Transcription factors with Perturb-seq knockdown data for ENSG00000258101. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258101 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258101, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:48,978,055–48,978,819 | 286.5 kb | Distal (>10kb) Multiome | 360 | |
| chr12:48,980,647–48,981,153 | 283.8 kb | Distal (>10kb) Multiome | 259 | |
| chr12:48,997,612–48,998,829 | 266.4 kb | Distal (>10kb) Multiome | 620 | |
| chr12:49,018,007–49,019,184 | 246.0 kb | Distal (>10kb) Multiome | 899 | |
| chr12:49,059,883–49,061,347 | 203.9 kb | Distal (>10kb) Multiome | 1060 | |
| chr12:49,069,381–49,070,589 | 194.8 kb | Distal (>10kb) Multiome | 804 | |
| chr12:49,088,153–49,088,744 | 176.3 kb | Distal (>10kb) Multiome | 473 | |
| chr12:49,109,990–49,111,248 | 153.9 kb | Distal (>10kb) Multiome | 693 | |
| chr12:49,129,851–49,132,062 | 134.4 kb | Distal (>10kb) Multiome | 1233 | |
| chr12:49,188,266–49,189,371 | 75.7 kb | Distal (>10kb) Multiome | 676 | |
| chr12:49,228,702–49,229,259 | 35.8 kb | Distal (>10kb) Multiome | 64 | |
| chr12:49,234,459–49,235,140 | 30.1 kb | Distal (>10kb) Multiome | 786 | |
| chr12:49,264,393–49,265,769 | 223 bp | At TSS Multiome | 1032 | |
| chr12:49,297,237–49,297,902 | 32.8 kb | Distal (>10kb) Multiome | 330 | |
| chr12:49,322,593–49,323,536 | 58.3 kb | Distal (>10kb) Multiome | 647 | |
| chr12:49,336,785–49,337,369 | 72.4 kb | Distal (>10kb) Multiome | 482 | |
| chr12:49,341,800–49,343,265 | 77.8 kb | Distal (>10kb) Multiome | 631 | |
| chr12:49,347,124–49,348,156 | 83.1 kb | Distal (>10kb) Multiome | 790 | |
| chr12:49,366,450–49,368,011 | 102.5 kb | Distal (>10kb) Multiome | 868 | |
| chr12:49,538,551–49,539,219 | 274.1 kb | Distal (>10kb) Multiome | 284 | |
| chr12:49,550,509–49,551,225 | 286.2 kb | Distal (>10kb) Multiome | 126 |
Genomic view of the ENSG00000258101 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.