Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DDX19A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDX19A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDX19A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:70,065,697–70,066,412 | 280.9 kb | Distal (>10kb) Multiome | 331 | |
| chr16:70,114,104–70,114,595 | 232.6 kb | Distal (>10kb) Multiome | 324 | |
| chr16:70,250,987–70,252,565 | 95.0 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:70,288,832–70,289,863 | 57.4 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:70,346,498–70,347,297 | 46 bp | At TSS Multiome | 945 | |
| chr16:70,380,270–70,382,056 | 34.6 kb | Distal (>10kb) Multiome | 1036 | |
| chr16:70,415,208–70,415,782 | 68.5 kb | Distal (>10kb) Multiome | 229 | |
| chr16:70,427,766–70,429,282 | 81.5 kb | Distal (>10kb) Multiome | 981 | |
| chr16:70,431,040–70,431,529 | 84.2 kb | Distal (>10kb) Multiome | 302 | |
| chr16:70,436,957–70,437,432 | 90.3 kb | Distal (>10kb) Multiome | 457 | |
| chr16:70,438,422–70,439,873 | 92.4 kb | Distal (>10kb) Multiome | 926 | |
| chr16:70,454,276–70,454,976 | 107.6 kb | Distal (>10kb) Multiome | 845 | |
| chr16:70,457,673–70,458,151 | 111.1 kb | Distal (>10kb) Multiome | 38 | |
| chr16:70,523,103–70,524,281 | 176.8 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the DDX19A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.