chr20 : 17,071,750 – 17,072,687
937 bp 58 TFs 1 linked gene
This 937 bp open chromatin element is linked to PCSK2 and is bound by 58 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
PCSK2 155.0 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr20:17,066,750 – 17,077,687
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
58 transcription factors
Source
Cell type
BRD2 1 dataset
ChIP HUVEC-C GSE60171.BRD2.HUVEC-C 195 bp overlap
BRD4 1 dataset
ChIP HUVEC-C GSE60171.BRD4.HUVEC-C 105 bp overlap
CTCF 2 datasets
Motif DE_60h DE_60h-CTCF_MA0139.2 15 bp overlap
ChIP endodermal cell ENCFF471YCZ 457 bp overlap
DMRTA2 2 datasets
Motif DE_60h DE_60h-DMRTA2_MA1478.2 6 bp overlap
Motif DE_72h DE_72h-DMRTA2_MA1478.2 6 bp overlap
EBF1 4 datasets
Motif DE_60h DE_60h-EBF1_MA0154.5 11 bp overlap
Motif DE_60h DE_60h-EBF1_MA0154.5 11 bp overlap
Motif DE_72h DE_72h-EBF1_MA0154.5 11 bp overlap
Motif DE_72h DE_72h-EBF1_MA0154.5 11 bp overlap
EBF3 2 datasets
Motif DE_60h DE_60h-EBF3_MA1637.2 9 bp overlap
Motif DE_72h DE_72h-EBF3_MA1637.2 9 bp overlap
EOMES 3 datasets
Motif DE_60h DE_60h-EOMES_MA0800.2 9 bp overlap
Motif DE_72h DE_72h-EOMES_MA0800.2 9 bp overlap
ChIP hESC GSE26097.EOMES.hESC 726 bp overlap
ERF::HOXB13 1 dataset
Motif DE_60h DE_60h-ERFHOXB13_MA1937.2 13 bp overlap
ESRRA 1 dataset
Motif DE_60h DE_60h-ESRRA_MA0592.4 9 bp overlap
ETV2::DRGX 1 dataset
Motif DE_60h DE_60h-ETV2DRGX_MA1940.2 12 bp overlap
ETV5::DRGX 1 dataset
Motif DE_60h DE_60h-ETV5DRGX_MA1944.2 12 bp overlap
Ebf4 4 datasets
Motif DE_60h DE_60h-Ebf4_MA2122.1 11 bp overlap
Motif DE_60h DE_60h-Ebf4_MA2122.1 11 bp overlap
Motif DE_72h DE_72h-Ebf4_MA2122.1 11 bp overlap
Motif DE_72h DE_72h-Ebf4_MA2122.1 11 bp overlap
FOXA2 3 datasets
ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 212 bp overlap
ChIP DE DE-FOXA2-1 937 bp overlap
ChIP DE DE-FOXA2-2 881 bp overlap
GATA4 2 datasets
ChIP DE DE-GATA4-1 937 bp overlap
ChIP DE DE-GATA4-2 937 bp overlap
GATA6 9 datasets
ChIP DE DE-GATA6-1 937 bp overlap
ChIP DE DE-GATA6-2 937 bp overlap
ChIP DE_D1 S09-DE-d1-GATA6-exp1 847 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 829 bp overlap
ChIP DE_D1 S41-DE-d1-GATA6-exp2 794 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 937 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 844 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 851 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 843 bp overlap
HMBOX1 2 datasets
Motif DE_60h DE_60h-HMBOX1_MA0895.2 7 bp overlap
Motif DE_72h DE_72h-HMBOX1_MA0895.2 7 bp overlap
Isl1 2 datasets
Motif DE_60h DE_60h-Isl1_MA1608.2 7 bp overlap
Motif DE_72h DE_72h-Isl1_MA1608.2 7 bp overlap
JUN 1 dataset
ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 288 bp overlap
MEIS1 2 datasets
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
MEIS2 2 datasets
Motif DE_60h DE_60h-MEIS2_MA0774.1 8 bp overlap
Motif DE_72h DE_72h-MEIS2_MA0774.1 8 bp overlap
MEIS3 2 datasets
Motif DE_60h DE_60h-MEIS3_MA0775.2 7 bp overlap
Motif DE_72h DE_72h-MEIS3_MA0775.2 7 bp overlap
MGA 2 datasets
Motif DE_60h DE_60h-MGA_MA0801.1 8 bp overlap
Motif DE_72h DE_72h-MGA_MA0801.1 8 bp overlap
MZF1 3 datasets
Motif DE_48h DE_48h-MZF1_MA0056.3 8 bp overlap
Motif DE_60h DE_60h-MZF1_MA0056.3 8 bp overlap
Motif DE_72h DE_72h-MZF1_MA0056.3 8 bp overlap
NR5A1 1 dataset
Motif DE_60h DE_60h-NR5A1_MA1540.3 12 bp overlap
Nr5A2 1 dataset
Motif DE_60h DE_60h-Nr5A2_MA0505.3 9 bp overlap
RARA 1 dataset
Motif DE_60h DE_60h-RARA_MA0730.1 17 bp overlap
RARA::RXRG 1 dataset
Motif DE_60h DE_60h-RARARXRG_MA1149.2 17 bp overlap
RORA 1 dataset
Motif DE_60h DE_60h-RORA_MA0071.1 10 bp overlap
RXRG 1 dataset
Motif DE_60h DE_60h-RXRG_MA1556.1 14 bp overlap
Rarb 1 dataset
Motif DE_60h DE_60h-Rarb_MA0858.1 17 bp overlap
SMAD2 1 dataset
ChIP endoderm GSE29422.SMAD2.endoderm 258 bp overlap
SMAD2-3 3 datasets
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 887 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 736 bp overlap
ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 523 bp overlap
SMAD2_3 4 datasets
ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 460 bp overlap
ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 437 bp overlap
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 736 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 835 bp overlap
SMAD3 1 dataset
ChIP PC-3_hypoxia GSE106305.SMAD3.PC-3_hypoxia 149 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 149 bp overlap
SOX10 2 datasets
Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap
Motif DE_72h DE_72h-SOX10_MA0442.3 6 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 652 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 834 bp overlap
SOX18 1 dataset
Motif DE_60h DE_60h-SOX18_MA1563.2 8 bp overlap
SOX4 1 dataset
Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap
SOX8 1 dataset
Motif DE_60h DE_60h-SOX8_MA0868.3 7 bp overlap
SOX9 1 dataset
Motif DE_60h DE_60h-SOX9_MA0077.2 8 bp overlap
SRY 1 dataset
Motif DE_60h DE_60h-SRY_MA0084.2 7 bp overlap
Sox17 1 dataset
Motif DE_60h DE_60h-Sox17_MA0078.3 10 bp overlap
Sox5 1 dataset
Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap
Sox6 1 dataset
Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap
Sox7 1 dataset
Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap
TBR1 2 datasets
Motif DE_60h DE_60h-TBR1_MA0802.2 9 bp overlap
Motif DE_72h DE_72h-TBR1_MA0802.2 9 bp overlap
TBX1 2 datasets
Motif DE_60h DE_60h-TBX1_MA0805.1 8 bp overlap
Motif DE_72h DE_72h-TBX1_MA0805.1 8 bp overlap
TBX15 2 datasets
Motif DE_60h DE_60h-TBX15_MA0803.1 8 bp overlap
Motif DE_72h DE_72h-TBX15_MA0803.1 8 bp overlap
TBX20 2 datasets
Motif DE_60h DE_60h-TBX20_MA0689.1 11 bp overlap
Motif DE_72h DE_72h-TBX20_MA0689.1 11 bp overlap
TBX21 2 datasets
Motif DE_60h DE_60h-TBX21_MA0690.3 10 bp overlap
Motif DE_72h DE_72h-TBX21_MA0690.3 10 bp overlap
TBX4 2 datasets
Motif DE_60h DE_60h-TBX4_MA0806.1 8 bp overlap
Motif DE_72h DE_72h-TBX4_MA0806.1 8 bp overlap
VENTX 2 datasets
Motif DE_60h DE_60h-VENTX_MA0724.1 9 bp overlap
Motif DE_72h DE_72h-VENTX_MA0724.1 9 bp overlap
ZKSCAN3 3 datasets
Motif DE_48h DE_48h-ZKSCAN3_MA1973.2 14 bp overlap
Motif DE_60h DE_60h-ZKSCAN3_MA1973.2 14 bp overlap
Motif DE_72h DE_72h-ZKSCAN3_MA1973.2 14 bp overlap
ZNF675 1 dataset
Motif DE_60h DE_60h-ZNF675_MA1714.2 19 bp overlap
ZSCAN21 2 datasets
Motif DE_60h DE_60h-ZSCAN21_MA2336.1 7 bp overlap
Motif DE_72h DE_72h-ZSCAN21_MA2336.1 7 bp overlap
Zfx 1 dataset
Motif DE_60h DE_60h-Zfx_MA0146.3 10 bp overlap
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