chr20 : 43,977,883 – 43,978,419

536 bp 84 TFs 3 linked genes

This 536 bp open chromatin element is linked to TOX2, OSER1, and OSER1-DT and is bound by 84 transcription factors.

Linked Genes

3 genes

Gene	Dist. to TSS	Distance	Link type
TOX2	63.3 kb	Distal	Multiome
OSER1	232.6 kb	Distal	Multiome
OSER1-DT	232.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

84 transcription factors

ARNTL 1 dataset

ChIP U2OS_DMOG GSE85096.ARNTL.U2OS_DMOG 278 bp overlap

BHLHE22 2 datasets

Motif DE_24h DE_24h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_36h DE_36h-BHLHE22_MA1635.2 6 bp overlap

BRD4 2 datasets

ChIP MDA-MB-231_JQ1-neg_S_3f GSE136151.BRD4.MDA-MB-231_JQ1-neg_S_3f 147 bp overlap

ChIP MDA-MB-231_JQ1-neg_S_3f GSE136151.BRD4.MDA-MB-231_JQ1-neg_S_3f 53 bp overlap

Bach1::Mafk 2 datasets

Motif DE_24h DE_24h-Bach1Mafk_MA0591.2 12 bp overlap

Motif DE_36h DE_36h-Bach1Mafk_MA0591.2 12 bp overlap

CEBPD 1 dataset

Motif DE_36h DE_36h-CEBPD_MA0836.3 8 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF031ISE 251 bp overlap

ChIP BLaER1 ENCFF274GAT 96 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 378 bp overlap

ETV2 1 dataset

ChIP induced-endothelial-cell_Veh GSE123906.ETV2.induced-endothelial-cell_Veh 111 bp overlap

Elf5 1 dataset

Motif DE_36h DE_36h-Elf5_MA0136.4 8 bp overlap

FOXA2 1 dataset

ChIP DE DE-FOXA2-1 394 bp overlap

FOXH1 2 datasets

Motif DE_24h DE_24h-FOXH1_MA0479.2 8 bp overlap

Motif DE_36h DE_36h-FOXH1_MA0479.2 8 bp overlap

GATA2 1 dataset

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 536 bp overlap

ChIP DE DE-GATA4-2 465 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 343 bp overlap

GATA5 1 dataset

Motif DE_36h DE_36h-GATA5_MA0766.3 8 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 428 bp overlap

ChIP DE DE-GATA6-2 526 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 536 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 536 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 536 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 536 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 536 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 536 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 536 bp overlap

ChIP foregut GSE117136.GATA6.foregut 261 bp overlap

Gata3 1 dataset

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

HIF1A 1 dataset

ChIP U2OS_trough_DMSO GSE85096.HIF1A.U2OS_trough_DMSO 204 bp overlap

HLF 1 dataset

Motif DE_36h DE_36h-HLF_MA0043.4 9 bp overlap

IKZF1 1 dataset

ChIP K-562 ENCSR395HWC.IKZF1.K-562 189 bp overlap

IKZF2 1 dataset

Motif DE_36h DE_36h-IKZF2_MA2326.1 6 bp overlap

IRF4 1 dataset

Motif DE_36h DE_36h-IRF4_MA1419.2 14 bp overlap

IRF5 1 dataset

Motif DE_36h DE_36h-IRF5_MA1420.1 14 bp overlap

IRF8 1 dataset

Motif DE_36h DE_36h-IRF8_MA0652.2 13 bp overlap

JUN 3 datasets

ChIP DE_D1 S40-DE-d1-JUN-exp2 475 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 415 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 443 bp overlap

KLF9 2 datasets

Motif DE_24h DE_24h-KLF9_MA1107.3 11 bp overlap

Motif DE_36h DE_36h-KLF9_MA1107.3 11 bp overlap

MAF 4 datasets

Motif DE_24h DE_24h-MAF_MA1520.2 13 bp overlap

Motif DE_36h DE_36h-MAF_MA1520.2 13 bp overlap

MAF::NFE2 2 datasets

Motif DE_24h DE_24h-MAFNFE2_MA0501.2 11 bp overlap

Motif DE_36h DE_36h-MAFNFE2_MA0501.2 11 bp overlap

MAFA 2 datasets

Motif DE_24h DE_24h-MAFA_MA1521.2 13 bp overlap

Motif DE_36h DE_36h-MAFA_MA1521.2 13 bp overlap

MAFG::NFE2L1 2 datasets

Motif DE_24h DE_24h-MAFGNFE2L1_MA0089.3 11 bp overlap

Motif DE_36h DE_36h-MAFGNFE2L1_MA0089.3 11 bp overlap

MEIS1 3 datasets

Motif DE_24h DE_24h-MEIS1_MA0498.3 5 bp overlap

Motif DE_24h DE_24h-MEIS1_MA1639.2 9 bp overlap

Motif DE_36h DE_36h-MEIS1_MA1639.2 9 bp overlap

MSANTD3 2 datasets

Motif DE_24h DE_24h-MSANTD3_MA1523.2 7 bp overlap

Motif DE_36h DE_36h-MSANTD3_MA1523.2 7 bp overlap

NFATC1 1 dataset

ChIP HUVEC-C_VEGF GSE49428.NFATC1.HUVEC-C_VEGF 169 bp overlap

NFATC3 1 dataset

Motif DE_36h DE_36h-NFATC3_MA0625.3 6 bp overlap

NFATC4 1 dataset

Motif DE_36h DE_36h-NFATC4_MA1525.3 9 bp overlap

NFIL3 1 dataset

Motif DE_36h DE_36h-NFIL3_MA0025.3 9 bp overlap

NHLH1 2 datasets

Motif DE_24h DE_24h-NHLH1_MA0048.3 9 bp overlap

Motif DE_36h DE_36h-NHLH1_MA0048.3 9 bp overlap

Neurod2 2 datasets

Motif DE_24h DE_24h-Neurod2_MA1993.2 6 bp overlap

Motif DE_36h DE_36h-Neurod2_MA1993.2 6 bp overlap

Nfat5 1 dataset

Motif DE_36h DE_36h-Nfat5_MA0606.3 8 bp overlap

Nfatc1 1 dataset

Motif DE_36h DE_36h-Nfatc1_MA0624.3 6 bp overlap

Nfe2l2 2 datasets

Motif DE_24h DE_24h-Nfe2l2_MA0150.3 11 bp overlap

Motif DE_36h DE_36h-Nfe2l2_MA0150.3 11 bp overlap

ONECUT3 1 dataset

Motif DE_36h DE_36h-ONECUT3_MA0757.2 12 bp overlap

Olig2 2 datasets

Motif DE_24h DE_24h-Olig2_MA1997.2 6 bp overlap

Motif DE_36h DE_36h-Olig2_MA1997.2 6 bp overlap

PBX1 2 datasets

Motif DE_24h DE_24h-PBX1_MA0070.2 9 bp overlap

Motif DE_36h DE_36h-PBX1_MA0070.2 9 bp overlap

PHIP 1 dataset

ChIP HCT-116_MLL1-KO__ab833 GSE101646.PHIP.HCT-116_MLL1-KO__ab833 270 bp overlap

POU1F1 1 dataset

Motif DE_36h DE_36h-POU1F1_MA0784.3 14 bp overlap

POU2F2 1 dataset

Motif DE_36h DE_36h-POU2F2_MA0507.3 13 bp overlap

POU3F2 1 dataset

Motif DE_36h DE_36h-POU3F2_MA0787.1 12 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 380 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 442 bp overlap

PRDM4 2 datasets

ChIP HEK293 ENCFF069PHD 385 bp overlap

ChIP HEK293 ENCSR443MVV.PRDM4.HEK293 344 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_36h DE_36h-Pou5f1Sox2_MA0142.1 15 bp overlap

Prdm4 1 dataset

Motif DE_36h DE_36h-Prdm4_MA1647.3 11 bp overlap

RREB1 2 datasets

Motif DE_24h DE_24h-RREB1_MA0073.2 19 bp overlap

Motif DE_36h DE_36h-RREB1_MA0073.2 19 bp overlap

RXRB 1 dataset

Motif DE_36h DE_36h-RXRB_MA0855.1 14 bp overlap

RXRG 1 dataset

Motif DE_36h DE_36h-RXRG_MA0856.1 14 bp overlap

Rxra 1 dataset

Motif DE_36h DE_36h-Rxra_MA0512.2 14 bp overlap

SMAD2 2 datasets

ChIP endoderm GSE29422.SMAD2.endoderm 223 bp overlap

ChIP hESC_YAP-_activinA_15h GSE99202.SMAD2.hESC_YAP-_activinA_15h 496 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 536 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 536 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 536 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 517 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 536 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 536 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 536 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 482 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 259 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 262 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 442 bp overlap

SOX8 1 dataset

ChIP RH4 GSE116344.SOX8.RH4 241 bp overlap

SP4 1 dataset

Motif DE_36h DE_36h-SP4_MA0685.2 9 bp overlap

SP5 2 datasets

Motif DE_36h DE_36h-SP5_MA1965.2 6 bp overlap

STAT1::STAT2 1 dataset

Motif DE_36h DE_36h-STAT1STAT2_MA0517.2 13 bp overlap

Stat4 1 dataset

Motif DE_36h DE_36h-Stat4_MA0518.2 10 bp overlap

Stat6 1 dataset

Motif DE_36h DE_36h-Stat6_MA0520.2 10 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

TBX5 2 datasets

Motif DE_24h DE_24h-TBX5_MA0807.1 8 bp overlap

Motif DE_36h DE_36h-TBX5_MA0807.1 8 bp overlap

TRPS1 1 dataset

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

Tbx6 1 dataset

Motif DE_36h DE_36h-Tbx6_MA1567.3 9 bp overlap

Tcf12 2 datasets

Motif DE_24h DE_24h-Tcf12_MA0521.3 6 bp overlap

Motif DE_36h DE_36h-Tcf12_MA0521.3 6 bp overlap

Twist2 2 datasets

Motif DE_24h DE_24h-Twist2_MA0633.3 6 bp overlap

Motif DE_36h DE_36h-Twist2_MA0633.3 6 bp overlap

ZBTB6 1 dataset

Motif DE_36h DE_36h-ZBTB6_MA1581.2 9 bp overlap

ZIM3 3 datasets

Motif DE_24h DE_24h-ZIM3_MA1709.2 11 bp overlap

Motif DE_36h DE_36h-ZIM3_MA1709.2 11 bp overlap

ChIP HEK293 GSE76494.ZIM3.HEK293 273 bp overlap

ZNF135 1 dataset

Motif DE_36h DE_36h-ZNF135_MA1587.1 14 bp overlap

ZNF157 2 datasets

Motif DE_24h DE_24h-ZNF157_MA2331.1 21 bp overlap

Motif DE_36h DE_36h-ZNF157_MA2331.1 21 bp overlap

ZNF263 1 dataset

Motif DE_36h DE_36h-ZNF263_MA0528.3 7 bp overlap

ZNF282 2 datasets

Motif DE_24h DE_24h-ZNF282_MA1154.2 15 bp overlap

Motif DE_36h DE_36h-ZNF282_MA1154.2 15 bp overlap

ZNF354C 2 datasets

Motif DE_24h DE_24h-ZNF354C_MA0130.1 6 bp overlap

Motif DE_36h DE_36h-ZNF354C_MA0130.1 6 bp overlap

ZNF549 2 datasets

Motif DE_24h DE_24h-ZNF549_MA1728.2 8 bp overlap

Motif DE_36h DE_36h-ZNF549_MA1728.2 8 bp overlap

ZNF701 1 dataset

Motif DE_36h DE_36h-ZNF701_MA1987.2 17 bp overlap

Zic2 2 datasets

Motif DE_24h DE_24h-Zic2_MA1629.2 9 bp overlap

Motif DE_36h DE_36h-Zic2_MA1629.2 9 bp overlap