chr1:63,613,061–63,613,814

chr1 : 63,613,061 – 63,613,814

753 bp 42 TFs 6 linked genes

This 753 bp open chromatin element is linked to 6 target genes and is bound by 42 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PGM1		19.9 kb	Distal	Multiome
EFCAB7		89.8 kb	Distal	Multiome
ITGB3BP		90.1 kb	Distal	Multiome
ROR1		160.7 kb	Distal	Multiome
ALG6		245.7 kb	Distal	Multiome
FOXD3-AS1		290.8 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

42 transcription factors

CCAR2 2 datasets

ChIP Hep-G2 ENCSR247XFV.CCAR2.Hep-G2 131 bp overlap

ChIP Hep-G2 GSE120104.CCAR2.Hep-G2 129 bp overlap

ERF::NHLH1 1 dataset

Motif DE_48h DE_48h-ERFNHLH1_MA1938.2 16 bp overlap

ETV5::FOXO1 1 dataset

Motif DE_48h DE_48h-ETV5FOXO1_MA1947.2 10 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 406 bp overlap

ChIP DE DE-FOXA2-2 555 bp overlap

GATA4 8 datasets

ChIP DE DE-GATA4-1 493 bp overlap

ChIP DE DE-GATA4-2 753 bp overlap

ChIP G296S GSE85628.GATA4.G296S 216 bp overlap

ChIP G296S_2 GSE85628.GATA4.G296S_2 204 bp overlap

ChIP cardiomyocyte_7 GSE85628.GATA4.cardiomyocyte_7 147 bp overlap

ChIP foregut GSE117136.GATA4.foregut 282 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 295 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 306 bp overlap

GATA6 8 datasets

ChIP DE DE-GATA6-1 429 bp overlap

ChIP DE DE-GATA6-2 753 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 540 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 412 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 487 bp overlap

ChIP foregut GSE117136.GATA6.foregut 310 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 287 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 287 bp overlap

GLI3 3 datasets

Motif DE_48h DE_48h-GLI3_MA1491.3 15 bp overlap

Motif DE_60h DE_60h-GLI3_MA1491.3 15 bp overlap

Motif DE_72h DE_72h-GLI3_MA1491.3 15 bp overlap

Gli1 3 datasets

Motif DE_48h DE_48h-Gli1_MA1990.2 10 bp overlap

Motif DE_60h DE_60h-Gli1_MA1990.2 10 bp overlap

Motif DE_72h DE_72h-Gli1_MA1990.2 10 bp overlap

MEIS1 5 datasets

ChIP CHRF28811 ERR063469.MEIS1.CHRF28811 199 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MEIS2 1 dataset

Motif DE_48h DE_48h-MEIS2_MA0774.1 8 bp overlap

NKX2-1 2 datasets

ChIP H9_derived-cIN GSE99937.NKX2-1.H9_derived-cIN 95 bp overlap

ChIP H9_derived-cIN GSE99937.NKX2-1.H9_derived-cIN 171 bp overlap

NR2C2 3 datasets

Motif DE_48h DE_48h-NR2C2_MA0504.2 14 bp overlap

Motif DE_60h DE_60h-NR2C2_MA0504.2 14 bp overlap

Motif DE_72h DE_72h-NR2C2_MA0504.2 14 bp overlap

PAX5 2 datasets

ChIP GM12878 ENCSR000BHD.PAX5.GM12878 96 bp overlap

ChIP NALM-6 GSE126300.PAX5.NALM-6 162 bp overlap

PBX3 4 datasets

Motif DE_48h DE_48h-PBX3_MA1114.2 11 bp overlap

Motif DE_60h DE_60h-PBX3_MA1114.2 11 bp overlap

Motif DE_72h DE_72h-PBX3_MA1114.2 11 bp overlap

ChIP GM12878 ENCSR000BGR.PBX3.GM12878 133 bp overlap

ChIP T-47D_PROG GSE68355.PGR.T-47D_PROG 134 bp overlap

PKNOX1 7 datasets

Motif DE_48h DE_48h-PKNOX1_MA0782.3 10 bp overlap

Motif DE_60h DE_60h-PKNOX1_MA0782.3 10 bp overlap

Motif DE_72h DE_72h-PKNOX1_MA0782.3 10 bp overlap

ChIP GM12878 ENCFF589FCY 389 bp overlap

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 338 bp overlap

ChIP HEK293T ENCFF174WDB 348 bp overlap

ChIP HEK293T ENCSR233FAG.PKNOX1.HEK293T 326 bp overlap

POLR2A 1 dataset

ChIP gastrocnemius medialis ENCFF145VIB 130 bp overlap

PRPF4 1 dataset

ChIP Hep-G2 ENCSR243LNQ.PRPF4.Hep-G2 169 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 122 bp overlap

RREB1 3 datasets

Motif DE_48h DE_48h-RREB1_MA0073.2 19 bp overlap

Motif DE_60h DE_60h-RREB1_MA0073.2 19 bp overlap

Motif DE_72h DE_72h-RREB1_MA0073.2 19 bp overlap

SMAD2 3 datasets

Motif DE_48h DE_48h-SMAD2_MA1964.2 6 bp overlap

Motif DE_60h DE_60h-SMAD2_MA1964.2 6 bp overlap

Motif DE_72h DE_72h-SMAD2_MA1964.2 6 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 546 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 297 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 338 bp overlap

SMARCA4 4 datasets

ChIP 501-mel_SHCTR GSE61965.SMARCA4.501-mel_SHCTR 232 bp overlap

ChIP 501-mel_SHMITF GSE61965.SMARCA4.501-mel_SHMITF 185 bp overlap

ChIP 501-mel_SHMITF GSE61965.SMARCA4.501-mel_SHMITF 113 bp overlap

ChIP 501-mel_SHSOX10 GSE61965.SMARCA4.501-mel_SHSOX10 253 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 238 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 380 bp overlap

ChIP GM12878 ENCFF565AWY 201 bp overlap

ChIP GM12878 ENCFF878IIX 166 bp overlap

ChIP GM12878 ENCSR041XML.SRF.GM12878 322 bp overlap

ChIP H1 ENCFF036PEF 225 bp overlap

ChIP Ishikawa ENCFF992QXM 132 bp overlap

ChIP Ishikawa ENCSR000BTD.SRF.Ishikawa 313 bp overlap

ChIP WA01 ENCSR000BIV.SRF.WA01 145 bp overlap

STAT3 2 datasets

ChIP HCC1187 GSE152203.STAT3.HCC1187 63 bp overlap

ChIP HCC70_EtOH GSE85579.STAT3.HCC70_EtOH 59 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 183 bp overlap

VEZF1 3 datasets

Motif DE_48h DE_48h-VEZF1_MA1578.2 6 bp overlap

Motif DE_60h DE_60h-VEZF1_MA1578.2 6 bp overlap

Motif DE_72h DE_72h-VEZF1_MA1578.2 6 bp overlap

ZBTB7B 3 datasets

Motif DE_48h DE_48h-ZBTB7B_MA0694.2 10 bp overlap

Motif DE_60h DE_60h-ZBTB7B_MA0694.2 10 bp overlap

Motif DE_72h DE_72h-ZBTB7B_MA0694.2 10 bp overlap

ZNF22 1 dataset

ChIP HEK293 GSE76494.ZNF22.HEK293 194 bp overlap

ZNF281 3 datasets

Motif DE_48h DE_48h-ZNF281_MA1630.3 10 bp overlap

Motif DE_60h DE_60h-ZNF281_MA1630.3 10 bp overlap

Motif DE_72h DE_72h-ZNF281_MA1630.3 10 bp overlap

ZNF317 3 datasets

Motif DE_48h DE_48h-ZNF317_MA1593.2 8 bp overlap

Motif DE_60h DE_60h-ZNF317_MA1593.2 8 bp overlap

Motif DE_72h DE_72h-ZNF317_MA1593.2 8 bp overlap

ZNF335 1 dataset

ChIP HEK293 ENCSR328SUD.ZNF335.HEK293 259 bp overlap

ZNF362 2 datasets

ChIP HEK293 ENCSR715QNO.ZNF362.HEK293 304 bp overlap

ChIP HEK293 ENCSR715QNO.ZNF362.HEK293 295 bp overlap

ZNF384 2 datasets

ChIP HEK293T ENCFF019DZX 344 bp overlap

ChIP HEK293T ENCSR882ICT.ZNF384.HEK293T 286 bp overlap

ZNF76 3 datasets

Motif DE_48h DE_48h-ZNF76_MA1716.2 17 bp overlap

Motif DE_60h DE_60h-ZNF76_MA1716.2 17 bp overlap

Motif DE_72h DE_72h-ZNF76_MA1716.2 17 bp overlap

ZSCAN5C 2 datasets

ChIP HEK293 ENCFF343DTU 122 bp overlap

ChIP HEK293 ENCSR731AGO.ZSCAN5C.HEK293 57 bp overlap

Zic1::Zic2 1 dataset

Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap

Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap