Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CLTB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLTB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLTB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,172,154–176,172,641 | 244.0 kb | Distal (>10kb) Multiome | 15 | |
| chr5:176,183,360–176,184,067 | 232.7 kb | Distal (>10kb) Multiome | 165 | |
| chr5:176,361,095–176,362,133 | 54.8 kb | Distal (>10kb) Multiome | 877 | |
| chr5:176,365,184–176,366,532 | 51.0 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,388,019–176,389,614 | 27.6 kb | Distal (>10kb) Multiome | 1052 | |
| chr5:176,415,859–176,416,971 | 86 bp | At TSS Multiome | 827 | |
| chr5:176,418,347–176,418,635 | 1.8 kb | Proximal (<10kb) | 97 | |
| chr5:176,420,871–176,421,252 | 4.3 kb | Proximal (<10kb) | 58 | |
| chr5:176,441,967–176,442,454 | 25.7 kb | Distal (>10kb) Multiome | 166 | |
| chr5:176,447,162–176,449,016 | 31.7 kb | Distal (>10kb) Multiome | 859 | |
| chr5:176,536,385–176,538,671 | 121.4 kb | Distal (>10kb) Multiome HiCAR | 1006 | |
| chr5:176,541,333–176,544,229 | 125.2 kb | Distal (>10kb) Multiome HiCAR | 733 | |
| chr5:176,596,638–176,597,570 | 180.5 kb | Distal (>10kb) Multiome | 234 | |
| chr5:176,609,466–176,610,727 | 193.5 kb | Distal (>10kb) Multiome HiCAR | 544 | |
| chr5:176,618,956–176,619,934 | 202.8 kb | Distal (>10kb) Multiome | 328 | |
| chr5:176,630,050–176,630,816 | 213.9 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,646,726–176,648,437 | 230.8 kb | Distal (>10kb) Multiome | 701 | |
| chr5:176,660,849–176,661,318 | 244.5 kb | Distal (>10kb) Multiome | 382 |
Genomic view of the CLTB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.