Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of protein import into nucleus; positive regulation of protein localization to ciliary membrane; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be part of plasma membrane protein complex. Predicted to be active in ciliary membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EFCAB7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EFCAB7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EFCAB7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:63,316,605–63,317,949 | 206.2 kb | Distal (>10kb) Multiome | 584 | |
| chr1:63,321,880–63,324,736 | 201.0 kb | Distal (>10kb) Multiome | 684 | |
| chr1:63,326,144–63,327,160 | 197.1 kb | Distal (>10kb) Multiome | 213 | |
| chr1:63,327,552–63,328,285 | 195.7 kb | Distal (>10kb) Multiome | 328 | |
| chr1:63,329,526–63,330,869 | 192.9 kb | Distal (>10kb) Multiome | 128 | |
| chr1:63,367,059–63,368,178 | 155.9 kb | Distal (>10kb) Multiome | 818 | |
| chr1:63,522,907–63,524,033 | 135 bp | At TSS Multiome | 1049 | |
| chr1:63,574,025–63,574,937 | 51.0 kb | Distal (>10kb) Multiome | 44 | |
| chr1:63,592,855–63,594,596 | 69.9 kb | Distal (>10kb) Multiome | 842 | |
| chr1:63,613,061–63,613,814 | 89.8 kb | Distal (>10kb) Multiome | 42 | |
| chr1:63,773,619–63,776,510 | 252.7 kb | Distal (>10kb) Multiome | 734 | |
| chr1:63,783,027–63,783,543 | 259.7 kb | Distal (>10kb) Multiome | 65 | |
| chr1:63,789,946–63,790,789 | 266.9 kb | Distal (>10kb) Multiome | 116 |
Genomic view of the EFCAB7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.