MA0669.1 10 bp overlap

Neurod2 1 dataset

Motif DE_60h DE_60h-Neurod2_MA0668.3 8 bp overlap

OLIG1 1 dataset

Motif DE_60h DE_60h-OLIG1_MA0826.1 10 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_60h DE_60h-POU2F1SOX2_MA1962.1 17 bp overlap

POU3F3 1 dataset

Motif DE_60h DE_60h-POU3F3_MA0788.1 13 bp overlap

Ptf1A 1 dataset

Motif DE_60h DE_60h-Ptf1A_MA1618.2 9 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 197 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 534 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 402 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 383 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 307 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 344 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 327 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 534 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 478 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 419 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 372 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 513 bp overlap

Six3 3 datasets

Motif DE_48h DE_48h-Six3_MA0631.2 11 bp overlap

Motif DE_60h DE_60h-Six3_MA0631.2 11 bp overlap

Motif DE_72h DE_72h-Six3_MA0631.2 11 bp overlap

Smad4 1 dataset

Motif DE_48h DE_48h-Smad4_MA1153.2 7 bp overlap

Sox11 1 dataset

Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap

Sox17 1 dataset

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Sox6 1 dataset

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Sox7 1 dataset

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

TAL1::TCF3 1 dataset

Motif DE_60h DE_60h-TAL1TCF3_MA0091.2 10 bp overlap

TBR1 1 dataset

Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap

TBX1 1 dataset

Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap

TBX2 1 dataset

Motif DE_60h DE_60h-TBX2_MA0688.2 9 bp overlap

TBX20 1 dataset

Motif DE_60h DE_60h-TBX20_MA0689.1 11 bp overlap

TBX21 1 dataset

Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap

TBX3 1 dataset

Motif DE_60h DE_60h-TBX3_MA1566.3 9 bp overlap

TBX4 1 dataset

Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap

TBX5 1 dataset

Motif DE_60h DE_60h-TBX5_MA0807.1 8 bp overlap

Tbx6 1 dataset

Motif DE_60h DE_60h-Tbx6_MA1567.3 9 bp overlap

ZNF274 1 dataset

Motif DE_60h DE_60h-ZNF274_MA1592.2 12 bp overlap

ZNF652 3 datasets

Motif DE_48h DE_48h-ZNF652_MA1657.2 9 bp overlap

Motif DE_60h DE_60h-ZNF652_MA1657.2 9 bp overlap

Motif DE_72h DE_72h-ZNF652_MA1657.2 9 bp overlap

ZNF766 1 dataset

Motif DE_60h DE_60h-ZNF766_MA2098.1 9 bp overlap

ZSCAN29 1 dataset

Motif DE_60h DE_60h-ZSCAN29_MA1602.2 11 bp overlap