chr20 : 17,138,139 – 17,138,728
589 bp 77 TFs 1 linked gene
This 589 bp open chromatin element is linked to PCSK2 and is bound by 77 transcription factors.
Linked Genes
1 gene
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
PCSK2 88.7 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr20:17,133,139 – 17,143,728
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
77 transcription factors
Source
Cell type
ASCL1 2 datasets
Motif DE_60h DE_60h-ASCL1_MA1631.2 9 bp overlap
Motif DE_72h DE_72h-ASCL1_MA1631.2 9 bp overlap
Ahr::Arnt 1 dataset
Motif DE_60h DE_60h-AhrArnt_MA0006.2 5 bp overlap
Arid3a 3 datasets
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap
BCL6 3 datasets
Motif DE_48h DE_48h-BCL6_MA0463.3 13 bp overlap
Motif DE_60h DE_60h-BCL6_MA0463.3 13 bp overlap
Motif DE_72h DE_72h-BCL6_MA0463.3 13 bp overlap
BCL6B 3 datasets
Motif DE_48h DE_48h-BCL6B_MA0731.1 17 bp overlap
Motif DE_60h DE_60h-BCL6B_MA0731.1 17 bp overlap
Motif DE_72h DE_72h-BCL6B_MA0731.1 17 bp overlap
BRD4 3 datasets
ChIP HEK293_Ctrl GSE129407.BRD4.HEK293_Ctrl 198 bp overlap
ChIP HEK293_sgNT GSE129407.BRD4.HEK293_sgNT 232 bp overlap
ChIP IMR-90_SENES GSE74238.BRD4.IMR-90_SENES 152 bp overlap
Bach1::Mafk 3 datasets
Motif DE_48h DE_48h-Bach1Mafk_MA0591.2 12 bp overlap
Motif DE_60h DE_60h-Bach1Mafk_MA0591.2 12 bp overlap
Motif DE_72h DE_72h-Bach1Mafk_MA0591.2 12 bp overlap
Cebpa 1 dataset
ChIP BLaER1 ENCFF335XTP 290 bp overlap
EED 1 dataset
ChIP ProEs GSE59087.EED.ProEs 131 bp overlap
ERF::NHLH1 3 datasets
Motif DE_48h DE_48h-ERFNHLH1_MA1938.2 16 bp overlap
Motif DE_60h DE_60h-ERFNHLH1_MA1938.2 16 bp overlap
Motif DE_72h DE_72h-ERFNHLH1_MA1938.2 16 bp overlap
ESR1 1 dataset
ChIP MCF-7_E2 GSE14664.ESR1.MCF-7_E2 94 bp overlap
ESRRG 1 dataset
ChIP cardiomyocyte GSE113760.ESRRG.cardiomyocyte 299 bp overlap
ETS1 1 dataset
ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 127 bp overlap
FIGLA 2 datasets
Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap
Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap
FOS 3 datasets
Motif DE_48h DE_48h-FOS_MA0476.2 8 bp overlap
Motif DE_60h DE_60h-FOS_MA0476.2 8 bp overlap
Motif DE_72h DE_72h-FOS_MA0476.2 8 bp overlap
FOXA2 2 datasets
ChIP DE DE-FOXA2-1 442 bp overlap
ChIP DE DE-FOXA2-2 391 bp overlap
FOXN3 2 datasets
Motif DE_48h DE_48h-FOXN3_MA1489.1 8 bp overlap
Motif DE_60h DE_60h-FOXN3_MA1489.1 8 bp overlap
FOXP2 2 datasets
Motif DE_48h DE_48h-FOXP2_MA0593.2 9 bp overlap
Motif DE_60h DE_60h-FOXP2_MA0593.2 9 bp overlap
GATA4 7 datasets
ChIP DE DE-GATA4-1 481 bp overlap
ChIP DE DE-GATA4-2 468 bp overlap
Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap
Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap
Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap
ChIP foregut GSE117136.GATA4.foregut 398 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 372 bp overlap
GATA6 8 datasets
ChIP DE DE-GATA6-1 444 bp overlap
ChIP DE DE-GATA6-2 414 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 333 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 278 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 394 bp overlap
ChIP foregut GSE117136.GATA6.foregut 394 bp overlap
ChIP foregut_KO GSE117136.GATA6.foregut_KO 302 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 397 bp overlap
GRHL2 1 dataset
Motif DE_60h DE_60h-GRHL2_MA1105.3 8 bp overlap
HDAC3 1 dataset
ChIP RH4_DMSO-6H GSE116344.HDAC3.RH4_DMSO-6H 504 bp overlap
HNF1A 3 datasets
Motif DE_48h DE_48h-HNF1A_MA0046.3 13 bp overlap
Motif DE_60h DE_60h-HNF1A_MA0046.3 13 bp overlap
Motif DE_72h DE_72h-HNF1A_MA0046.3 13 bp overlap
Jun 3 datasets
Motif DE_48h DE_48h-Jun_MA0489.3 8 bp overlap
Motif DE_60h DE_60h-Jun_MA0489.3 8 bp overlap
Motif DE_72h DE_72h-Jun_MA0489.3 8 bp overlap
KLF1 1 dataset
Motif DE_60h DE_60h-KLF1_MA0493.3 8 bp overlap
KLF10 1 dataset
Motif DE_60h DE_60h-KLF10_MA1511.2 9 bp overlap
KLF12 1 dataset
Motif DE_60h DE_60h-KLF12_MA0742.2 9 bp overlap
KLF2 1 dataset
Motif DE_60h DE_60h-KLF2_MA1515.2 8 bp overlap
KLF6 1 dataset
Motif DE_60h DE_60h-KLF6_MA1517.2 9 bp overlap
KLF7 1 dataset
Motif DE_60h DE_60h-KLF7_MA1959.2 8 bp overlap
LIN54 1 dataset
Motif DE_60h DE_60h-LIN54_MA0619.2 7 bp overlap
MAF 3 datasets
Motif DE_48h DE_48h-MAF_MA1520.2 13 bp overlap
Motif DE_60h DE_60h-MAF_MA1520.2 13 bp overlap
Motif DE_72h DE_72h-MAF_MA1520.2 13 bp overlap
MAFA 3 datasets
Motif DE_48h DE_48h-MAFA_MA1521.2 13 bp overlap
Motif DE_60h DE_60h-MAFA_MA1521.2 13 bp overlap
Motif DE_72h DE_72h-MAFA_MA1521.2 13 bp overlap
MAFF 3 datasets
Motif DE_48h DE_48h-MAFF_MA0495.4 11 bp overlap
Motif DE_60h DE_60h-MAFF_MA0495.4 11 bp overlap
Motif DE_72h DE_72h-MAFF_MA0495.4 11 bp overlap
MAFG::NFE2L1 3 datasets
Motif DE_48h DE_48h-MAFGNFE2L1_MA0089.3 11 bp overlap
Motif DE_60h DE_60h-MAFGNFE2L1_MA0089.3 11 bp overlap
Motif DE_72h DE_72h-MAFGNFE2L1_MA0089.3 11 bp overlap
MAFK 6 datasets
Motif DE_48h DE_48h-MAFK_MA0496.4 10 bp overlap
Motif DE_48h DE_48h-MAFK_MA0496.4 10 bp overlap
Motif DE_60h DE_60h-MAFK_MA0496.4 10 bp overlap
Motif DE_60h DE_60h-MAFK_MA0496.4 10 bp overlap
Motif DE_72h DE_72h-MAFK_MA0496.4 10 bp overlap
Motif DE_72h DE_72h-MAFK_MA0496.4 10 bp overlap
MEIS1 3 datasets
Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap
Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap
Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap
MYF6 3 datasets
Motif DE_48h DE_48h-MYF6_MA0667.1 10 bp overlap
Motif DE_60h DE_60h-MYF6_MA0667.1 10 bp overlap
Motif DE_72h DE_72h-MYF6_MA0667.1 10 bp overlap
MYOD1 1 dataset
ChIP RH30_DMSO GSE85169.MYOD1.RH30_DMSO 205 bp overlap
MYOG 1 dataset
ChIP RH30_DMSO GSE85169.MYOG.RH30_DMSO 359 bp overlap
Mafg 3 datasets
Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap
Motif DE_60h DE_60h-Mafg_MA0659.4 12 bp overlap
Motif DE_72h DE_72h-Mafg_MA0659.4 12 bp overlap
Mecom 3 datasets
Motif DE_48h DE_48h-Mecom_MA0029.2 11 bp overlap
Motif DE_60h DE_60h-Mecom_MA0029.2 11 bp overlap
Motif DE_72h DE_72h-Mecom_MA0029.2 11 bp overlap
NCOA2 1 dataset
ChIP MCF-7_E2 ERP000901.NCOA2.MCF-7_E2 118 bp overlap
NKX2-5 1 dataset
ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 386 bp overlap
NR2F2 1 dataset
ChIP hiPSC GSE81585.NR2F2.hiPSC 231 bp overlap
NR3C1 5 datasets
ChIP BEAS-2B_DEX GSE125623.NR3C1.BEAS-2B_DEX 300 bp overlap
ChIP U2OS_GLUCC ERP007081.NR3C1.U2OS_GLUCC 126 bp overlap
ChIP U2OS_SHHIC5 GSE65847.NR3C1.U2OS_SHHIC5 472 bp overlap
ChIP U2OS_SHNS GSE65847.NR3C1.U2OS_SHNS 369 bp overlap
ChIP U2OS_siHic5siNS GSE109383.NR3C1.U2OS_siHic5siNS 314 bp overlap
PAX3-FOXO1 1 dataset
ChIP RH3 GSE83726.PAX3-FOXO1.RH3 216 bp overlap
Runx1 3 datasets
Motif DE_48h DE_48h-Runx1_MA0002.3 9 bp overlap
Motif DE_60h DE_60h-Runx1_MA0002.3 9 bp overlap
Motif DE_72h DE_72h-Runx1_MA0002.3 9 bp overlap
SMAD2 4 datasets
Motif DE_48h DE_48h-SMAD2_MA1964.2 6 bp overlap
Motif DE_60h DE_60h-SMAD2_MA1964.2 6 bp overlap
Motif DE_72h DE_72h-SMAD2_MA1964.2 6 bp overlap
ChIP endoderm GSE29422.SMAD2.endoderm 157 bp overlap
SMAD2-3 1 dataset
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 575 bp overlap
SMAD2_3 2 datasets
ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 232 bp overlap
ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 282 bp overlap
SMAD4 1 dataset
ChIP endoderm GSE29422.SMAD4.endoderm 161 bp overlap
SNAI1 2 datasets
Motif DE_60h DE_60h-SNAI1_MA1558.2 7 bp overlap
Motif DE_72h DE_72h-SNAI1_MA1558.2 7 bp overlap
SNAI2 2 datasets
ChIP SMS-CTR_T48 GSE137168.SNAI2.SMS-CTR_T48 251 bp overlap
ChIP SMS-CTR_shSNAI2 GSE137168.SNAI2.SMS-CTR_shSNAI2 197 bp overlap
SNAI3 2 datasets
Motif DE_60h DE_60h-SNAI3_MA1559.2 9 bp overlap
Motif DE_72h DE_72h-SNAI3_MA1559.2 9 bp overlap
SOX10 2 datasets
Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap
Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap
SOX17 1 dataset
ChIP DE_D2 DED2-SOX17_Batch_II 349 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 428 bp overlap
SOX4 2 datasets
Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap
Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap
Sox11 2 datasets
Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap
Motif DE_60h DE_60h-Sox11_MA0869.3 8 bp overlap
Sox6 2 datasets
Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap
Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap
TBX18 2 datasets
Motif DE_60h DE_60h-TBX18_MA1565.2 9 bp overlap
Motif DE_72h DE_72h-TBX18_MA1565.2 9 bp overlap
TBX5 1 dataset
ChIP hiPSC GSE81585.TBX5.hiPSC 373 bp overlap
TCF12 2 datasets
Motif DE_60h DE_60h-TCF12_MA1648.2 7 bp overlap
Motif DE_72h DE_72h-TCF12_MA1648.2 7 bp overlap
TCF3 2 datasets
Motif DE_60h DE_60h-TCF3_MA0522.4 7 bp overlap
Motif DE_72h DE_72h-TCF3_MA0522.4 7 bp overlap
TCF4 2 datasets
Motif DE_60h DE_60h-TCF4_MA0830.3 8 bp overlap
Motif DE_72h DE_72h-TCF4_MA0830.3 8 bp overlap
THAP1 3 datasets
Motif DE_48h DE_48h-THAP1_MA0597.3 8 bp overlap
Motif DE_60h DE_60h-THAP1_MA0597.3 8 bp overlap
Motif DE_72h DE_72h-THAP1_MA0597.3 8 bp overlap
THRB 3 datasets
Motif DE_48h DE_48h-THRB_MA1575.2 17 bp overlap
Motif DE_60h DE_60h-THRB_MA1575.2 17 bp overlap
Motif DE_72h DE_72h-THRB_MA1575.2 17 bp overlap
ZBTB6 1 dataset
Motif DE_60h DE_60h-ZBTB6_MA1581.2 9 bp overlap
ZEB1 2 datasets
Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap
Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap
ZNF16 3 datasets
Motif DE_48h DE_48h-ZNF16_MA1654.2 21 bp overlap
Motif DE_60h DE_60h-ZNF16_MA1654.2 21 bp overlap
Motif DE_72h DE_72h-ZNF16_MA1654.2 21 bp overlap
ZNF214 3 datasets
Motif DE_48h DE_48h-ZNF214_MA1975.2 13 bp overlap
Motif DE_60h DE_60h-ZNF214_MA1975.2 13 bp overlap
Motif DE_72h DE_72h-ZNF214_MA1975.2 13 bp overlap
ZNF341 3 datasets
Motif DE_48h DE_48h-ZNF341_MA1655.2 8 bp overlap
Motif DE_60h DE_60h-ZNF341_MA1655.2 8 bp overlap
Motif DE_72h DE_72h-ZNF341_MA1655.2 8 bp overlap
ZNF460 3 datasets
Motif DE_48h DE_48h-ZNF460_MA1596.1 16 bp overlap
Motif DE_60h DE_60h-ZNF460_MA1596.1 16 bp overlap
Motif DE_72h DE_72h-ZNF460_MA1596.1 16 bp overlap
ZNF547 3 datasets
Motif DE_48h DE_48h-ZNF547_MA2334.1 13 bp overlap
Motif DE_60h DE_60h-ZNF547_MA2334.1 13 bp overlap
Motif DE_72h DE_72h-ZNF547_MA2334.1 13 bp overlap
ZNF549 3 datasets
Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap
Motif DE_60h DE_60h-ZNF549_MA1728.2 8 bp overlap
Motif DE_72h DE_72h-ZNF549_MA1728.2 8 bp overlap
ZSCAN21 1 dataset
Motif DE_60h DE_60h-ZSCAN21_MA2336.1 7 bp overlap
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