chr18:3,346,756–3,347,972

chr18 : 3,346,756 – 3,347,972

1,216 bp 44 TFs 6 linked genes

This 1.2 kb open chromatin element is linked to 6 target genes and is bound by 44 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
MYL12B		85.2 kb	Distal	Multiome
MYL12A		99.5 kb	Distal	Multiome
TGIF1		100.3 kb	Distal	Multiome
MYOM1		217.7 kb	Distal	Multiome
DLGAP1-AS1		246.8 kb	Distal	Multiome
DLGAP1-AS2		246.8 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

44 transcription factors

CTCF 14 datasets

ChIP GM23338 ENCFF772DML 201 bp overlap

ChIP HAP1_clone21_CTCF-CRISPR GSE152721.CTCF.HAP1_clone21_CTCF-CRISPR 493 bp overlap

ChIP HAP1_clone21_CTCF-TSS-CRISPR_1 GSE152721.CTCF.HAP1_clone21_CTCF-TSS-CRISPR_1 278 bp overlap

ChIP HAP1_clone21_CTCF-TSS-CRISPR_2 GSE152721.CTCF.HAP1_clone21_CTCF-TSS-CRISPR_2 266 bp overlap

ChIP HAP1_clone21_TSS-CRISPR GSE152721.CTCF.HAP1_clone21_TSS-CRISPR 199 bp overlap

ChIP HAP1_clone25 GSE152721.CTCF.HAP1_clone25 190 bp overlap

ChIP HEK293 ENCSR617IFZ.CTCF.HEK293 213 bp overlap

ChIP MCF-7 ENCFF414SZG 191 bp overlap

ChIP MCF-7 GSE137216.CTCF.MCF-7 214 bp overlap

ChIP MCF-7 GSE70764.CTCF.MCF-7 102 bp overlap

ChIP ZR751 ERP000783.CTCF.ZR751 139 bp overlap

ChIP keratinocyte ENCFF046PBT 185 bp overlap

ChIP keratinocyte ENCFF291YDC 185 bp overlap

ChIP keratinocyte ENCSR000DNC.CTCF.keratinocyte 106 bp overlap

EGR1 5 datasets

ChIP K-562 ENCSR024CNP.EGR1.K-562 152 bp overlap

ChIP K-562 ENCSR211LTF.EGR1.K-562 85 bp overlap

ChIP K562 ENCFF895KGN 79 bp overlap

ChIP fibroblast_DOX-24h GSE134924.EGR1.fibroblast_DOX-24h 98 bp overlap

ChIP fibroblast_DOX-CLOB-24h GSE134924.EGR1.fibroblast_DOX-CLOB-24h 60 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 337 bp overlap

ChIP hESC GSE26097.EOMES.hESC 200 bp overlap

ERF::FOXI1 1 dataset

Motif DE_60h DE_60h-ERFFOXI1_MA1935.2 10 bp overlap

ERF::FOXO1 1 dataset

Motif DE_60h DE_60h-ERFFOXO1_MA1936.2 12 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_60h DE_60h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::FOXI1 1 dataset

Motif DE_60h DE_60h-ETV5FOXI1_MA1946.2 12 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_60h DE_60h-ETV5FOXO1_MA1947.2 10 bp overlap

ChIP neural progenitor cell ENCFF018MKA 496 bp overlap

EZH2_phosphoT487 1 dataset

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 388 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_60h DE_60h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 964 bp overlap

ChIP DE DE-FOXA2-2 900 bp overlap

FOXJ2::ELF1 1 dataset

Motif DE_60h DE_60h-FOXJ2ELF1_MA1952.2 11 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_60h DE_60h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_60h DE_60h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_60h DE_60h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 902 bp overlap

ChIP DE DE-GATA4-2 1126 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 931 bp overlap

ChIP DE DE-GATA6-2 1092 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 536 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 310 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 394 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 653 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 401 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 653 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 481 bp overlap

GRHL2 1 dataset

Motif DE_60h DE_60h-GRHL2_MA1105.3 8 bp overlap

HMBOX1 1 dataset

ChIP K562 ENCFF055GAZ 180 bp overlap

ChIP K-562 ENCSR005NMT.ID3.K-562 170 bp overlap

ChIP P493-6_MST-312 GSE77061.MYC.P493-6_MST-312 136 bp overlap

NEUROD1 2 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 766 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 661 bp overlap

Motif DE_60h DE_60h-OSR2_MA1646.2 8 bp overlap

PLAGL2 1 dataset

Motif DE_60h DE_60h-PLAGL2_MA1548.2 8 bp overlap

POU4F2 2 datasets

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 126 bp overlap

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 126 bp overlap

PRDM1 1 dataset

ChIP fetal_testis GSE100639.PRDM1.fetal_testis 195 bp overlap

RAD21 3 datasets

ChIP HAP1 GSE152721.RAD21.HAP1 526 bp overlap

ChIP K-562_RF2-insertion GSE140868.RAD21.K-562_RF2-insertion 165 bp overlap

ChIP MCF-7 GSE137216.RAD21.MCF-7 186 bp overlap

SIN3A 1 dataset

ChIP HUVEC-C GSE103245.SIN3A.HUVEC-C 162 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 515 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 258 bp overlap

SMAD2_3 3 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 264 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 761 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 366 bp overlap

SMARCA4 1 dataset

ChIP NSC GSE125033.SMARCA4.NSC 278 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 328 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 646 bp overlap

ChIP HNSC GSE69479.SOX2.HNSC 195 bp overlap

SOX21 1 dataset

ChIP neuroepithelilal-cells GSE110505.SOX21.neuroepithelilal-cells 403 bp overlap

STAG1 1 dataset

ChIP Hep-G2 ENCSR167MTG.STAG1.Hep-G2 159 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 182 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 407 bp overlap

TEAD1 1 dataset

Motif DE_60h DE_60h-TEAD1_MA0090.4 9 bp overlap

TEAD4 1 dataset

Motif DE_60h DE_60h-TEAD4_MA0809.3 8 bp overlap

ChIP keratinocyte_D0 GSE59824.TP63.keratinocyte_D0 52 bp overlap

ZNF341 1 dataset

Motif DE_60h DE_60h-ZNF341_MA1655.2 8 bp overlap

ZNF677 1 dataset

Motif DE_60h DE_60h-ZNF677_MA2101.1 12 bp overlap

Zfp335 1 dataset

Motif DE_60h DE_60h-Zfp335_MA2002.2 7 bp overlap