Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TOX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:43,657,233–43,658,086 | 257.3 kb | Distal (>10kb) Multiome | 995 | |
| chr20:43,666,536–43,667,856 | 247.8 kb | Distal (>10kb) Multiome | 852 | |
| chr20:43,732,772–43,733,261 | 181.8 kb | Distal (>10kb) Multiome | 21 | |
| chr20:43,914,353–43,915,171 | 56 bp | At TSS Multiome | 285 | |
| chr20:43,915,599–43,916,049 | 748 bp | At TSS | 174 | |
| chr20:43,977,883–43,978,419 | 63.3 kb | Distal (>10kb) Multiome | 84 | |
| chr20:44,031,571–44,032,501 | 117.2 kb | Distal (>10kb) Multiome | 106 | |
| chr20:44,210,101–44,211,557 | 296.1 kb | Distal (>10kb) Multiome | 1054 |
Genomic view of the TOX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.