Predicted to enable DNA binding activity and RNA binding activity. Involved in mRNA export from nucleus. Located in chromosome, telomeric region; cytoplasm; and nuclear speck. Part of THO complex part of transcription export complex. Implicated in autosomal dominant nonsyndromic deafness 86. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THOC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THOC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THOC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:158,024–159,212 | 109.6 kb | Distal (>10kb) Multiome | 1025 | |
| chr18:267,462–268,836 | 26 bp | At TSS Multiome | 1007 | |
| chr18:272,494–273,102 | 4.5 kb | Proximal (<10kb) | 18 | |
| chr18:313,811–314,749 | 46.1 kb | Distal (>10kb) Multiome | 63 | |
| chr18:499,984–501,449 | 232.7 kb | Distal (>10kb) Multiome | 306 | |
| chr18:516,064–516,762 | 248.3 kb | Distal (>10kb) Multiome | 96 | |
| chr18:596,942–597,511 | 329.0 kb | Distal (>10kb) Multiome HiCAR | 522 | |
| chr18:657,152–658,975 | 390.4 kb | Distal (>10kb) Multiome HiCAR | 968 |
Genomic view of the THOC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.