This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for ROR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ROR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ROR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:63,522,907–63,524,033 | 250.6 kb | Distal (>10kb) Multiome | 1049 | |
| chr1:63,574,025–63,574,937 | 199.5 kb | Distal (>10kb) Multiome | 44 | |
| chr1:63,592,855–63,594,596 | 180.6 kb | Distal (>10kb) Multiome | 842 | |
| chr1:63,613,061–63,613,814 | 160.7 kb | Distal (>10kb) Multiome | 42 | |
| chr1:63,772,778–63,772,908 | 1.1 kb | Proximal (<10kb) | 32 | |
| chr1:63,773,022–63,773,190 | 825 bp | At TSS | 79 | |
| chr1:63,773,619–63,776,510 | 2.2 kb | Proximal (<10kb) Multiome | 734 | |
| chr1:63,778,380–63,778,609 | 4.4 kb | Proximal (<10kb) | 47 | |
| chr1:63,780,712–63,781,023 | 6.7 kb | Proximal (<10kb) | 24 | |
| chr1:63,783,027–63,783,543 | 9.2 kb | Proximal (<10kb) Multiome | 65 | |
| chr1:63,789,946–63,790,789 | 16.4 kb | Distal (>10kb) Multiome | 116 | |
| chr1:63,843,664–63,844,806 | 70.1 kb | Distal (>10kb) Multiome | 106 |
Genomic view of the ROR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.