chr16:70,457,673–70,458,151

chr16 : 70,457,673 – 70,458,151

478 bp 38 TFs 11 linked genes

This 478 bp open chromatin element is linked to 11 target genes and is bound by 38 transcription factors.

Linked Genes

11 genes

Gene	Expression	Dist. to TSS	Distance	Link type
FCSK		3.1 kb	Proximal	Proximity
ST3GAL2		18.9 kb	Distal	Multiome
COG4		65.6 kb	Distal	Multiome
SF3B3		65.8 kb	Distal	Multiome
DDX19A		111.1 kb	Distal	Multiome
DDX19A-DT		111.2 kb	Distal	Multiome
DDX19B		158.8 kb	Distal	Multiome
AARS1		168.4 kb	Distal	Multiome
IL34		188.6 kb	Distal	Multiome
EXOSC6		206.0 kb	Distal	Multiome
MTSS2		228.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

38 transcription factors

ChIP A-375 GSE116189.AR.A-375 155 bp overlap

ChIP SK-MEL-28 GSE85352.ARNT.SK-MEL-28 242 bp overlap

CBFA2T2 2 datasets

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 251 bp overlap

ChIP K562 ENCFF963TXY 363 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 280 bp overlap

ChIP K562 ENCFF673OEZ 322 bp overlap

CDK9 2 datasets

ChIP A-375_A771726 GSE68052.CDK9.A-375_A771726 83 bp overlap

ChIP A-375_A771726 GSE57431.CDK9.A-375_A771726 65 bp overlap

CEBPB 2 datasets

ChIP K-562 ENCSR000BRQ.CEBPB.K-562 177 bp overlap

ChIP K-562 ENCSR000EHE.CEBPB.K-562 182 bp overlap

CEBPD 1 dataset

ChIP K-562 ENCSR000BVY.CEBPD.K-562 148 bp overlap

ChIP Peyers-patch ENCSR375VXU.CTCF.Peyers-patch 215 bp overlap

ChIP NTERA2 GSE58641.DDX5.NTERA2 297 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 215 bp overlap

ChIP A-375 GSE80443.ETV1.A-375 111 bp overlap

FOXA2 1 dataset

ChIP DE DE-FOXA2-2 286 bp overlap

GATA1 4 datasets

ChIP CD34_ERYTH_BIO GSE29194.GATA1.CD34_ERYTH_BIO 124 bp overlap

ChIP CD34_ERYTH_BMP GSE29194.GATA1.CD34_ERYTH_BMP 116 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 208 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 160 bp overlap

GATA1::TAL1 2 datasets

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 2 datasets

Motif DE_60h DE_60h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

GATA4 5 datasets

ChIP DE DE-GATA4-1 458 bp overlap

ChIP DE DE-GATA4-2 478 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 286 bp overlap

GATA6 15 datasets

ChIP AGS GSE51705.GATA6.AGS 162 bp overlap

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 281 bp overlap

ChIP DE DE-GATA6-1 405 bp overlap

ChIP DE DE-GATA6-2 477 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 343 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 416 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 364 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 470 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 296 bp overlap

Gata3 6 datasets

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HEXIM1 1 dataset

ChIP A-375_DMSO GSE68052.HEXIM1.A-375_DMSO 80 bp overlap

HNF4A 1 dataset

ChIP Caco-2_PROLIF GSE23436.HNF4A.Caco-2_PROLIF 125 bp overlap

Hmga1 2 datasets

Motif DE_60h DE_60h-Hmga1_MA2124.1 8 bp overlap

Motif DE_72h DE_72h-Hmga1_MA2124.1 8 bp overlap

KDM5B 1 dataset

ChIP HCC2157 GSE46055.KDM5B.HCC2157 54 bp overlap

NKX2-3 2 datasets

Motif DE_60h DE_60h-NKX2-3_MA0672.2 8 bp overlap

Motif DE_72h DE_72h-NKX2-3_MA0672.2 8 bp overlap

NKX2-4 2 datasets

Motif DE_60h DE_60h-NKX2-4_MA2003.2 8 bp overlap

Motif DE_72h DE_72h-NKX2-4_MA2003.2 8 bp overlap

NKX2-8 2 datasets

Motif DE_60h DE_60h-NKX2-8_MA0673.2 8 bp overlap

Motif DE_72h DE_72h-NKX2-8_MA0673.2 8 bp overlap

ChIP HepG2 ENCFF763IEA 99 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 394 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 340 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 269 bp overlap

SMAD4 1 dataset

ChIP Caco-2 GSE112946.SMAD4.Caco-2 125 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 214 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 299 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

TAL1 4 datasets

ChIP K-562 GSE107726.TAL1.K-562 270 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 192 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 182 bp overlap

ChIP K-562_sgGal4 GSE132212.TAL1.K-562_sgGal4 144 bp overlap

TRPS1 6 datasets

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ZGPAT 1 dataset

ChIP Hep-G2 ENCSR704IGU.ZGPAT.Hep-G2 120 bp overlap

ZNF343 2 datasets

Motif DE_60h DE_60h-ZNF343_MA1711.2 16 bp overlap

Motif DE_72h DE_72h-ZNF343_MA1711.2 16 bp overlap

ZNF382 2 datasets

Motif DE_60h DE_60h-ZNF382_MA1594.1 24 bp overlap

Motif DE_72h DE_72h-ZNF382_MA1594.1 24 bp overlap

ZNF454 2 datasets

Motif DE_60h DE_60h-ZNF454_MA1712.2 17 bp overlap

Motif DE_72h DE_72h-ZNF454_MA1712.2 17 bp overlap