Enables GTPase activator activity and small GTPase binding activity. Involved in activation of GTPase activity and cellular response to platelet-derived growth factor stimulus. Located in ruffle membrane. Implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTSS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTSS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTSS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:70,415,208–70,415,782 | 270.6 kb | Distal (>10kb) Multiome | 229 | |
| chr16:70,427,766–70,429,282 | 257.6 kb | Distal (>10kb) Multiome | 981 | |
| chr16:70,431,040–70,431,529 | 254.9 kb | Distal (>10kb) Multiome | 302 | |
| chr16:70,436,957–70,437,432 | 248.8 kb | Distal (>10kb) Multiome | 457 | |
| chr16:70,438,422–70,439,873 | 246.8 kb | Distal (>10kb) Multiome | 926 | |
| chr16:70,454,276–70,454,976 | 231.5 kb | Distal (>10kb) Multiome | 845 | |
| chr16:70,457,673–70,458,151 | 228.1 kb | Distal (>10kb) Multiome | 38 | |
| chr16:70,523,103–70,524,281 | 162.3 kb | Distal (>10kb) Multiome | 903 | |
| chr16:70,679,595–70,680,466 | 5.9 kb | Proximal (<10kb) Multiome | 216 | |
| chr16:70,685,497–70,686,558 | 37 bp | At TSS Multiome | 655 | |
| chr16:70,800,702–70,801,519 | 115.1 kb | Distal (>10kb) Multiome | 768 | |
| chr16:71,358,510–71,359,053 | 672.6 kb | Distal (>10kb) Multiome HiCAR | 387 | |
| chr16:71,412,167–71,413,209 | 726.6 kb | Distal (>10kb) Multiome HiCAR | 349 |
Genomic view of the MTSS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.