This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EXOSC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOSC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOSC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:70,065,697–70,066,412 | 186.0 kb | Distal (>10kb) Multiome | 331 | |
| chr16:70,114,104–70,114,595 | 137.6 kb | Distal (>10kb) Multiome | 324 | |
| chr16:70,250,987–70,252,565 | 25 bp | At TSS Multiome | 1128 | |
| chr16:70,252,688–70,252,867 | 748 bp | At TSS | 205 | |
| chr16:70,253,903–70,254,089 | 2.0 kb | Proximal (<10kb) | 134 | |
| chr16:70,288,832–70,289,863 | 37.6 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:70,346,498–70,347,297 | 94.9 kb | Distal (>10kb) Multiome | 945 | |
| chr16:70,380,270–70,382,056 | 129.5 kb | Distal (>10kb) Multiome | 1036 | |
| chr16:70,415,208–70,415,782 | 163.5 kb | Distal (>10kb) Multiome | 229 | |
| chr16:70,427,766–70,429,282 | 176.5 kb | Distal (>10kb) Multiome | 981 | |
| chr16:70,431,040–70,431,529 | 179.2 kb | Distal (>10kb) Multiome | 302 | |
| chr16:70,436,957–70,437,432 | 185.3 kb | Distal (>10kb) Multiome | 457 | |
| chr16:70,438,422–70,439,873 | 187.3 kb | Distal (>10kb) Multiome | 926 | |
| chr16:70,454,276–70,454,976 | 202.6 kb | Distal (>10kb) Multiome | 845 | |
| chr16:70,457,673–70,458,151 | 206.0 kb | Distal (>10kb) Multiome | 38 | |
| chr16:70,523,103–70,524,281 | 271.8 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the EXOSC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.