This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for MYL12A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYL12A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYL12A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:2,894,188–2,895,797 | 352.8 kb | Distal (>10kb) Multiome HiCAR | 326 | |
| chr18:3,012,394–3,013,832 | 234.5 kb | Distal (>10kb) Multiome | 816 | |
| chr18:3,245,709–3,246,515 | 1.7 kb | Proximal (<10kb) Multiome | 627 | |
| chr18:3,246,619–3,248,313 | 245 bp | At TSS Multiome | 1018 | |
| chr18:3,261,342–3,262,799 | 14.2 kb | Distal (>10kb) Multiome | 929 | |
| chr18:3,296,788–3,297,724 | 49.6 kb | Distal (>10kb) Multiome | 828 | |
| chr18:3,346,756–3,347,972 | 99.5 kb | Distal (>10kb) Multiome | 44 | |
| chr18:3,447,486–3,448,604 | 200.4 kb | Distal (>10kb) Multiome | 938 | |
| chr18:3,448,748–3,450,993 | 202.2 kb | Distal (>10kb) Multiome | 909 | |
| chr18:3,498,885–3,499,424 | 251.5 kb | Distal (>10kb) Multiome | 144 |
Genomic view of the MYL12A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.