The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FCSK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FCSK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FCSK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:70,250,987–70,252,565 | 202.7 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:70,288,832–70,289,863 | 165.1 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:70,346,498–70,347,297 | 107.7 kb | Distal (>10kb) Multiome | 945 | |
| chr16:70,380,270–70,382,056 | 73.1 kb | Distal (>10kb) Multiome HiCAR | 1036 | |
| chr16:70,415,208–70,415,782 | 39.2 kb | Distal (>10kb) Multiome | 229 | |
| chr16:70,427,766–70,429,282 | 26.2 kb | Distal (>10kb) Multiome | 981 | |
| chr16:70,431,040–70,431,529 | 23.5 kb | Distal (>10kb) Multiome | 302 | |
| chr16:70,436,957–70,437,432 | 17.4 kb | Distal (>10kb) Multiome | 457 | |
| chr16:70,438,422–70,439,873 | 15.3 kb | Distal (>10kb) Multiome | 926 | |
| chr16:70,450,277–70,450,617 | 4.0 kb | Proximal (<10kb) | 34 | |
| chr16:70,454,276–70,454,976 | 58 bp | At TSS Multiome | 845 | |
| chr16:70,457,673–70,458,151 | 3.4 kb | Proximal (<10kb) Multiome | 38 | |
| chr16:70,460,679–70,460,962 | 6.1 kb | Proximal (<10kb) | 55 | |
| chr16:70,523,103–70,524,281 | 69.1 kb | Distal (>10kb) Multiome | 903 | |
| chr16:70,679,595–70,680,466 | 225.5 kb | Distal (>10kb) Multiome | 216 | |
| chr16:70,685,497–70,686,558 | 231.5 kb | Distal (>10kb) Multiome | 655 |
Genomic view of the FCSK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.