This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for ITGB3BP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGB3BP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGB3BP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:63,316,605–63,317,949 | 205.9 kb | Distal (>10kb) Multiome | 584 | |
| chr1:63,321,880–63,324,736 | 200.7 kb | Distal (>10kb) Multiome | 684 | |
| chr1:63,326,144–63,327,160 | 196.8 kb | Distal (>10kb) Multiome | 213 | |
| chr1:63,327,552–63,328,285 | 195.4 kb | Distal (>10kb) Multiome | 328 | |
| chr1:63,329,526–63,330,869 | 192.5 kb | Distal (>10kb) Multiome | 128 | |
| chr1:63,367,059–63,368,178 | 155.6 kb | Distal (>10kb) Multiome | 818 | |
| chr1:63,522,907–63,524,033 | 180 bp | At TSS Multiome | 1049 | |
| chr1:63,574,025–63,574,937 | 51.3 kb | Distal (>10kb) Multiome | 44 | |
| chr1:63,592,855–63,594,596 | 70.2 kb | Distal (>10kb) Multiome | 842 | |
| chr1:63,613,061–63,613,814 | 90.1 kb | Distal (>10kb) Multiome | 42 | |
| chr1:63,773,619–63,776,510 | 253.0 kb | Distal (>10kb) Multiome | 734 | |
| chr1:63,783,027–63,783,543 | 260.0 kb | Distal (>10kb) Multiome | 65 | |
| chr1:63,789,946–63,790,789 | 267.2 kb | Distal (>10kb) Multiome | 116 |
Genomic view of the ITGB3BP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.