chr18 : 57,595,355 – 57,595,786

431 bp 64 TFs 1 linked gene

This 431 bp open chromatin element is linked to FECH and is bound by 64 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
FECH		8.6 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

64 transcription factors

ARID2 1 dataset

ChIP Aska-SS GSE108025.ARID2.Aska-SS 431 bp overlap

Arid3a 1 dataset

Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF335XTP 251 bp overlap

Crx 2 datasets

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

DPRX 2 datasets

Motif DE_60h DE_60h-DPRX_MA1480.2 9 bp overlap

Motif DE_72h DE_72h-DPRX_MA1480.2 9 bp overlap

E2F6 1 dataset

Motif DE_72h DE_72h-E2F6_MA0471.3 8 bp overlap

E2F7 1 dataset

Motif DE_72h DE_72h-E2F7_MA0758.1 14 bp overlap

E2F8 1 dataset

ChIP K-562 ENCSR953DVM.E2F8.K-562 233 bp overlap

ERF::FOXI1 1 dataset

Motif DE_72h DE_72h-ERFFOXI1_MA1935.2 10 bp overlap

ETV2 1 dataset

Motif DE_72h DE_72h-ETV2_MA0762.2 9 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_72h DE_72h-ETV2FOXI1_MA1942.2 11 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_72h DE_72h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 292 bp overlap

ChIP DE DE-FOXA2-2 292 bp overlap

FOXO1::ELF1 1 dataset

Motif DE_72h DE_72h-FOXO1ELF1_MA1953.2 13 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_72h DE_72h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_72h DE_72h-FOXO1FLI1_MA1956.2 13 bp overlap

FOXP2 1 dataset

Motif DE_72h DE_72h-FOXP2_MA0593.2 9 bp overlap

GATA4 3 datasets

ChIP DE DE-GATA4-1 395 bp overlap

ChIP DE DE-GATA4-2 431 bp overlap

ChIP foregut GSE117136.GATA4.foregut 378 bp overlap

GATA6 5 datasets

ChIP DE DE-GATA6-1 422 bp overlap

ChIP DE DE-GATA6-2 431 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 397 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 403 bp overlap

ChIP foregut GSE117136.GATA6.foregut 348 bp overlap

GSC 2 datasets

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

GSC2 2 datasets

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

Hmga1 1 dataset

Motif DE_72h DE_72h-Hmga1_MA2124.1 8 bp overlap

IKZF1 1 dataset

Motif DE_72h DE_72h-IKZF1_MA1508.2 8 bp overlap

MXI1 2 datasets

Motif DE_60h DE_60h-MXI1_MA1108.3 6 bp overlap

Motif DE_72h DE_72h-MXI1_MA1108.3 6 bp overlap

MYB 1 dataset

ChIP Jurkat GSE59657.MYB.Jurkat 194 bp overlap

NR1I2 1 dataset

Motif DE_72h DE_72h-NR1I2_MA1533.2 15 bp overlap

ONECUT1 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.ONECUT1.pancreatic-progenitor_PP1 57 bp overlap

OTX1 2 datasets

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

PAF1 1 dataset

ChIP HCT-116_ab20662 GSE97527.PAF1.HCT-116_ab20662 431 bp overlap

PITX1 2 datasets

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX3 2 datasets

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

RARA 1 dataset

Motif DE_72h DE_72h-RARA_MA0729.1 18 bp overlap

RELA 1 dataset

Motif DE_72h DE_72h-RELA_MA0107.1 10 bp overlap

RHOXF1 2 datasets

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

SIN3A 1 dataset

ChIP HUVEC-C GSE103245.SIN3A.HUVEC-C 152 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 431 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 340 bp overlap

SMAD3 1 dataset

ChIP SUM159PT GSE130364.SMAD3.SUM159PT 149 bp overlap

SOX13 1 dataset

Motif DE_72h DE_72h-SOX13_MA1120.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 205 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 308 bp overlap

SOX2 1 dataset

Motif DE_72h DE_72h-SOX2_MA0143.5 7 bp overlap

SP5 2 datasets

Motif DE_60h DE_60h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

SUPT5H 1 dataset

ChIP HCT-116_pThr806 GSE138548.SUPT5H.HCT-116_pThr806 395 bp overlap

Sox1 2 datasets

Motif DE_60h DE_60h-Sox1_MA0870.1 15 bp overlap

Motif DE_72h DE_72h-Sox1_MA0870.1 15 bp overlap

Sox3 1 dataset

Motif DE_72h DE_72h-Sox3_MA0514.3 7 bp overlap

Sox5 1 dataset

Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap

Sox6 1 dataset

Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap

Spi1 1 dataset

Motif DE_72h DE_72h-Spi1_MA0080.7 13 bp overlap

Stat2 1 dataset

Motif DE_72h DE_72h-Stat2_MA1623.2 10 bp overlap

TFAP4::FLI1 1 dataset

Motif DE_72h DE_72h-TFAP4FLI1_MA1967.2 14 bp overlap

TP73 2 datasets

Motif DE_60h DE_60h-TP73_MA0861.2 16 bp overlap

Motif DE_72h DE_72h-TP73_MA0861.2 16 bp overlap

ZBTB32 1 dataset

Motif DE_72h DE_72h-ZBTB32_MA1580.1 10 bp overlap

ZIM3 1 dataset

Motif DE_72h DE_72h-ZIM3_MA1709.2 11 bp overlap

ZNF22 1 dataset

ChIP HEK293 GSE76494.ZNF22.HEK293 270 bp overlap

ZNF282 1 dataset

Motif DE_72h DE_72h-ZNF282_MA1154.2 15 bp overlap

ZNF317 1 dataset

Motif DE_72h DE_72h-ZNF317_MA1593.2 8 bp overlap

ZNF354C 2 datasets

Motif DE_60h DE_60h-ZNF354C_MA0130.1 6 bp overlap

Motif DE_72h DE_72h-ZNF354C_MA0130.1 6 bp overlap

ZNF362 2 datasets

ChIP HEK293 ENCFF436CGE 110 bp overlap

ChIP HEK293 ENCSR715QNO.ZNF362.HEK293 271 bp overlap

ZNF547 2 datasets

Motif DE_60h DE_60h-ZNF547_MA2334.1 13 bp overlap

Motif DE_72h DE_72h-ZNF547_MA2334.1 13 bp overlap

ZNF675 1 dataset

Motif DE_72h DE_72h-ZNF675_MA1714.2 19 bp overlap

ZNF677 1 dataset

Motif DE_72h DE_72h-ZNF677_MA2101.1 12 bp overlap

ZNF766 1 dataset

Motif DE_72h DE_72h-ZNF766_MA2098.1 9 bp overlap

ZXDB 1 dataset

ChIP HEK293 ENCSR559IOZ.ZXDB.HEK293 161 bp overlap