chr13 : 46,472,249 – 46,472,986

737 bp 64 TFs 1 linked gene

This 737 bp open chromatin element is linked to ENSG00000277228 and is bound by 64 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000277228		1.3 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

64 transcription factors

CDX2 2 datasets

ChIP Caco-2_DIFF GSE23436.CDX2.Caco-2_DIFF 169 bp overlap

ChIP Caco-2_PROLIF GSE23436.CDX2.Caco-2_PROLIF 185 bp overlap

Dmrt1 1 dataset

Motif DE_36h DE_36h-Dmrt1_MA1603.2 9 bp overlap

ELK1::HOXA1 1 dataset

Motif DE_36h DE_36h-ELK1HOXA1_MA1931.1 14 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 162 bp overlap

ETV2::DRGX 1 dataset

Motif DE_36h DE_36h-ETV2DRGX_MA1940.2 12 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_36h DE_36h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV5::DRGX 1 dataset

Motif DE_36h DE_36h-ETV5DRGX_MA1944.2 12 bp overlap

ETV5::HOXA2 1 dataset

Motif DE_36h DE_36h-ETV5HOXA2_MA1948.2 12 bp overlap

FLI1::DRGX 1 dataset

Motif DE_36h DE_36h-FLI1DRGX_MA1949.2 14 bp overlap

FOXA1 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 304 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 733 bp overlap

ChIP DE DE-FOXA2-2 737 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 294 bp overlap

Foxl2 1 dataset

Motif DE_36h DE_36h-Foxl2_MA1607.2 10 bp overlap

GATA2 2 datasets

Motif DE_36h DE_36h-GATA2_MA0036.4 7 bp overlap

ChIP WA09 GSE105081.GATA2.WA09 141 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 706 bp overlap

ChIP DE DE-GATA4-2 730 bp overlap

Motif DE_36h DE_36h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 519 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 644 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 647 bp overlap

GATA6 17 datasets

ChIP AGS GSE51705.GATA6.AGS 178 bp overlap

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 211 bp overlap

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 174 bp overlap

ChIP DE DE-GATA6-1 728 bp overlap

ChIP DE DE-GATA6-2 715 bp overlap

Motif DE_36h DE_36h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 737 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 737 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 737 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 714 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 679 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 710 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 359 bp overlap

ChIP foregut GSE117136.GATA6.foregut 589 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 349 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 662 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 621 bp overlap

Gata3 1 dataset

Motif DE_36h DE_36h-Gata3_MA0037.5 8 bp overlap

HNF4A 3 datasets

ChIP Caco-2_DIFF GSE23436.HNF4A.Caco-2_DIFF 150 bp overlap

ChIP Caco-2_PROLIF GSE23436.HNF4A.Caco-2_PROLIF 139 bp overlap

Motif DE_36h DE_36h-HNF4A_MA1494.2 14 bp overlap

HOXB2::ELK1 1 dataset

Motif DE_36h DE_36h-HOXB2ELK1_MA1957.1 14 bp overlap

Hmga1 2 datasets

Motif DE_24h DE_24h-Hmga1_MA2124.1 8 bp overlap

Motif DE_36h DE_36h-Hmga1_MA2124.1 8 bp overlap

IKZF2 1 dataset

Motif DE_36h DE_36h-IKZF2_MA2326.1 6 bp overlap

ISL2 2 datasets

Motif DE_24h DE_24h-ISL2_MA0914.2 6 bp overlap

Motif DE_36h DE_36h-ISL2_MA0914.2 6 bp overlap

JUN 4 datasets

ChIP DE_D1 S08-DE-d1-JUN-exp1 511 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 363 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 525 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 478 bp overlap

JUN::JUNB 1 dataset

Motif DE_36h DE_36h-JUNJUNB_MA1132.2 8 bp overlap

KDM1A 1 dataset

ChIP pancreatic-progenitor_PP2-KDM1A-inh GSE104840.KDM1A.pancreatic-progenitor_PP2-KDM1A-inh 164 bp overlap

MEIS1 1 dataset

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

NR1H2::RXRA 1 dataset

Motif DE_36h DE_36h-NR1H2RXRA_MA0115.1 17 bp overlap

NR2F1 1 dataset

Motif DE_36h DE_36h-NR2F1_MA1537.2 13 bp overlap

Nanog 1 dataset

Motif DE_36h DE_36h-Nanog_MA2339.1 7 bp overlap

Nr2f6 1 dataset

Motif DE_36h DE_36h-Nr2f6_MA0677.2 13 bp overlap

PDX1 3 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 276 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 271 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 425 bp overlap

POU2F3 1 dataset

Motif DE_36h DE_36h-POU2F3_MA0627.3 9 bp overlap

POU3F1 1 dataset

Motif DE_36h DE_36h-POU3F1_MA0786.2 10 bp overlap

POU4F1 1 dataset

Motif DE_36h DE_36h-POU4F1_MA0790.2 12 bp overlap

POU4F2 3 datasets

Motif DE_24h DE_24h-POU4F2_MA0683.2 15 bp overlap

Motif DE_36h DE_36h-POU4F2_MA0683.2 15 bp overlap

POU4F3 1 dataset

Motif DE_36h DE_36h-POU4F3_MA0791.2 12 bp overlap

POU5F1 2 datasets

Motif DE_36h DE_36h-POU5F1_MA1115.2 7 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 577 bp overlap

Pparg::Rxra 1 dataset

Motif DE_36h DE_36h-PpargRxra_MA0065.3 13 bp overlap

RARA 1 dataset

ChIP hiPSC_D5 GSE132532.RARA.hiPSC_D5 288 bp overlap

REST 1 dataset

Motif DE_36h DE_36h-REST_MA0138.3 20 bp overlap

RXRB 1 dataset

Motif DE_36h DE_36h-RXRB_MA0855.1 14 bp overlap

RXRG 1 dataset

Motif DE_36h DE_36h-RXRG_MA0856.1 14 bp overlap

Rxra 1 dataset

Motif DE_36h DE_36h-Rxra_MA0512.2 14 bp overlap

SIX1 1 dataset

Motif DE_36h DE_36h-SIX1_MA1118.2 9 bp overlap

SIX2 1 dataset

Motif DE_36h DE_36h-SIX2_MA1119.2 11 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 254 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 672 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 665 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 680 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 694 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 655 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 392 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 483 bp overlap

SMAD4 1 dataset

ChIP Caco-2 GSE112946.SMAD4.Caco-2 196 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S10-DE-d1-BAF155-exp1 561 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 608 bp overlap

SOX10 1 dataset

Motif DE_36h DE_36h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 422 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 472 bp overlap

SOX4 1 dataset

Motif DE_36h DE_36h-SOX4_MA0867.3 8 bp overlap

SPIC 1 dataset

Motif DE_36h DE_36h-SPIC_MA0687.2 13 bp overlap

Sox11 1 dataset

Motif DE_36h DE_36h-Sox11_MA0869.3 8 bp overlap

Sox17 1 dataset

Motif DE_36h DE_36h-Sox17_MA0078.3 10 bp overlap

Sox6 1 dataset

Motif DE_36h DE_36h-Sox6_MA0515.1 10 bp overlap

Sox7 1 dataset

Motif DE_36h DE_36h-Sox7_MA2095.1 10 bp overlap

TFAP2A 1 dataset

ChIP WA09 GSE105081.TFAP2A.WA09 157 bp overlap

TRPS1 1 dataset

Motif DE_36h DE_36h-TRPS1_MA1970.2 8 bp overlap

ZEB2 1 dataset

ChIP K562 ENCFF795CMH 453 bp overlap

ZKSCAN3 2 datasets

Motif DE_24h DE_24h-ZKSCAN3_MA1973.2 14 bp overlap

Motif DE_36h DE_36h-ZKSCAN3_MA1973.2 14 bp overlap

ZNF157 1 dataset

Motif DE_36h DE_36h-ZNF157_MA2331.1 21 bp overlap

ZNF300 1 dataset

ChIP HEK293T GSE78099.ZNF300.HEK293T 107 bp overlap

ZNF708 1 dataset

Motif DE_36h DE_36h-ZNF708_MA1730.2 9 bp overlap