chr12 : 49,228,702 – 49,229,259
557 bp 64 TFs 12 linked genes
This 557 bp open chromatin element is linked to 12 target genes and is bound by 64 transcription factors.
Linked Genes
12 genes
Link type
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
ENSG00000258101 35.8 kb Distal Multiome
TUBA1C 36.2 kb Distal Multiome
TUBA1A 39.8 kb Distal Multiome+HiCAR
TROAP 94.3 kb Distal Multiome
TUBA1B 97.5 kb Distal Multiome
TUBA1B-AS1 98.0 kb Distal Multiome
LMBR1L 118.0 kb Distal Multiome
SPATS2 138.0 kb Distal Multiome
KMT2D 168.1 kb Distal Multiome
DDN-AS1 210.0 kb Distal Multiome
PRKAG1 210.2 kb Distal Multiome
ARF3 271.4 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr12:49,223,702 – 49,234,259
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
64 transcription factors
Source
Cell type
Arid3a 2 datasets
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap
BRD4 2 datasets
ChIP SK-N-BE2-C_Resistant-veh GSE107706.BRD4.SK-N-BE2-C_Resistant-veh 148 bp overlap
ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 454 bp overlap
CBFA2T3 1 dataset
ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 236 bp overlap
CEBPD 1 dataset
ChIP K-562 ENCSR000BVY.CEBPD.K-562 126 bp overlap
Crx 2 datasets
Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap
Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap
EBF1 2 datasets
Motif DE_48h DE_48h-EBF1_MA0154.5 11 bp overlap
Motif DE_72h DE_72h-EBF1_MA0154.5 11 bp overlap
EGR2 1 dataset
ChIP HEK293 ENCFF336LFH 117 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 464 bp overlap
ESRRA 2 datasets
Motif DE_48h DE_48h-ESRRA_MA0592.4 9 bp overlap
Motif DE_72h DE_72h-ESRRA_MA0592.4 9 bp overlap
ESRRG 1 dataset
ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 336 bp overlap
ETS1 1 dataset
ChIP cardiomyocyte_D2 GSE129986.ETS1.cardiomyocyte_D2 290 bp overlap
Ebf4 2 datasets
Motif DE_48h DE_48h-Ebf4_MA2122.1 11 bp overlap
Motif DE_72h DE_72h-Ebf4_MA2122.1 11 bp overlap
Esrrg 2 datasets
Motif DE_48h DE_48h-Esrrg_MA0643.2 9 bp overlap
Motif DE_72h DE_72h-Esrrg_MA0643.2 9 bp overlap
FOXA1 2 datasets
ChIP 22Rv1_CST_Crispr-70 GSE123618.FOXA1.22Rv1_CST_Crispr-70 193 bp overlap
ChIP MCF-7 GSE140185.FOXA1.MCF-7 201 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 537 bp overlap
ChIP DE DE-FOXA2-2 413 bp overlap
GATA1 1 dataset
ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 156 bp overlap
GATA1::TAL1 2 datasets
Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap
GATA2 3 datasets
Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap
Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap
ChIP K-562 ENCSR000EWG.GATA2.K-562 123 bp overlap
GATA4 6 datasets
ChIP DE DE-GATA4-1 557 bp overlap
ChIP DE DE-GATA4-2 557 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap
ChIP foregut GSE117136.GATA4.foregut 378 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 280 bp overlap
GATA5 4 datasets
Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap
Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap
Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap
Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap
GATA6 13 datasets
ChIP DE DE-GATA6-1 557 bp overlap
ChIP DE DE-GATA6-2 557 bp overlap
Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap
Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 557 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 557 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 557 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 557 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 557 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 557 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 557 bp overlap
ChIP foregut GSE117136.GATA6.foregut 371 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 399 bp overlap
GSC 2 datasets
Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap
Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap
GSC2 2 datasets
Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap
Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap
Gata3 2 datasets
Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap
Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap
HOXC6 1 dataset
ChIP 22Rv1 GSE129951.HOXC6.22Rv1 85 bp overlap
IKZF1 3 datasets
ChIP K-562 ENCSR395HWC.IKZF1.K-562 320 bp overlap
ChIP K562 ENCFF348IBL 374 bp overlap
ChIP K562 ENCFF771OHZ 373 bp overlap
JUN 2 datasets
ChIP DE_D2 S02-DE-d2-JUN-exp1 326 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 267 bp overlap
JUND 2 datasets
Motif DE_48h DE_48h-JUND_MA0492.2 11 bp overlap
Motif DE_72h DE_72h-JUND_MA0492.2 11 bp overlap
MYCN 1 dataset
ChIP Kelly GSE94822.MYCN.Kelly 129 bp overlap
NANOG 1 dataset
ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 282 bp overlap
NKX2-4 1 dataset
Motif DE_48h DE_48h-NKX2-4_MA2003.2 8 bp overlap
NR5A1 2 datasets
Motif DE_48h DE_48h-NR5A1_MA1540.3 12 bp overlap
Motif DE_72h DE_72h-NR5A1_MA1540.3 12 bp overlap
OTX1 2 datasets
Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap
Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap
PITX1 2 datasets
Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap
Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap
PITX2 2 datasets
Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap
Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap
PITX3 2 datasets
Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap
Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap
POU5F1 1 dataset
ChIP BJ_INDUCED GSE36570.POU5F1.BJ_INDUCED 133 bp overlap
PRDM6 1 dataset
ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 202 bp overlap
RHOXF1 2 datasets
Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 174 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 495 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 534 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 333 bp overlap
SMAD2_3 4 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 346 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 557 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 546 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 467 bp overlap
SMAD3 2 datasets
ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 136 bp overlap
ChIP endoderm GSE29422.SMAD3.endoderm 156 bp overlap
SMARCA4 1 dataset
ChIP hiPSC GSE124903.SMARCA4.hiPSC 250 bp overlap
SMARCC1 3 datasets
ChIP DE_D1 S10-DE-d1-BAF155-exp1 182 bp overlap
ChIP DE_D1 S15-DE-d1-BAF155-exp1 446 bp overlap
ChIP hiPSC GSE124903.SMARCC1.hiPSC 242 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 270 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 296 bp overlap
SP7 1 dataset
ChIP HEK293 ENCSR468IJT.SP7.HEK293 216 bp overlap
STAT1::STAT2 2 datasets
Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_72h DE_72h-STAT1STAT2_MA0517.2 13 bp overlap
T 3 datasets
ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 323 bp overlap
ChIP H9_MESODERM GSE60606.T.H9_MESODERM 235 bp overlap
ChIP H9_MESODERM GSE60606.T.H9_MESODERM 178 bp overlap
TAL1 1 dataset
ChIP K562 ENCFF661CCK 277 bp overlap
TBX2 1 dataset
ChIP Kelly GSE94822.TBX2.Kelly 178 bp overlap
TFAP2A 2 datasets
Motif DE_48h DE_48h-TFAP2A_MA0003.5 9 bp overlap
Motif DE_72h DE_72h-TFAP2A_MA0003.5 9 bp overlap
TFAP2C 2 datasets
Motif DE_48h DE_48h-TFAP2C_MA0814.3 9 bp overlap
Motif DE_72h DE_72h-TFAP2C_MA0814.3 9 bp overlap
THAP1 2 datasets
Motif DE_48h DE_48h-THAP1_MA0597.3 8 bp overlap
Motif DE_72h DE_72h-THAP1_MA0597.3 8 bp overlap
TRPS1 2 datasets
Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap
Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap
ZFHX2 1 dataset
ChIP HEK293 ENCFF167TUA 126 bp overlap
ZFP36 1 dataset
ChIP K-562 ENCSR776CYN.ZFP36.K-562 105 bp overlap
ZFP64 1 dataset
ChIP HEK293 GSE76494.ZFP64.HEK293 153 bp overlap
ZNF157 1 dataset
Motif DE_48h DE_48h-ZNF157_MA2331.1 21 bp overlap
ZNF189 2 datasets
ChIP HEK293 ENCFF638TIB 188 bp overlap
ChIP HEK293 ENCSR163RYW.ZNF189.HEK293 285 bp overlap
ZNF664 2 datasets
ChIP HEK293 ENCFF343XSW 192 bp overlap
ChIP HEK293 ENCSR714LZQ.ZNF664.HEK293 304 bp overlap
ZNF675 2 datasets
Motif DE_48h DE_48h-ZNF675_MA1714.2 19 bp overlap
Motif DE_72h DE_72h-ZNF675_MA1714.2 19 bp overlap
ZNF766 3 datasets
Motif DE_48h DE_48h-ZNF766_MA2098.1 9 bp overlap
Motif DE_72h DE_72h-ZNF766_MA2098.1 9 bp overlap
ChIP K562 ENCFF348LDO 504 bp overlap
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