chr21 : 44,704,676 – 44,705,066
390 bp 40 TFs 1 linked gene
This 390 bp open chromatin element is linked to TSPEAR and is bound by 40 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
TSPEAR 6.5 kb Proximal Proximity
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr21:44,699,676 – 44,710,066
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
40 transcription factors
Source
Cell type
ARID1A 1 dataset
ChIP MCF-7_4-hydroxytamoxifen GSE123284.ARID1A.MCF-7_4-hydroxytamoxifen 138 bp overlap
ASH2L 1 dataset
ChIP WA01 ENCSR850KIP.ASH2L.WA01 390 bp overlap
BACH1 1 dataset
ChIP WA01 ENCSR000EBQ.BACH1.WA01 326 bp overlap
BCOR 3 datasets
ChIP WA01 GSE104690.BCOR.WA01 258 bp overlap
ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 291 bp overlap
ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 376 bp overlap
BRD1 1 dataset
ChIP HUES-64 GSE104059.BRD1.HUES-64 148 bp overlap
BRD4 1 dataset
ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 188 bp overlap
CHD7 1 dataset
ChIP WA01 ENCSR000AVA.CHD7.WA01 150 bp overlap
CREB1 2 datasets
ChIP Hep-G2 ENCSR112ALD.CREB1.Hep-G2 229 bp overlap
ChIP WA01 ENCSR000BSN.CREB1.WA01 125 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF364PUR 283 bp overlap
E2F1 2 datasets
ChIP MCF-7 ENCFF692OYJ 161 bp overlap
ChIP MCF-7 ENCSR000EWX.E2F1.MCF-7 80 bp overlap
EP300 1 dataset
ChIP osteoblast ENCSR000AUD.EP300.osteoblast 390 bp overlap
ESR1 16 datasets
ChIP Ishikawa_C2-14 GSE147141.ESR1.Ishikawa_C2-14 219 bp overlap
ChIP Ishikawa_E2_D538G_clone2 GSE132426.ESR1.Ishikawa_E2_D538G_clone2 250 bp overlap
ChIP Ishikawa_siNTC-72h GSE129803.ESR1.Ishikawa_siNTC-72h 71 bp overlap
ChIP Ishikawa_siNTC-96h GSE129803.ESR1.Ishikawa_siNTC-96h 88 bp overlap
ChIP MCF-7_D538G GSE148277.ESR1.MCF-7_D538G 172 bp overlap
ChIP MCF-7_E2 GSE117941.ESR1.MCF-7_E2 205 bp overlap
ChIP MCF-7_E2_30min GSE108883.ESR1.MCF-7_E2_30min 73 bp overlap
ChIP MCF-7_ICI_30min GSE108883.ESR1.MCF-7_ICI_30min 122 bp overlap
ChIP MCF-7_PaPE-1_OA GSE93510.ESR1.MCF-7_PaPE-1_OA 390 bp overlap
ChIP MCF-7_estradiol-DHT_4h GSE99626.ESR1.MCF-7_estradiol-DHT_4h 54 bp overlap
ChIP MCF-7_estradiol-progesterone_4h GSE99626.ESR1.MCF-7_estradiol-progesterone_4h 61 bp overlap
ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 81 bp overlap
ChIP MCF-7_jc5854 GSE126004.ESR1.MCF-7_jc5854 62 bp overlap
ChIP T-47D_D538G_E2 GSE148277.ESR1.T-47D_D538G_E2 211 bp overlap
ChIP T-47D_Y537S GSE148277.ESR1.T-47D_Y537S 56 bp overlap
ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 267 bp overlap
EZH2 15 datasets
ChIP GM23248 ENCSR131FFJ.EZH2.GM23248 291 bp overlap
ChIP HUVEC-C GSE109625.EZH2.HUVEC-C 336 bp overlap
ChIP HUVEC-C_VEGF_1h GSE109625.EZH2.HUVEC-C_VEGF_1h 139 bp overlap
ChIP SU-DHL-6 GSE134136.EZH2.SU-DHL-6 249 bp overlap
ChIP T98G GSE112240.EZH2.T98G 317 bp overlap
ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 390 bp overlap
ChIP dermal-fibroblast_Preneoplastic GSE126396.EZH2.dermal-fibroblast_Preneoplastic 307 bp overlap
ChIP dermal-fibroblast_Transformed GSE126396.EZH2.dermal-fibroblast_Transformed 340 bp overlap
ChIP dermal-fibroblast_Untransformed GSE126396.EZH2.dermal-fibroblast_Untransformed 337 bp overlap
ChIP endothelial cell of umbilical vein ENCFF539AKL 390 bp overlap
ChIP endothelial_umbilical-vein ENCSR000ATA.EZH2.endothelial_umbilical-vein 390 bp overlap
ChIP fibroblast_DERMAL ENCSR000ASE.EZH2.fibroblast_DERMAL 129 bp overlap
ChIP hepatocyte ENCSR384LYW.EZH2.hepatocyte 390 bp overlap
ChIP neural progenitor cell ENCFF472NFV 390 bp overlap
ChIP neural_progenitor ENCSR069DPL.EZH2.neural_progenitor 351 bp overlap
EZH2_phosphoT487 3 datasets
ChIP PC-9 ENCSR702GMW.EZH2_phosphoT487.PC-9 184 bp overlap
ChIP hepatocyte ENCSR341VYI.EZH2_phosphoT487.hepatocyte 266 bp overlap
ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 216 bp overlap
GABPA 1 dataset
ChIP WA01 ENCSR000BIW.GABPA.WA01 181 bp overlap
GATA6 2 datasets
ChIP DE_D1 S09-DE-d1-GATA6-exp1 226 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 156 bp overlap
GLIS3 1 dataset
ChIP H9_plus GSE109562.GLIS3.H9_plus 390 bp overlap
GRHL2 1 dataset
ChIP MCF-7-WS8_VEH GSE113092.GRHL2.MCF-7-WS8_VEH 60 bp overlap
HDAC2 3 datasets
ChIP H1 ENCFF353UJQ 381 bp overlap
ChIP WA01 ENCSR000AVB.HDAC2.WA01 281 bp overlap
ChIP WA01 ENCSR000BNR.HDAC2.WA01 174 bp overlap
HIF3A 1 dataset
ChIP Hep-3B2-1-7 GSE129491.HIF3A.Hep-3B2-1-7 225 bp overlap
HNRNPH1 1 dataset
ChIP Hep-G2 GSE120104.HNRNPH1.Hep-G2 124 bp overlap
HNRNPLL 2 datasets
ChIP Hep-G2 GSE120104.HNRNPLL.Hep-G2 215 bp overlap
ChIP Hep-G2 ENCSR804HMZ.HNRNPLL.Hep-G2 198 bp overlap
JARID2 3 datasets
ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 310 bp overlap
ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 55 bp overlap
ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 222 bp overlap
NANOG 3 datasets
ChIP HUES-8 GSE109524.NANOG.HUES-8 339 bp overlap
ChIP WA01 ENCSR000BMT.NANOG.WA01 166 bp overlap
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 306 bp overlap
NFKB1 2 datasets
ChIP HEK293T GSE129618.NFKB1.HEK293T 153 bp overlap
ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 218 bp overlap
PCGF1 1 dataset
ChIP WA01 GSE104690.PCGF1.WA01 390 bp overlap
POU5F1 3 datasets
ChIP DE_D1 DED1-OCT4_Batch_II 244 bp overlap
ChIP HUES-8 GSE109524.POU5F1.HUES-8 341 bp overlap
ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 183 bp overlap
RUNX1 1 dataset
ChIP Jurkat GSE85524.RUNX1.Jurkat 186 bp overlap
RYBP 1 dataset
ChIP WA01 GSE104690.RYBP.WA01 183 bp overlap
SMAD1 1 dataset
ChIP Hep-G2 ENCSR213QOZ.SMAD1.Hep-G2 240 bp overlap
SMAD2-3 2 datasets
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 324 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 390 bp overlap
SMAD2_3 1 dataset
ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 378 bp overlap
SMAD3 2 datasets
ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 151 bp overlap
ChIP hESC GSE29422.SMAD3.hESC 152 bp overlap
SMARCA4 2 datasets
ChIP NSC GSE125033.SMARCA4.NSC 246 bp overlap
ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 230 bp overlap
SMARCC1 1 dataset
ChIP hiPSC GSE124903.SMARCC1.hiPSC 157 bp overlap
SS18 1 dataset
ChIP SYO-1 GSE108025.SS18.SYO-1 271 bp overlap
SUZ12 2 datasets
ChIP H1 ENCFF881NFR 390 bp overlap
ChIP WA01 ENCSR000ATS.SUZ12.WA01 304 bp overlap
TFAP2C 2 datasets
ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 255 bp overlap
ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 327 bp overlap
TRIM28 1 dataset
ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 221 bp overlap
ZNF550 1 dataset
ChIP Hep-G2 ENCSR198BHH.ZNF550.Hep-G2 277 bp overlap
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