chr6 : 21,259,520 – 21,260,167

647 bp 75 TFs 1 linked gene

This 647 bp open chromatin element is linked to SOX4 and is bound by 75 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
SOX4		333.9 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

75 transcription factors

ASCL1 1 dataset

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 224 bp overlap

Ascl2 1 dataset

Motif DE_48h DE_48h-Ascl2_MA0816.1 10 bp overlap

Atoh1 1 dataset

Motif DE_48h DE_48h-Atoh1_MA1467.3 7 bp overlap

BHLHE22 1 dataset

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

BRD4 1 dataset

ChIP MV4-11-B_BI00894999_100nM_4h GSE101821.BRD4.MV4-11-B_BI00894999_100nM_4h 289 bp overlap

Bhlha15 1 dataset

Motif DE_48h DE_48h-Bhlha15_MA1472.3 8 bp overlap

CTCF 1 dataset

ChIP HUDEP-2_30min GSE104676.CTCF.HUDEP-2_30min 67 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF364PUR 251 bp overlap

ChIP BLaER1 ENCFF844FIP 81 bp overlap

Crx 1 dataset

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 485 bp overlap

ERF::FOXO1 1 dataset

Motif DE_48h DE_48h-ERFFOXO1_MA1936.2 12 bp overlap

FIGLA 1 dataset

Motif DE_48h DE_48h-FIGLA_MA0820.2 6 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_48h DE_48h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 582 bp overlap

ChIP DE DE-FOXA2-2 418 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_48h DE_48h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_48h DE_48h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 539 bp overlap

ChIP DE DE-GATA4-2 542 bp overlap

GATA6 4 datasets

ChIP DE DE-GATA6-1 545 bp overlap

ChIP DE DE-GATA6-2 607 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 404 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 513 bp overlap

GSC 1 dataset

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

GSC2 1 dataset

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

HAND2 1 dataset

Motif DE_48h DE_48h-HAND2_MA1638.2 6 bp overlap

HCFC1R1 1 dataset

ChIP cartilage GSE100311.HCFC1R1.cartilage 51 bp overlap

IKZF1 1 dataset

ChIP GM12878 ENCFF753XDO 342 bp overlap

LMO1 1 dataset

ChIP Jurkat GSE94391.LMO1.Jurkat 356 bp overlap

MEF2A 1 dataset

Motif DE_48h DE_48h-MEF2A_MA0052.5 10 bp overlap

MEF2B 1 dataset

ChIP KARPAS422 GSE69558.MEF2B.KARPAS422 172 bp overlap

MGA 1 dataset

Motif DE_48h DE_48h-MGA_MA0801.1 8 bp overlap

MSC 1 dataset

Motif DE_48h DE_48h-MSC_MA0665.1 10 bp overlap

MYB 2 datasets

ChIP Jurkat GSE59657.MYB.Jurkat 415 bp overlap

ChIP Loucy GSE94000.MYB.Loucy 319 bp overlap

MYF5 1 dataset

Motif DE_48h DE_48h-MYF5_MA1641.2 8 bp overlap

MYOD1 3 datasets

Motif DE_48h DE_48h-MYOD1_MA0499.3 9 bp overlap

ChIP RD_shSNAI2 GSE137168.MYOD1.RD_shSNAI2 242 bp overlap

NEUROD1 4 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 343 bp overlap

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 325 bp overlap

Motif DE_48h DE_48h-NEUROD1_MA1109.2 8 bp overlap

NEUROG2 3 datasets

Motif DE_48h DE_48h-NEUROG2_MA1642.2 7 bp overlap

ChIP MRC-5_NFD_05DPT GSE75910.NEUROG2.MRC-5_NFD_05DPT 140 bp overlap

ChIP MRC-5_NFD_1DPT GSE75910.NEUROG2.MRC-5_NFD_1DPT 401 bp overlap

NFYA 1 dataset

Motif DE_48h DE_48h-NFYA_MA0060.4 8 bp overlap

NR2F2 1 dataset

ChIP MCF-7_Veh GSE132432.NR2F2.MCF-7_Veh 91 bp overlap

Neurod2 3 datasets

Motif DE_48h DE_48h-Neurod2_MA0668.3 8 bp overlap

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

OTX1 1 dataset

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

OTX2 1 dataset

Motif DE_48h DE_48h-OTX2_MA0712.3 7 bp overlap

Olig2 1 dataset

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

PITX1 1 dataset

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap

PITX3 1 dataset

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Ptf1A 2 datasets

Motif DE_48h DE_48h-Ptf1A_MA1619.2 8 bp overlap

Motif DE_48h DE_48h-Ptf1A_MA1620.2 8 bp overlap

RELB 1 dataset

ChIP GM12878 ENCSR387QUV.RELB.GM12878 73 bp overlap

RHOXF1 1 dataset

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

RUNX1 2 datasets

ChIP MV4-11 GSE79899.RUNX1.MV4-11 177 bp overlap

ChIP NALM-6 GSE126300.RUNX1.NALM-6 435 bp overlap

Rhox11 1 dataset

Motif DE_48h DE_48h-Rhox11_MA0629.2 9 bp overlap

SCRT1 1 dataset

Motif DE_48h DE_48h-SCRT1_MA0743.3 10 bp overlap

SCRT2 1 dataset

Motif DE_48h DE_48h-SCRT2_MA0744.3 10 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 198 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 573 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 353 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 552 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 556 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 224 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 224 bp overlap

SNAI2 1 dataset

Motif DE_48h DE_48h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif DE_48h DE_48h-SNAI3_MA1559.2 9 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 265 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 441 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 422 bp overlap

TAL1::TCF3 1 dataset

Motif DE_48h DE_48h-TAL1TCF3_MA0091.2 10 bp overlap

TBX21 1 dataset

ChIP GM12878 ENCSR739IHN.TBX21.GM12878 261 bp overlap

TCF3 2 datasets

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 478 bp overlap

ChIP NPC GSE154479.TCF3.NPC 230 bp overlap

TCF4 3 datasets

ChIP CAL-1 GSE76147.TCF4.CAL-1 245 bp overlap

Motif DE_48h DE_48h-TCF4_MA0830.3 8 bp overlap

ChIP GEN2-2 GSE76147.TCF4.GEN2-2 463 bp overlap

TFAP4 1 dataset

Motif DE_48h DE_48h-TFAP4_MA0691.1 10 bp overlap

Tbx6 1 dataset

Motif DE_48h DE_48h-Tbx6_MA1567.3 9 bp overlap

Tcf12 1 dataset

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Tcf21 1 dataset

Motif DE_48h DE_48h-Tcf21_MA0832.2 10 bp overlap

Twist2 1 dataset

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

ZBTB18 1 dataset

Motif DE_48h DE_48h-ZBTB18_MA0698.2 11 bp overlap

ZEB1 1 dataset

Motif DE_48h DE_48h-ZEB1_MA0103.4 6 bp overlap

ZIM3 1 dataset

Motif DE_48h DE_48h-ZIM3_MA1709.2 11 bp overlap

ZNF16 1 dataset

Motif DE_48h DE_48h-ZNF16_MA1654.2 21 bp overlap

ZNF684 1 dataset

Motif DE_48h DE_48h-ZNF684_MA1600.2 14 bp overlap

Zfp809 1 dataset

Motif DE_48h DE_48h-Zfp809_MA2125.1 9 bp overlap