The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for PGM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:63,316,605–63,317,949 | 276.1 kb | Distal (>10kb) Multiome | 584 | |
| chr1:63,321,880–63,324,736 | 270.9 kb | Distal (>10kb) Multiome | 684 | |
| chr1:63,326,144–63,327,160 | 267.0 kb | Distal (>10kb) Multiome | 213 | |
| chr1:63,327,552–63,328,285 | 265.6 kb | Distal (>10kb) Multiome | 328 | |
| chr1:63,329,526–63,330,869 | 262.7 kb | Distal (>10kb) Multiome | 128 | |
| chr1:63,367,059–63,368,178 | 225.8 kb | Distal (>10kb) Multiome | 818 | |
| chr1:63,522,907–63,524,033 | 70.0 kb | Distal (>10kb) Multiome | 1049 | |
| chr1:63,574,025–63,574,937 | 18.9 kb | Distal (>10kb) Multiome | 44 | |
| chr1:63,586,510–63,586,694 | 6.7 kb | Proximal (<10kb) | 2 | |
| chr1:63,590,562–63,590,743 | 2.7 kb | Proximal (<10kb) | 14 | |
| chr1:63,592,855–63,594,596 | 35 bp | At TSS Multiome | 842 | |
| chr1:63,613,061–63,613,814 | 19.9 kb | Distal (>10kb) Multiome | 42 | |
| chr1:63,773,619–63,776,510 | 182.8 kb | Distal (>10kb) Multiome | 734 | |
| chr1:63,783,027–63,783,543 | 189.8 kb | Distal (>10kb) Multiome | 65 | |
| chr1:63,789,946–63,790,789 | 197.0 kb | Distal (>10kb) Multiome | 116 | |
| chr1:63,843,664–63,844,806 | 250.7 kb | Distal (>10kb) Multiome | 106 | |
| chr1:64,450,715–64,451,728 | 857.9 kb | Distal (>10kb) Multiome HiCAR | 57 |
Genomic view of the PGM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.