DE-12

Supermodule 146 genes

Immune response and cell surface signaling

Module DE-12 contains 152 genes including KIT, LGALS1, RIPK1, PDPN, and BST2, with enrichment in immune response and cell surface receptor signaling. Knockdown of ZNF644 activates this module. Knockdown of SETDB1, DNMT1, ADNP2, CHAMP1, and RCOR2 represses this module.

Notable genes: KIT LGALS1 RIPK1 PDPN BST2 CHRM3 SORD PVR Top TFs: SETDB1 DNMT1 ADNP2 CHAMP1 RCOR2

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (4)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-12.1	43	KIT PDPN PVR CDH3 DAB2
DE-12.2	33	CHRM3 STS PDK1 SLCO1A2 TNNT1
DE-12.3	25	TRIM24 TUSC3 DLEU1 ATF7IP CPLANE1
DE-12.4	13	BST2 FEZ1 COL6A2 RMST CLTB

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).