chr21 : 31,192,699 – 31,193,538

839 bp 73 TFs 1 linked gene

This 839 bp open chromatin element is linked to TIAM1 and is bound by 73 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
TIAM1		151.4 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

73 transcription factors

ASCL1 2 datasets

Motif DE_60h DE_60h-ASCL1_MA1100.3 8 bp overlap

Motif DE_60h DE_60h-ASCL1_MA1631.2 9 bp overlap

Ahr::Arnt 2 datasets

Motif DE_48h DE_48h-AhrArnt_MA0006.2 5 bp overlap

Motif DE_60h DE_60h-AhrArnt_MA0006.2 5 bp overlap

Ascl2 1 dataset

Motif DE_60h DE_60h-Ascl2_MA0816.1 10 bp overlap

BHLHE22 1 dataset

Motif DE_60h DE_60h-BHLHE22_MA1635.2 6 bp overlap

BRD4 1 dataset

ChIP hESC GSE33281.BRD4.hESC 61 bp overlap

Bcl11B 2 datasets

Motif DE_48h DE_48h-Bcl11B_MA1989.2 9 bp overlap

Motif DE_60h DE_60h-Bcl11B_MA1989.2 9 bp overlap

CDX2 2 datasets

Motif DE_48h DE_48h-CDX2_MA0465.3 8 bp overlap

Motif DE_60h DE_60h-CDX2_MA0465.3 8 bp overlap

CREBBP 1 dataset

ChIP MCF-7 ERP000901.CREBBP.MCF-7 115 bp overlap

CTCF 1 dataset

ChIP GSC23 GSE139416.CTCF.GSC23 213 bp overlap

DUX4 1 dataset

Motif DE_60h DE_60h-DUX4_MA0468.1 11 bp overlap

DUXA 1 dataset

Motif DE_60h DE_60h-DUXA_MA0884.2 13 bp overlap

Dux 1 dataset

Motif DE_60h DE_60h-Dux_MA0611.3 11 bp overlap

ERF::NHLH1 1 dataset

Motif DE_60h DE_60h-ERFNHLH1_MA1938.2 16 bp overlap

ERG 1 dataset

ChIP VCaP_ETOH GSE49091.ERG.VCaP_ETOH 116 bp overlap

EZH2 1 dataset

ChIP THP-1 GSE135024.EZH2.THP-1 233 bp overlap

FERD3L 1 dataset

Motif DE_60h DE_60h-FERD3L_MA1485.1 14 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 425 bp overlap

ChIP DE DE-FOXA2-2 349 bp overlap

FOXH1 2 datasets

Motif DE_48h DE_48h-FOXH1_MA0479.2 8 bp overlap

Motif DE_60h DE_60h-FOXH1_MA0479.2 8 bp overlap

Foxn1 2 datasets

Motif DE_48h DE_48h-Foxn1_MA1684.1 6 bp overlap

Motif DE_60h DE_60h-Foxn1_MA1684.1 6 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 306 bp overlap

ChIP DE DE-GATA4-2 500 bp overlap

GATA6 5 datasets

ChIP DE DE-GATA6-1 397 bp overlap

ChIP DE DE-GATA6-2 412 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 397 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 341 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 423 bp overlap

GLI3 2 datasets

Motif DE_48h DE_48h-GLI3_MA1491.3 15 bp overlap

Motif DE_60h DE_60h-GLI3_MA1491.3 15 bp overlap

HDAC2 1 dataset

ChIP PC-3 GSE147455.HDAC2.PC-3 95 bp overlap

HIF1A 1 dataset

ChIP U2OS_DMOG GSE85096.HIF1A.U2OS_DMOG 183 bp overlap

Hand1 2 datasets

Motif DE_48h DE_48h-Hand1_MA2123.1 9 bp overlap

Motif DE_60h DE_60h-Hand1_MA2123.1 9 bp overlap

IRF1 1 dataset

ChIP HAEC_IL1b_4h GSE89970.IRF1.HAEC_IL1b_4h 139 bp overlap

ISL2 1 dataset

Motif DE_60h DE_60h-ISL2_MA0914.2 6 bp overlap

JUNB 1 dataset

ChIP Karpas-299 GSE151413.JUNB.Karpas-299 226 bp overlap

KLF1 2 datasets

Motif DE_48h DE_48h-KLF1_MA0493.3 8 bp overlap

Motif DE_60h DE_60h-KLF1_MA0493.3 8 bp overlap

KLF17 2 datasets

Motif DE_48h DE_48h-KLF17_MA1514.2 14 bp overlap

Motif DE_60h DE_60h-KLF17_MA1514.2 14 bp overlap

KLF2 2 datasets

Motif DE_48h DE_48h-KLF2_MA1515.2 8 bp overlap

Motif DE_60h DE_60h-KLF2_MA1515.2 8 bp overlap

KLF4 2 datasets

Motif DE_48h DE_48h-KLF4_MA0039.5 8 bp overlap

Motif DE_60h DE_60h-KLF4_MA0039.5 8 bp overlap

KLF5 2 datasets

Motif DE_48h DE_48h-KLF5_MA0599.1 10 bp overlap

Motif DE_60h DE_60h-KLF5_MA0599.1 10 bp overlap

KLF6 2 datasets

Motif DE_48h DE_48h-KLF6_MA1517.2 9 bp overlap

Motif DE_60h DE_60h-KLF6_MA1517.2 9 bp overlap

KLF9 2 datasets

Motif DE_48h DE_48h-KLF9_MA1107.3 11 bp overlap

Motif DE_60h DE_60h-KLF9_MA1107.3 11 bp overlap

MEIS1 2 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

MYOD1 1 dataset

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 218 bp overlap

MYOG 1 dataset

Motif DE_60h DE_60h-MYOG_MA0500.3 8 bp overlap

NHLH1 1 dataset

Motif DE_60h DE_60h-NHLH1_MA0048.3 9 bp overlap

NHLH2 1 dataset

Motif DE_60h DE_60h-NHLH2_MA1529.2 16 bp overlap

NOTCH3 2 datasets

ChIP TALL-1_DMSO GSE104261.NOTCH3.TALL-1_DMSO 179 bp overlap

ChIP TALL-1_GSI GSE104261.NOTCH3.TALL-1_GSI 178 bp overlap

NR4A1 2 datasets

Motif DE_48h DE_48h-NR4A1_MA1112.3 8 bp overlap

Motif DE_60h DE_60h-NR4A1_MA1112.3 8 bp overlap

NR4A2 2 datasets

Motif DE_48h DE_48h-NR4A2_MA0160.3 8 bp overlap

Motif DE_60h DE_60h-NR4A2_MA0160.3 8 bp overlap

Neurod2 1 dataset

Motif DE_60h DE_60h-Neurod2_MA1993.2 6 bp overlap

Olig2 1 dataset

Motif DE_60h DE_60h-Olig2_MA1997.2 6 bp overlap

PAX9 1 dataset

Motif DE_60h DE_60h-PAX9_MA0781.2 16 bp overlap

POU2F2 1 dataset

ChIP HNPC_UNDIF GSE74814.POU2F2.HNPC_UNDIF 126 bp overlap

REL 1 dataset

Motif DE_60h DE_60h-REL_MA0101.1 10 bp overlap

RELA 1 dataset

Motif DE_60h DE_60h-RELA_MA0107.1 10 bp overlap

Rarg 1 dataset

Motif DE_60h DE_60h-Rarg_MA0860.1 17 bp overlap

Runx1 2 datasets

Motif DE_48h DE_48h-Runx1_MA0002.3 9 bp overlap

Motif DE_60h DE_60h-Runx1_MA0002.3 9 bp overlap

SMAD2 2 datasets

Motif DE_48h DE_48h-SMAD2_MA1964.2 6 bp overlap

Motif DE_60h DE_60h-SMAD2_MA1964.2 6 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 690 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 536 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 414 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 407 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 339 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 615 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 564 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 202 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 310 bp overlap

SOX21 2 datasets

Motif DE_48h DE_48h-SOX21_MA0866.1 15 bp overlap

Motif DE_60h DE_60h-SOX21_MA0866.1 15 bp overlap

TCF3 1 dataset

ChIP RCH-ACV GSE85988.TCF3.RCH-ACV 306 bp overlap

TEAD4 2 datasets

Motif DE_48h DE_48h-TEAD4_MA0809.3 8 bp overlap

Motif DE_60h DE_60h-TEAD4_MA0809.3 8 bp overlap

THRA 1 dataset

Motif DE_60h DE_60h-THRA_MA1969.2 18 bp overlap

THRB 1 dataset

Motif DE_60h DE_60h-THRB_MA1576.2 18 bp overlap

TP63 1 dataset

ChIP breast-organoid GSE113909.TP63.breast-organoid 236 bp overlap

Tcf12 1 dataset

Motif DE_60h DE_60h-Tcf12_MA0521.3 6 bp overlap

Twist2 1 dataset

Motif DE_60h DE_60h-Twist2_MA0633.3 6 bp overlap

ZBTB7A 1 dataset

ChIP VCaP_FBS GSE123089.ZBTB7A.VCaP_FBS 243 bp overlap

ZNF143 1 dataset

ChIP FLP143HA_T0 GSE39263.ZNF143.FLP143HA_T0 149 bp overlap

ZNF418 1 dataset

Motif DE_60h DE_60h-ZNF418_MA1980.1 15 bp overlap

ZNF707 1 dataset

Motif DE_60h DE_60h-ZNF707_MA1715.1 15 bp overlap

ZNF778 1 dataset

ChIP HEK293T GSE78099.ZNF778.HEK293T 138 bp overlap

ZNF8 1 dataset

Motif DE_60h DE_60h-ZNF8_MA1718.1 20 bp overlap

Zfp335 1 dataset

Motif DE_60h DE_60h-Zfp335_MA2002.2 7 bp overlap

Zfp809 2 datasets

Motif DE_48h DE_48h-Zfp809_MA2125.1 9 bp overlap

Motif DE_60h DE_60h-Zfp809_MA2125.1 9 bp overlap

Zic2 1 dataset

Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap