The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ST3GAL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST3GAL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST3GAL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:70,250,987–70,252,565 | 187.2 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:70,288,832–70,289,863 | 149.6 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:70,346,498–70,347,297 | 92.3 kb | Distal (>10kb) Multiome | 945 | |
| chr16:70,380,270–70,382,056 | 57.6 kb | Distal (>10kb) Multiome | 1036 | |
| chr16:70,415,208–70,415,782 | 23.7 kb | Distal (>10kb) Multiome | 229 | |
| chr16:70,427,766–70,429,282 | 10.7 kb | Distal (>10kb) Multiome | 981 | |
| chr16:70,431,040–70,431,529 | 8.0 kb | Proximal (<10kb) Multiome | 302 | |
| chr16:70,436,957–70,437,432 | 1.9 kb | Proximal (<10kb) Multiome | 457 | |
| chr16:70,437,705–70,438,289 | 810 bp | At TSS | 281 | |
| chr16:70,438,422–70,439,873 | 156 bp | At TSS Multiome | 926 | |
| chr16:70,454,276–70,454,976 | 15.4 kb | Distal (>10kb) Multiome | 845 | |
| chr16:70,457,673–70,458,151 | 18.9 kb | Distal (>10kb) Multiome | 38 | |
| chr16:70,523,103–70,524,281 | 84.6 kb | Distal (>10kb) Multiome | 903 | |
| chr16:70,679,595–70,680,466 | 241.0 kb | Distal (>10kb) Multiome | 216 | |
| chr16:70,685,497–70,686,558 | 247.0 kb | Distal (>10kb) Multiome | 655 |
Genomic view of the ST3GAL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.