chr18 : 313,811 – 314,749

938 bp 63 TFs 4 linked genes

This 938 bp open chromatin element is linked to 4 target genes and is bound by 63 transcription factors.

Linked Genes

4 genes

Gene	Dist. to TSS	Distance	Link type
THOC1	46.1 kb	Distal	Multiome
USP14	155.6 kb	Distal	Multiome
COLEC12	186.6 kb	Distal	Multiome
CLUL1	282.9 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

63 transcription factors

ARID2 1 dataset

ChIP Aska-SS GSE108025.ARID2.Aska-SS 833 bp overlap

CBX2 2 datasets

ChIP K-562 ENCSR000ATU.CBX2.K-562 497 bp overlap

ChIP K-562 ENCSR000ATU.CBX2.K-562 206 bp overlap

CBX8 1 dataset

ChIP K-562 ENCSR000ATW.CBX8.K-562 314 bp overlap

CHD7 2 datasets

ChIP hiPSC_AF22_abD3F5 GSE108506.CHD7.hiPSC_AF22_abD3F5 198 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 433 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 233 bp overlap

ERF::FOXI1 2 datasets

Motif DE_48h DE_48h-ERFFOXI1_MA1935.2 10 bp overlap

Motif DE_60h DE_60h-ERFFOXI1_MA1935.2 10 bp overlap

ETV1 1 dataset

ChIP A-375 GSE80443.ETV1.A-375 296 bp overlap

ETV2 2 datasets

Motif DE_48h DE_48h-ETV2_MA0762.2 9 bp overlap

Motif DE_60h DE_60h-ETV2_MA0762.2 9 bp overlap

ETV2::FOXI1 3 datasets

Motif DE_48h DE_48h-ETV2FOXI1_MA1942.2 11 bp overlap

Motif DE_60h DE_60h-ETV2FOXI1_MA1942.2 11 bp overlap

Motif DE_72h DE_72h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::FOXO1 2 datasets

Motif DE_48h DE_48h-ETV5FOXO1_MA1947.2 10 bp overlap

Motif DE_60h DE_60h-ETV5FOXO1_MA1947.2 10 bp overlap

EWSR1-FLI1 1 dataset

Motif DE_72h DE_72h-EWSR1-FLI1_MA0149.1 18 bp overlap

FLI1::FOXI1 2 datasets

Motif DE_48h DE_48h-FLI1FOXI1_MA1950.2 11 bp overlap

Motif DE_60h DE_60h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 710 bp overlap

ChIP DE DE-FOXA2-2 550 bp overlap

FOXO1::ELF1 2 datasets

Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap

Motif DE_60h DE_60h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 2 datasets

Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap

Motif DE_60h DE_60h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::FLI1 2 datasets

Motif DE_48h DE_48h-FOXO1FLI1_MA1956.2 13 bp overlap

Motif DE_60h DE_60h-FOXO1FLI1_MA1956.2 13 bp overlap

GABPA 1 dataset

ChIP VCaP_R1881 GSE49091.GABPA.VCaP_R1881 132 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 587 bp overlap

ChIP DE DE-GATA4-2 653 bp overlap

GATA6 4 datasets

ChIP DE DE-GATA6-1 623 bp overlap

ChIP DE DE-GATA6-2 694 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 664 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 438 bp overlap

GLI3 1 dataset

Motif DE_48h DE_48h-GLI3_MA1491.3 15 bp overlap

GLIS1 1 dataset

Motif DE_48h DE_48h-GLIS1_MA0735.2 15 bp overlap

Gli1 1 dataset

Motif DE_48h DE_48h-Gli1_MA1990.2 10 bp overlap

HNF4A 3 datasets

Motif DE_48h DE_48h-HNF4A_MA0114.5 9 bp overlap

Motif DE_60h DE_60h-HNF4A_MA0114.5 9 bp overlap

Motif DE_72h DE_72h-HNF4A_MA0114.5 9 bp overlap

HNF4G 3 datasets

Motif DE_48h DE_48h-HNF4G_MA0484.3 9 bp overlap

Motif DE_60h DE_60h-HNF4G_MA0484.3 9 bp overlap

Motif DE_72h DE_72h-HNF4G_MA0484.3 9 bp overlap

IKZF1 2 datasets

Motif DE_48h DE_48h-IKZF1_MA1508.2 8 bp overlap

Motif DE_60h DE_60h-IKZF1_MA1508.2 8 bp overlap

IKZF2 1 dataset

Motif DE_72h DE_72h-IKZF2_MA2326.1 6 bp overlap

MEIS1 3 datasets

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MEIS3 2 datasets

Motif DE_48h DE_48h-MEIS3_MA0775.2 7 bp overlap

Motif DE_72h DE_72h-MEIS3_MA0775.2 7 bp overlap

RBPJ 1 dataset

Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap

RXRA::VDR 1 dataset

Motif DE_72h DE_72h-RXRAVDR_MA0074.1 15 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 715 bp overlap

ChIP HUVEC-C_TGFB1 GSE134556.SMAD2-3.HUVEC-C_TGFB1 297 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 546 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 604 bp overlap

SMARCA4 4 datasets

ChIP 501-mel_SHCTR GSE61965.SMARCA4.501-mel_SHCTR 355 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-T910M 298 bp overlap

ChIP NSC GSE125033.SMARCA4.NSC 156 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 269 bp overlap

SOX10 4 datasets

ChIP 501-mel GSE61965.SOX10.501-mel 282 bp overlap

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap

SOX13 3 datasets

Motif DE_72h DE_72h-SOX13_MA1120.2 7 bp overlap

ChIP Hep-G2 ENCSR445ACU.SOX13.Hep-G2 175 bp overlap

ChIP HepG2 ENCFF062VSQ 357 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 450 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 584 bp overlap

SOX2 2 datasets

Motif DE_72h DE_72h-SOX2_MA0143.5 7 bp overlap

ChIP hiPSC_KDP53_INHI GSE67282.SOX2.hiPSC_KDP53_INHI 225 bp overlap

SOX21 3 datasets

Motif DE_48h DE_48h-SOX21_MA0866.1 15 bp overlap

Motif DE_60h DE_60h-SOX21_MA0866.1 15 bp overlap

Motif DE_72h DE_72h-SOX21_MA0866.1 15 bp overlap

SOX5 1 dataset

ChIP HepG2 ENCFF470KZD 405 bp overlap

SPIB 1 dataset

Motif DE_72h DE_72h-SPIB_MA0081.3 13 bp overlap

SS18 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.SS18.BIN-67_lentivirus-SMARCA4-T910M 304 bp overlap

Sox1 3 datasets

Motif DE_48h DE_48h-Sox1_MA0870.1 15 bp overlap

Motif DE_60h DE_60h-Sox1_MA0870.1 15 bp overlap

Motif DE_72h DE_72h-Sox1_MA0870.1 15 bp overlap

Sox11 3 datasets

Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap

Motif DE_60h DE_60h-Sox11_MA0869.3 8 bp overlap

Motif DE_72h DE_72h-Sox11_MA0869.3 8 bp overlap

Sox17 1 dataset

Motif DE_72h DE_72h-Sox17_MA0078.3 10 bp overlap

Sox3 1 dataset

Motif DE_72h DE_72h-Sox3_MA0514.3 7 bp overlap

Sox5 1 dataset

Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap

Sox6 1 dataset

Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap

Sox7 1 dataset

Motif DE_72h DE_72h-Sox7_MA2095.1 10 bp overlap

TCF7L1 1 dataset

Motif DE_48h DE_48h-TCF7L1_MA1421.1 12 bp overlap

ZIM3 2 datasets

Motif DE_48h DE_48h-ZIM3_MA1709.2 11 bp overlap

Motif DE_60h DE_60h-ZIM3_MA1709.2 11 bp overlap

ZNF136 1 dataset

Motif DE_48h DE_48h-ZNF136_MA1588.1 15 bp overlap

ZNF19 1 dataset

ChIP HEK293T GSE78099.ZNF19.HEK293T 294 bp overlap

ZNF213 3 datasets

Motif DE_48h DE_48h-ZNF213_MA2121.1 12 bp overlap

Motif DE_60h DE_60h-ZNF213_MA2121.1 12 bp overlap

Motif DE_72h DE_72h-ZNF213_MA2121.1 12 bp overlap

ZNF416 3 datasets

Motif DE_48h DE_48h-ZNF416_MA1979.2 10 bp overlap

Motif DE_60h DE_60h-ZNF416_MA1979.2 10 bp overlap

Motif DE_72h DE_72h-ZNF416_MA1979.2 10 bp overlap

ZNF418 1 dataset

Motif DE_48h DE_48h-ZNF418_MA1980.1 15 bp overlap

ZNF524 1 dataset

Motif DE_72h DE_72h-ZNF524_MA2096.1 9 bp overlap

ZNF582 2 datasets

Motif DE_48h DE_48h-ZNF582_MA1983.2 19 bp overlap

Motif DE_60h DE_60h-ZNF582_MA1983.2 19 bp overlap

ZNF660 1 dataset

ChIP HEK293 ENCSR283DOU.ZNF660.HEK293 165 bp overlap

ZNF675 3 datasets

Motif DE_48h DE_48h-ZNF675_MA1714.2 19 bp overlap

Motif DE_60h DE_60h-ZNF675_MA1714.2 19 bp overlap

ZNF677 5 datasets

Motif DE_48h DE_48h-ZNF677_MA2101.1 12 bp overlap

Motif DE_60h DE_60h-ZNF677_MA2101.1 12 bp overlap

Motif DE_72h DE_72h-ZNF677_MA2101.1 12 bp overlap

ZNF680 2 datasets

Motif DE_48h DE_48h-ZNF680_MA1729.2 11 bp overlap

Motif DE_60h DE_60h-ZNF680_MA1729.2 11 bp overlap

ZNF768 1 dataset

Motif DE_72h DE_72h-ZNF768_MA1731.2 9 bp overlap