chr20:45,376,274–45,377,532

chr20 : 45,376,274 – 45,377,532

1,258 bp 52 TFs 6 linked genes

This 1.3 kb open chromatin element is linked to 6 target genes and is bound by 52 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TP53TG5		792 bp	At TSS	Proximity
SYS1		13.4 kb	Distal	Multiome
SDC4		28.2 kb	Distal	Multiome
DBNDD2		29.6 kb	Distal	Multiome
PIGT		39.6 kb	Distal	Multiome
WFDC2		93.2 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

52 transcription factors

ChIP MCF-7_DMSO_45min GSE90550.AHR.MCF-7_DMSO_45min 174 bp overlap

ChIP MCF-7_TCDD_45min GSE90550.AHR.MCF-7_TCDD_45min 235 bp overlap

ChIP MCF-7 ERP001226.AR.MCF-7 232 bp overlap

ARID1A 2 datasets

ChIP MCF-7_4-hydroxytamoxifen GSE123284.ARID1A.MCF-7_4-hydroxytamoxifen 461 bp overlap

ChIP MCF-7_JQ1 GSE123284.ARID1A.MCF-7_JQ1 251 bp overlap

ARID2 2 datasets

ChIP Aska-SS_shSSX GSE108025.ARID2.Aska-SS_shSSX 540 bp overlap

ChIP MCF-7_parental GSE123284.ARID2.MCF-7_parental 223 bp overlap

CREBBP 1 dataset

ChIP MCF-7 ERP000901.CREBBP.MCF-7 182 bp overlap

CTBP1 2 datasets

ChIP MCF-7 ENCFF969VBY 417 bp overlap

ChIP MCF-7 ENCSR636EYA.CTBP1.MCF-7 269 bp overlap

CTBP2 1 dataset

ChIP MCF-7 GSE107013.CTBP2.MCF-7 153 bp overlap

CTCF 5 datasets

ChIP HT-1080 GSE135580.CTCF.HT-1080 235 bp overlap

ChIP thyroid gland ENCFF204HWS 253 bp overlap

ChIP thyroid gland ENCFF631QRY 313 bp overlap

ChIP thyroid-gland ENCSR492ZIW.CTCF.thyroid-gland 219 bp overlap

ChIP thyroid-gland ENCSR955BIB.CTCF.thyroid-gland 203 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF274GAT 192 bp overlap

ChIP BLaER1 ENCFF460KDD 279 bp overlap

ChIP MCF-7 GSE97661.DPF1.MCF-7 126 bp overlap

E2F1 2 datasets

ChIP MCF-7 ENCFF692OYJ 651 bp overlap

ChIP MCF-7 ENCSR000EWX.E2F1.MCF-7 366 bp overlap

EP300 2 datasets

ChIP MCF-7 ENCFF508OAU 311 bp overlap

ChIP MCF-7 ENCSR000BTR.EP300.MCF-7 138 bp overlap

ESR1 106 datasets

ChIP Ishikawa_E2 GSE132426.ESR1.Ishikawa_E2 162 bp overlap

ChIP Ishikawa_E2_D538G_clone2 GSE132426.ESR1.Ishikawa_E2_D538G_clone2 250 bp overlap

ChIP MCF-7 ENCFF004AKH 201 bp overlap

ChIP MCF-7 GSE128445.ESR1.MCF-7 317 bp overlap

ChIP MCF-7 GSE103023.ESR1.MCF-7 298 bp overlap

ChIP MCF-7 GSE76893.ESR1.MCF-7 329 bp overlap

ChIP MCF-7 GSE68355.ESR1.MCF-7 352 bp overlap

ChIP MCF-7 GSE117492.ESR1.MCF-7 242 bp overlap

ChIP MCF-7 GSE95302.ESR1.MCF-7 224 bp overlap

ChIP MCF-7 GSE41561.ESR1.MCF-7 232 bp overlap

ChIP MCF-7 GSE45822.ESR1.MCF-7 174 bp overlap

ChIP MCF-7 ERP000209.ESR1.MCF-7 199 bp overlap

ChIP MCF-7 GSE119702.ESR1.MCF-7 150 bp overlap

ChIP MCF-7L_t0 GSE108787.ESR1.MCF-7L_t0 296 bp overlap

ChIP MCF-7L_t1 GSE108787.ESR1.MCF-7L_t1 286 bp overlap

ChIP MCF-7L_t16 GSE108787.ESR1.MCF-7L_t16 330 bp overlap

ChIP MCF-7_ARID1A-KO GSE123284.ESR1.MCF-7_ARID1A-KO 173 bp overlap

ChIP MCF-7_ARID1A-KO_4-OHT_clone14 GSE123284.ESR1.MCF-7_ARID1A-KO_4-OHT_clone14 191 bp overlap

ChIP MCF-7_ARID1A-KO_clone14 GSE123284.ESR1.MCF-7_ARID1A-KO_clone14 300 bp overlap

ChIP MCF-7_AZD2014 GSE103023.ESR1.MCF-7_AZD2014 275 bp overlap

ChIP MCF-7_D538G GSE148277.ESR1.MCF-7_D538G 435 bp overlap

ChIP MCF-7_D538G_DMSO GSE148277.ESR1.MCF-7_D538G_DMSO 344 bp overlap

ChIP MCF-7_DMSO GSE125594.ESR1.MCF-7_DMSO 258 bp overlap

ChIP MCF-7_E2 GSE108883.ESR1.MCF-7_E2 302 bp overlap

ChIP MCF-7_E2 GSE117941.ESR1.MCF-7_E2 273 bp overlap

ChIP MCF-7_E2 GSE59530.ESR1.MCF-7_E2 188 bp overlap

ChIP MCF-7_E2 GSE102410.ESR1.MCF-7_E2 236 bp overlap

ChIP MCF-7_E2 GSE72249.ESR1.MCF-7_E2 231 bp overlap

ChIP MCF-7_E2 ERP000209.ESR1.MCF-7_E2 213 bp overlap

ChIP MCF-7_E2 GSE119702.ESR1.MCF-7_E2 150 bp overlap

ChIP MCF-7_E2+4OHT GSE119702.ESR1.MCF-7_E2+4OHT 224 bp overlap

ChIP MCF-7_E2-10min-ERalpha GSE94023.ESR1.MCF-7_E2-10min-ERalpha 213 bp overlap

ChIP MCF-7_E2-1280-min-ERalpha GSE94023.ESR1.MCF-7_E2-1280-min-ERalpha 277 bp overlap

ChIP MCF-7_E2-20min-ERalpha GSE94023.ESR1.MCF-7_E2-20min-ERalpha 186 bp overlap

ChIP MCF-7_E2-320min-ERalpha GSE94023.ESR1.MCF-7_E2-320min-ERalpha 140 bp overlap

ChIP MCF-7_E2-40min-ERalpha GSE94023.ESR1.MCF-7_E2-40min-ERalpha 214 bp overlap

ChIP MCF-7_E2-5min-ERalpha GSE94023.ESR1.MCF-7_E2-5min-ERalpha 210 bp overlap

ChIP MCF-7_E2-80min-ERalpha GSE94023.ESR1.MCF-7_E2-80min-ERalpha 195 bp overlap

ChIP MCF-7_E2_10M GSE54855.ESR1.MCF-7_E2_10M 255 bp overlap

ChIP MCF-7_E2_30min GSE108883.ESR1.MCF-7_E2_30min 548 bp overlap

ChIP MCF-7_E2_45min GSE109820.ESR1.MCF-7_E2_45min 185 bp overlap

ChIP MCF-7_E2_5M GSE54855.ESR1.MCF-7_E2_5M 195 bp overlap

ChIP MCF-7_E2_90min GSE109820.ESR1.MCF-7_E2_90min 252 bp overlap

ChIP MCF-7_E2_talen GSE94493.ESR1.MCF-7_E2_talen 205 bp overlap

ChIP MCF-7_ESR1_wildtype GSE100074.ESR1.MCF-7_ESR1_wildtype 279 bp overlap

ChIP MCF-7_Fulv GSE117941.ESR1.MCF-7_Fulv 252 bp overlap

ChIP MCF-7_G6274 GSE117941.ESR1.MCF-7_G6274 300 bp overlap

ChIP MCF-7_GLYC ERP002305.ESR1.MCF-7_GLYC 127 bp overlap

ChIP MCF-7_H3B-5942 GSE115607.ESR1.MCF-7_H3B-5942 298 bp overlap

ChIP MCF-7_HC11 GSE102882.ESR1.MCF-7_HC11 329 bp overlap

ChIP MCF-7_ICI GSE108883.ESR1.MCF-7_ICI 283 bp overlap

ChIP MCF-7_ICI GSE125594.ESR1.MCF-7_ICI 279 bp overlap

ChIP MCF-7_ICI_30min GSE108883.ESR1.MCF-7_ICI_30min 280 bp overlap

ChIP MCF-7_OBHS GSE133941.ESR1.MCF-7_OBHS 303 bp overlap

ChIP MCF-7_OHT GSE119702.ESR1.MCF-7_OHT 224 bp overlap

ChIP MCF-7_PROG GSE68355.ESR1.MCF-7_PROG 363 bp overlap

ChIP MCF-7_R5020 GSE68355.ESR1.MCF-7_R5020 346 bp overlap

ChIP MCF-7_RAD001 GSE103023.ESR1.MCF-7_RAD001 355 bp overlap

ChIP MCF-7_SHCRT_E2 ERP000380.ESR1.MCF-7_SHCRT_E2 167 bp overlap

ChIP MCF-7_SHFOXA1_E2 ERP000380.ESR1.MCF-7_SHFOXA1_E2 158 bp overlap

ChIP MCF-7_SHFOXA1_E2_TNF GSE59530.ESR1.MCF-7_SHFOXA1_E2_TNF 143 bp overlap

ChIP MCF-7_SICTR_E2 GSE40129.ESR1.MCF-7_SICTR_E2 159 bp overlap

ChIP MCF-7_SIGATA_E2 GSE40129.ESR1.MCF-7_SIGATA_E2 161 bp overlap

ChIP MCF-7_Tamoxifen GSE102410.ESR1.MCF-7_Tamoxifen 252 bp overlap

ChIP MCF-7_Veh GSE95302.ESR1.MCF-7_Veh 162 bp overlap

ChIP MCF-7_Veh_sc GSE117569.ESR1.MCF-7_Veh_sc 463 bp overlap

ChIP MCF-7_Y537S_DMSO GSE148277.ESR1.MCF-7_Y537S_DMSO 253 bp overlap

ChIP MCF-7_estradiol-DHT_45min GSE99626.ESR1.MCF-7_estradiol-DHT_45min 332 bp overlap

ChIP MCF-7_estradiol-DHT_4h GSE99626.ESR1.MCF-7_estradiol-DHT_4h 457 bp overlap

ChIP MCF-7_estradiol-Dex_4h GSE99626.ESR1.MCF-7_estradiol-Dex_4h 334 bp overlap

ChIP MCF-7_estradiol-Dex_75min GSE99626.ESR1.MCF-7_estradiol-Dex_75min 114 bp overlap

ChIP MCF-7_estradiol-aldosterone_4h GSE99626.ESR1.MCF-7_estradiol-aldosterone_4h 292 bp overlap

ChIP MCF-7_estradiol-progesterone_4h GSE99626.ESR1.MCF-7_estradiol-progesterone_4h 368 bp overlap

ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 475 bp overlap

ChIP MCF-7_estradiol_4h GSE99626.ESR1.MCF-7_estradiol_4h 181 bp overlap

ChIP MCF-7_estrogen GSE133941.ESR1.MCF-7_estrogen 346 bp overlap

ChIP MCF-7_jc5849 GSE126004.ESR1.MCF-7_jc5849 242 bp overlap

ChIP MCF-7_parental GSE123284.ESR1.MCF-7_parental 388 bp overlap

ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.ESR1.MCF-7_parental_4-hydroxytamoxifen 298 bp overlap

ChIP MCF-7_shCtrl GSE125594.ESR1.MCF-7_shCtrl 182 bp overlap

ChIP MCF-7_shFbxo GSE119702.ESR1.MCF-7_shFbxo 161 bp overlap

ChIP MCF-7_shFbxo_E2 GSE119702.ESR1.MCF-7_shFbxo_E2 161 bp overlap

ChIP MCF-7_shFbxo_E2_4OHT GSE119702.ESR1.MCF-7_shFbxo_E2_4OHT 210 bp overlap

ChIP MCF-7_shFbxo_E2_4OHT_SRC-3 GSE119702.ESR1.MCF-7_shFbxo_E2_4OHT_SRC-3 162 bp overlap

ChIP MCF-7_shFbxo_E2_SRC-3 GSE119702.ESR1.MCF-7_shFbxo_E2_SRC-3 207 bp overlap

ChIP MCF-7_shFbxo_OHT GSE119702.ESR1.MCF-7_shFbxo_OHT 210 bp overlap

ChIP MCF-7_shFbxo_OHT_SRC-3 GSE119702.ESR1.MCF-7_shFbxo_OHT_SRC-3 162 bp overlap

ChIP MCF-7_shFbxo_SRC-3 GSE119702.ESR1.MCF-7_shFbxo_SRC-3 207 bp overlap

ChIP MCF-7_shKMT2C GSE100328.ESR1.MCF-7_shKMT2C 232 bp overlap

ChIP MCF-7_shKMT2C_R GSE100328.ESR1.MCF-7_shKMT2C_R 234 bp overlap

ChIP MCF-7_shTEAD4 GSE125594.ESR1.MCF-7_shTEAD4 225 bp overlap

ChIP MCF-7_vehicle_4h GSE99626.ESR1.MCF-7_vehicle_4h 259 bp overlap

ChIP MDA-MB-134-VI_E2 GSE109103.ESR1.MDA-MB-134-VI_E2 209 bp overlap

ChIP breast-cancer_3487 GSE126004.ESR1.breast-cancer_3487 182 bp overlap

ChIP breast-cancer_S440-2187 GSE128018.ESR1.breast-cancer_S440-2187 232 bp overlap

ChIP breast_tumor_Female_2 GSE104399.ESR1.breast_tumor_Female_2 538 bp overlap

ChIP breast_tumor_Female_8 GSE104399.ESR1.breast_tumor_Female_8 164 bp overlap

ChIP breast_tumor_Male_10 GSE104399.ESR1.breast_tumor_Male_10 718 bp overlap

ChIP breast_tumor_Male_13 GSE104399.ESR1.breast_tumor_Male_13 228 bp overlap

ChIP breast_tumor_Male_14 GSE104399.ESR1.breast_tumor_Male_14 206 bp overlap

ChIP breast_tumor_Male_18 GSE104399.ESR1.breast_tumor_Male_18 204 bp overlap

ChIP breast_tumor_Male_19 GSE104399.ESR1.breast_tumor_Male_19 263 bp overlap

ChIP breast_tumor_Male_5 GSE104399.ESR1.breast_tumor_Male_5 335 bp overlap

ChIP breast_tumor_Male_7 GSE104399.ESR1.breast_tumor_Male_7 224 bp overlap

ChIP pleural-effusion GSE86538.ESR1.pleural-effusion 179 bp overlap

ChIP primary-endometrium-cancer_E1_DSG GSE114737.ESR1.primary-endometrium-cancer_E1_DSG 206 bp overlap

ESR1_D538G 1 dataset

ChIP MCF-7_dox_E2 GSE94493.ESR1_D538G.MCF-7_dox_E2 188 bp overlap

ESR1_Y537N 3 datasets

ChIP MCF-7_E2_talen GSE94493.ESR1_Y537N.MCF-7_E2_talen 149 bp overlap

ChIP MCF-7_dox GSE94493.ESR1_Y537N.MCF-7_dox 251 bp overlap

ChIP MCF-7_talen GSE94493.ESR1_Y537N.MCF-7_talen 164 bp overlap

ESR1_Y537S 2 datasets

ChIP MCF-7_E2 GSE94493.ESR1_Y537S.MCF-7_E2 256 bp overlap

ChIP MCF-7_dox GSE94493.ESR1_Y537S.MCF-7_dox 227 bp overlap

ESR1_pS118 1 dataset

ChIP MCF-7_E2_sc GSE117569.ESR1_pS118.MCF-7_E2_sc 469 bp overlap

FOXA1 15 datasets

ChIP MCF-7 ERP001226.FOXA1.MCF-7 167 bp overlap

ChIP MCF-7 ERP000380.FOXA1.MCF-7 126 bp overlap

ChIP MCF-7_4OH-Tam GSE75201.FOXA1.MCF-7_4OH-Tam 175 bp overlap

ChIP MCF-7_E2 GSE72249.FOXA1.MCF-7_E2 218 bp overlap

ChIP MCF-7_E2 GSE23852.FOXA1.MCF-7_E2 182 bp overlap

ChIP MCF-7_E2 GSE59530.FOXA1.MCF-7_E2 149 bp overlap

ChIP MCF-7_E2_TAM ERP000380.FOXA1.MCF-7_E2_TAM 129 bp overlap

ChIP MCF-7_JC4697 GSE126004.FOXA1.MCF-7_JC4697 215 bp overlap

ChIP breast-cancer_ENOB-2849 GSE128018.FOXA1.breast-cancer_ENOB-2849 195 bp overlap

ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 241 bp overlap

ChIP breast_tumor_Female_2 GSE104399.FOXA1.breast_tumor_Female_2 211 bp overlap

ChIP breast_tumor_Female_2 GSE104399.FOXA1.breast_tumor_Female_2 274 bp overlap

ChIP breast_tumor_Male_13 GSE104399.FOXA1.breast_tumor_Male_13 223 bp overlap

ChIP primary-breast-cancer_B2_DSG GSE114737.FOXA1.primary-breast-cancer_B2_DSG 179 bp overlap

ChIP primary-breast-cancer_B2_DSG GSE114737.FOXA1.primary-breast-cancer_B2_DSG 273 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 1229 bp overlap

ChIP DE DE-FOXA2-2 523 bp overlap

ChIP DE DE-FOXA2-2 325 bp overlap

GATA3 6 datasets

ChIP MCF-7 ENCFF178GBS 461 bp overlap

ChIP MCF-7 ENCFF352QVM 259 bp overlap

ChIP MCF-7 ENCFF437NQS 371 bp overlap

ChIP MCF-7 GSE122847.GATA3.MCF-7 368 bp overlap

ChIP MCF-7 GSE51274.GATA3.MCF-7 417 bp overlap

ChIP MCF-7 GSE133072.GATA3.MCF-7 271 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 896 bp overlap

ChIP DE DE-GATA4-2 995 bp overlap

GATA6 4 datasets

ChIP DE DE-GATA6-1 1090 bp overlap

ChIP DE DE-GATA6-2 1258 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 551 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 486 bp overlap

GRHL2 2 datasets

ChIP MCF-7 GSE109820.GRHL2.MCF-7 175 bp overlap

ChIP MCF-7_E2_45min GSE109820.GRHL2.MCF-7_E2_45min 201 bp overlap

HDAC1 1 dataset

ChIP MCF-7_parental_4-hydroxytamoxifen GSE123284.HDAC1.MCF-7_parental_4-hydroxytamoxifen 362 bp overlap

HDAC2 1 dataset

ChIP MCF-7 ENCSR000BTP.HDAC2.MCF-7 140 bp overlap

MITF 4 datasets

ChIP 501-mel GSE137522.MITF.501-mel 359 bp overlap

ChIP 501-mel_20ng_K243R GSE137522.MITF.501-mel_20ng_K243R 306 bp overlap

ChIP K-562 ENCSR797SWM.MITF.K-562 335 bp overlap

ChIP K562 ENCFF731XJJ 425 bp overlap

NCOA2 1 dataset

ChIP MCF-7_E2 ERP000901.NCOA2.MCF-7_E2 144 bp overlap

NR2F2 2 datasets

ChIP MCF-7 ENCFF329FZB 361 bp overlap

ChIP MCF-7 ENCSR000BUY.NR2F2.MCF-7 254 bp overlap

NRIP1 2 datasets

ChIP MCF-7 ERP005838.NRIP1.MCF-7 192 bp overlap

ChIP MCF-7_E2 ERP005838.NRIP1.MCF-7_E2 177 bp overlap

ChIP MCF-7_PROG GSE68355.PGR.MCF-7_PROG 201 bp overlap

RAD21 2 datasets

ChIP MCF-7 ENCFF724VCQ 257 bp overlap

ChIP MCF-7 ENCSR703TNG.RAD21.MCF-7 142 bp overlap

RAD51 2 datasets

ChIP MCF-7 ENCFF128SEB 397 bp overlap

ChIP MCF-7 ENCSR442VBJ.RAD51.MCF-7 306 bp overlap

ChIP MCF-7 ENCFF973QAD 405 bp overlap

RUNX1 1 dataset

ChIP epididymis_HEE GSE109061.RUNX1.epididymis_HEE 115 bp overlap

SIN3A 2 datasets

ChIP MCF-7 ENCFF521RDC 477 bp overlap

ChIP MCF-7 ENCSR000BUM.SIN3A.MCF-7 280 bp overlap

SIX2 2 datasets

ChIP HEK GSE73865.SIX2.HEK 63 bp overlap

ChIP kidney_fetal_16w GSE75948.SIX2.kidney_fetal_16w 50 bp overlap

SMAD2-3 1 dataset

ChIP HGrC1_C134W-TGF GSE138496.SMAD2-3.HGrC1_C134W-TGF 181 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 796 bp overlap

SMARCA4 1 dataset

ChIP MCF-7 GSE140185.SMARCA4.MCF-7 370 bp overlap

SMARCB1 2 datasets

ChIP MCF-7_4-hydroxytamoxifen GSE123284.SMARCB1.MCF-7_4-hydroxytamoxifen 322 bp overlap

ChIP MCF-7_estrogen GSE123284.SMARCB1.MCF-7_estrogen 244 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 310 bp overlap

SRSF3 1 dataset

ChIP K-562 GSE120104.SRSF3.K-562 143 bp overlap

STAT3 1 dataset

ChIP breast-cancer_3487 GSE126004.STAT3.breast-cancer_3487 192 bp overlap

TFAP2A 1 dataset

ChIP MCF-7_E2 GSE60270.TFAP2A.MCF-7_E2 169 bp overlap

TFAP2C 2 datasets

ChIP MCF-7_E2 GSE23852.TFAP2C.MCF-7_E2 261 bp overlap

ChIP MCF-7_ETOH GSE23852.TFAP2C.MCF-7_ETOH 254 bp overlap

ChIP K562 ENCFF697ABG 317 bp overlap

ChIP MCF-7 ENCFF544WQF 102 bp overlap

TRPS1 1 dataset

ChIP MCF-7 GSE133072.TRPS1.MCF-7 165 bp overlap

ChIP WA01 ENCSR000BIU.USF1.WA01 129 bp overlap

XRCC5 1 dataset

ChIP K-562 GSE120104.XRCC5.K-562 146 bp overlap

ZNF217 1 dataset

ChIP MCF-7 ENCFF299BWK 557 bp overlap

ChIP MCF-7 GSE97661.ZXDC.MCF-7 186 bp overlap