chr1 : 22,442,329 – 22,443,072
743 bp 41 TFs 3 linked genes
This 743 bp open chromatin element is linked to ZBTB40, EPHB2, and WNT4 and is bound by 41 transcription factors.
Linked Genes
3 genes
Distance
Link type
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
ZBTB40 8.8 kb Proximal Proximity
EPHB2 268.2 kb Distal Multiome
WNT4 299.5 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr1:22,437,329 – 22,448,072
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
41 transcription factors
Source
Cell type
AR 1 dataset
ChIP MCF-7 ERP001226.AR.MCF-7 275 bp overlap
ARID1B 1 dataset
ChIP K562 ENCFF938UXQ 541 bp overlap
ARID2 1 dataset
ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.ARID2.MCF-7_parental_4-hydroxytamoxifen 273 bp overlap
ASH2L 1 dataset
ChIP WA01 ENCSR850KIP.ASH2L.WA01 408 bp overlap
CBFA2T2 1 dataset
ChIP K562 ENCFF963TXY 181 bp overlap
CBFA2T3 2 datasets
ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 285 bp overlap
ChIP K562 ENCFF673OEZ 272 bp overlap
CTCF 4 datasets
ChIP GM23338 ENCFF531QOI 194 bp overlap
ChIP GM23338 ENCFF772DML 201 bp overlap
ChIP H1 ENCFF764RHO 229 bp overlap
ChIP endodermal cell ENCFF471YCZ 362 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 348 bp overlap
ESR1 83 datasets
ChIP MCF-7 ENCFF004AKH 361 bp overlap
ChIP MCF-7 GSE148277.ESR1.MCF-7 288 bp overlap
ChIP MCF-7 GSE76893.ESR1.MCF-7 325 bp overlap
ChIP MCF-7 GSE68355.ESR1.MCF-7 267 bp overlap
ChIP MCF-7 GSE48930.ESR1.MCF-7 225 bp overlap
ChIP MCF-7 GSE41561.ESR1.MCF-7 275 bp overlap
ChIP MCF-7 GSE103023.ESR1.MCF-7 267 bp overlap
ChIP MCF-7 ERP000209.ESR1.MCF-7 170 bp overlap
ChIP MCF-7-Luc-Y537S_E2 GSE78284.ESR1.MCF-7-Luc-Y537S_E2 186 bp overlap
ChIP MCF-7-Luc_E2 GSE78284.ESR1.MCF-7-Luc_E2 343 bp overlap
ChIP MCF-7_ARID1A-KO GSE123284.ESR1.MCF-7_ARID1A-KO 245 bp overlap
ChIP MCF-7_ARID1A-KO_4-OHT GSE123284.ESR1.MCF-7_ARID1A-KO_4-OHT 343 bp overlap
ChIP MCF-7_ARID1A-KO_4-OHT_clone14 GSE123284.ESR1.MCF-7_ARID1A-KO_4-OHT_clone14 335 bp overlap
ChIP MCF-7_ARID1A-KO_clone14 GSE123284.ESR1.MCF-7_ARID1A-KO_clone14 291 bp overlap
ChIP MCF-7_AZD2014 GSE103023.ESR1.MCF-7_AZD2014 235 bp overlap
ChIP MCF-7_D538G GSE148277.ESR1.MCF-7_D538G 275 bp overlap
ChIP MCF-7_D538G_DMSO GSE148277.ESR1.MCF-7_D538G_DMSO 257 bp overlap
ChIP MCF-7_DMSO GSE125594.ESR1.MCF-7_DMSO 286 bp overlap
ChIP MCF-7_E2 ERP000209.ESR1.MCF-7_E2 294 bp overlap
ChIP MCF-7_E2 ERP000380.ESR1.MCF-7_E2 206 bp overlap
ChIP MCF-7_E2 ERP000901.ESR1.MCF-7_E2 196 bp overlap
ChIP MCF-7_E2 GSE60270.ESR1.MCF-7_E2 162 bp overlap
ChIP MCF-7_E2 GSE55921.ESR1.MCF-7_E2 164 bp overlap
ChIP MCF-7_E2 GSE108883.ESR1.MCF-7_E2 236 bp overlap
ChIP MCF-7_E2-10min-ERalpha GSE94023.ESR1.MCF-7_E2-10min-ERalpha 257 bp overlap
ChIP MCF-7_E2-20min-ERalpha GSE94023.ESR1.MCF-7_E2-20min-ERalpha 291 bp overlap
ChIP MCF-7_E2-40min-ERalpha GSE94023.ESR1.MCF-7_E2-40min-ERalpha 288 bp overlap
ChIP MCF-7_E2-5min-ERalpha GSE94023.ESR1.MCF-7_E2-5min-ERalpha 249 bp overlap
ChIP MCF-7_E2-80min-ERalpha GSE94023.ESR1.MCF-7_E2-80min-ERalpha 247 bp overlap
ChIP MCF-7_E2_30min GSE108883.ESR1.MCF-7_E2_30min 165 bp overlap
ChIP MCF-7_E2_45min GSE109820.ESR1.MCF-7_E2_45min 354 bp overlap
ChIP MCF-7_E2_90min GSE109820.ESR1.MCF-7_E2_90min 396 bp overlap
ChIP MCF-7_ER_t50 GSE119057.ESR1.MCF-7_ER_t50 167 bp overlap
ChIP MCF-7_Fulvestrant_HC11 GSE102882.ESR1.MCF-7_Fulvestrant_HC11 228 bp overlap
ChIP MCF-7_GLYC ERP002305.ESR1.MCF-7_GLYC 226 bp overlap
ChIP MCF-7_HC11 GSE102882.ESR1.MCF-7_HC11 298 bp overlap
ChIP MCF-7_PROG GSE68355.ESR1.MCF-7_PROG 384 bp overlap
ChIP MCF-7_R5020 GSE68355.ESR1.MCF-7_R5020 381 bp overlap
ChIP MCF-7_RAD001 GSE103023.ESR1.MCF-7_RAD001 273 bp overlap
ChIP MCF-7_SHCRT_E2 ERP000380.ESR1.MCF-7_SHCRT_E2 171 bp overlap
ChIP MCF-7_SHFOXA1_E2 ERP000380.ESR1.MCF-7_SHFOXA1_E2 229 bp overlap
ChIP MCF-7_SICTR_E2 GSE40129.ESR1.MCF-7_SICTR_E2 214 bp overlap
ChIP MCF-7_SIGATA_E2 GSE40129.ESR1.MCF-7_SIGATA_E2 186 bp overlap
ChIP MCF-7_TAM ERP000380.ESR1.MCF-7_TAM 195 bp overlap
ChIP MCF-7_TamR GSE128445.ESR1.MCF-7_TamR 220 bp overlap
ChIP MCF-7_estradiol-DHT_4h GSE99626.ESR1.MCF-7_estradiol-DHT_4h 242 bp overlap
ChIP MCF-7_estradiol-Dex_4h GSE99626.ESR1.MCF-7_estradiol-Dex_4h 254 bp overlap
ChIP MCF-7_estradiol-Dex_75min GSE99626.ESR1.MCF-7_estradiol-Dex_75min 163 bp overlap
ChIP MCF-7_estradiol-aldosterone_4h GSE99626.ESR1.MCF-7_estradiol-aldosterone_4h 198 bp overlap
ChIP MCF-7_estradiol-progesterone_4h GSE99626.ESR1.MCF-7_estradiol-progesterone_4h 207 bp overlap
ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 252 bp overlap
ChIP MCF-7_jc5849 GSE126004.ESR1.MCF-7_jc5849 383 bp overlap
ChIP MCF-7_jc5850 GSE126004.ESR1.MCF-7_jc5850 398 bp overlap
ChIP MCF-7_jc5852 GSE126004.ESR1.MCF-7_jc5852 284 bp overlap
ChIP MCF-7_jc5853 GSE126004.ESR1.MCF-7_jc5853 358 bp overlap
ChIP MCF-7_jc5854 GSE126004.ESR1.MCF-7_jc5854 248 bp overlap
ChIP MCF-7_jc5855 GSE126004.ESR1.MCF-7_jc5855 278 bp overlap
ChIP MCF-7_jc5856 GSE126004.ESR1.MCF-7_jc5856 255 bp overlap
ChIP MCF-7_parental GSE123284.ESR1.MCF-7_parental 227 bp overlap
ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.ESR1.MCF-7_parental_4-hydroxytamoxifen 330 bp overlap
ChIP MCF-7_shFbxo GSE119702.ESR1.MCF-7_shFbxo 166 bp overlap
ChIP MCF-7_shFbxo_E2 GSE119702.ESR1.MCF-7_shFbxo_E2 166 bp overlap
ChIP MDA-MB-134-VI_E2 GSE109103.ESR1.MDA-MB-134-VI_E2 228 bp overlap
ChIP T-47D GSE148277.ESR1.T-47D 660 bp overlap
ChIP T-47D ENCSR000BJS.ESR1.T-47D 320 bp overlap
ChIP T-47D ENCSR000BKN.ESR1.T-47D 327 bp overlap
ChIP T-47D ENCSR000BQD.ESR1.T-47D 172 bp overlap
ChIP T-47D GSE74033.ESR1.T-47D 195 bp overlap
ChIP T-47D GSE84593.ESR1.T-47D 171 bp overlap
ChIP T-47D_CR3flp GSE99479.ESR1.T-47D_CR3flp 146 bp overlap
ChIP T-47D_CR3flp GSE99479.ESR1.T-47D_CR3flp 422 bp overlap
ChIP T-47D_D538G_E2 GSE148277.ESR1.T-47D_D538G_E2 496 bp overlap
ChIP T-47D_JC4726 GSE126004.ESR1.T-47D_JC4726 188 bp overlap
ChIP T-47D_JC4730 GSE126004.ESR1.T-47D_JC4730 308 bp overlap
ChIP T-47D_JC4732 GSE126004.ESR1.T-47D_JC4732 323 bp overlap
ChIP T-47D_JC4733 GSE126004.ESR1.T-47D_JC4733 227 bp overlap
ChIP T-47D_Y537S GSE148277.ESR1.T-47D_Y537S 291 bp overlap
ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 540 bp overlap
ChIP T-47D_flp-ctrl GSE99479.ESR1.T-47D_flp-ctrl 416 bp overlap
ChIP T-47D_siCont-IL6 GSE126004.ESR1.T-47D_siCont-IL6 366 bp overlap
ChIP T-47D_siCont-Veh GSE126004.ESR1.T-47D_siCont-Veh 330 bp overlap
ChIP T-47D_siFOXA1-IL6 GSE126004.ESR1.T-47D_siFOXA1-IL6 312 bp overlap
ChIP T-47D_siFOXA1-Veh GSE126004.ESR1.T-47D_siFOXA1-Veh 445 bp overlap
ESR1_Y537S 4 datasets
ChIP MCF-7_E2 GSE94493.ESR1_Y537S.MCF-7_E2 197 bp overlap
ChIP T-47D_E2 GSE94493.ESR1_Y537S.T-47D_E2 267 bp overlap
ChIP T-47D_dox GSE94493.ESR1_Y537S.T-47D_dox 220 bp overlap
ChIP T-47D_dox_E2 GSE94493.ESR1_Y537S.T-47D_dox_E2 204 bp overlap
ESR1_pS118 1 dataset
ChIP MCF-7_E2_sc GSE117569.ESR1_pS118.MCF-7_E2_sc 390 bp overlap
ESRRA 3 datasets
ChIP SK-BR-3 GSE81651.ESRRA.SK-BR-3 123 bp overlap
ChIP SK-BR-3_EGF GSE81651.ESRRA.SK-BR-3_EGF 116 bp overlap
ChIP SK-BR-3_HRG GSE81651.ESRRA.SK-BR-3_HRG 127 bp overlap
ESRRG 2 datasets
ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 113 bp overlap
ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 280 bp overlap
FOXA1 1 dataset
ChIP T-47D_CR3flp GSE99479.FOXA1.T-47D_CR3flp 330 bp overlap
FOXA2 3 datasets
ChIP DE DE-FOXA2-1 668 bp overlap
ChIP DE DE-FOXA2-2 552 bp overlap
ChIP PANC-1_HNF1B-OE GSE119930.FOXA2.PANC-1_HNF1B-OE 311 bp overlap
GATA3 1 dataset
ChIP MCF-7 ENCFF437NQS 371 bp overlap
GATA3_Nter 1 dataset
ChIP T-47D_CR3flp GSE99479.GATA3_Nter.T-47D_CR3flp 240 bp overlap
GATA4 5 datasets
ChIP DE DE-GATA4-1 738 bp overlap
ChIP DE DE-GATA4-2 743 bp overlap
ChIP foregut GSE117136.GATA4.foregut 442 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 514 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 487 bp overlap
GATA6 13 datasets
ChIP DE DE-GATA6-1 743 bp overlap
ChIP DE DE-GATA6-2 743 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 557 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 579 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 714 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 725 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 650 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 541 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 541 bp overlap
ChIP foregut GSE117136.GATA6.foregut 361 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 492 bp overlap
ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 421 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 481 bp overlap
JUN 5 datasets
ChIP DE_D1 S08-DE-d1-JUN-exp1 404 bp overlap
ChIP DE_D1 S40-DE-d1-JUN-exp2 548 bp overlap
ChIP DE_D2 S02-DE-d2-JUN-exp1 605 bp overlap
ChIP DE_D2 S54-DE-d2-JUN-exp2 441 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 517 bp overlap
MED1 1 dataset
ChIP G296S_4 GSE85628.MED1.G296S_4 199 bp overlap
NANOG 1 dataset
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 385 bp overlap
NCOA2 1 dataset
ChIP MCF-7_E2 ERP000901.NCOA2.MCF-7_E2 172 bp overlap
NCOR1 1 dataset
ChIP K562 ENCFF788MPU 421 bp overlap
NR2F2 2 datasets
ChIP MCF-7 ENCFF329FZB 361 bp overlap
ChIP MCF-7 ENCSR000BUY.NR2F2.MCF-7 187 bp overlap
NR3C1 1 dataset
ChIP T47D-A1-2_Dex GSE112491.NR3C1.T47D-A1-2_Dex 55 bp overlap
NRIP1 2 datasets
ChIP MCF-7 ERP005838.NRIP1.MCF-7 153 bp overlap
ChIP MCF-7_E2 ERP005838.NRIP1.MCF-7_E2 229 bp overlap
POU5F1 2 datasets
ChIP DE_D1 DED1-OCT4_Batch_II 323 bp overlap
ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 100 bp overlap
PPARG 2 datasets
ChIP Hep-G2 ENCSR130VQL.PPARG.Hep-G2 203 bp overlap
ChIP HepG2 ENCFF329FBJ 160 bp overlap
RAD21 1 dataset
ChIP H1 ENCFF698EWO 198 bp overlap
RARA 1 dataset
ChIP HepG2 ENCFF582XUA 357 bp overlap
RXR 1 dataset
ChIP pancreatic-progenitor_PP1 GSE104840.RXR.pancreatic-progenitor_PP1 230 bp overlap
RXRA 4 datasets
ChIP H1 ENCFF570NHK 201 bp overlap
ChIP Hep-G2 ENCSR000BHU.RXRA.Hep-G2 155 bp overlap
ChIP HepG2 ENCFF204YVO 297 bp overlap
ChIP WA01 ENCSR000BJW.RXRA.WA01 138 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 164 bp overlap
SMAD2-3 2 datasets
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 548 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 542 bp overlap
SMAD2_3 5 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 469 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 366 bp overlap
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 403 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 613 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 704 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 275 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 645 bp overlap
T 1 dataset
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 195 bp overlap
TAL1 2 datasets
ChIP K562 ENCFF620GMX 385 bp overlap
ChIP K562 ENCFF661CCK 277 bp overlap
TEAD3 1 dataset
ChIP HepG2 ENCFF054UUL 371 bp overlap
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