Predicted to enable misfolded protein binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CLUL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLUL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLUL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:267,462–268,836 | 329.0 kb | Distal (>10kb) Multiome HiCAR | 1007 | |
| chr18:313,811–314,749 | 282.9 kb | Distal (>10kb) Multiome HiCAR | 63 | |
| chr18:499,984–501,449 | 96.3 kb | Distal (>10kb) Multiome | 306 | |
| chr18:516,064–516,762 | 80.7 kb | Distal (>10kb) Multiome | 96 | |
| chr18:596,306–596,847 | 174 bp | At TSS | 245 | |
| chr18:596,942–597,511 | 15 bp | At TSS Multiome | 522 | |
| chr18:657,152–658,975 | 61.4 kb | Distal (>10kb) Multiome | 968 | |
| chr18:685,991–687,114 | 89.5 kb | Distal (>10kb) Multiome | 127 | |
| chr18:712,215–713,458 | 115.7 kb | Distal (>10kb) Multiome | 797 | |
| chr18:811,520–813,366 | 215.4 kb | Distal (>10kb) Multiome | 893 |
Genomic view of the CLUL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.