BST2
bone marrow stromal cell antigen 2 | BST-2, CD317, HM1.24, tetherin

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Member of: DE-12 DE-12.4 Developmental clusters: GC6
Biological processes 43 terms
Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)RNA binding (GO:0003723)apical plasma membrane (GO:0016324)apical plasma membrane (GO:0016324)azurophil granule membrane (GO:0035577)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)cytoplasm (GO:0005737)cytoplasm (GO:0005737)defense response to virus (GO:0051607)defense response to virus (GO:0051607)defense response to virus (GO:0051607)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)innate immune response (GO:0045087)innate immune response (GO:0045087)late endosome (GO:0005770)membrane (GO:0016020)membrane raft (GO:0045121)metalloendopeptidase inhibitor activity (GO:0008191)metalloendopeptidase inhibitor activity (GO:0008191)multivesicular body (GO:0005771)negative regulation of cell growth (GO:0030308)negative regulation of cell migration (GO:0030336)negative regulation of intracellular transport of viral material (GO:1901253)negative regulation of plasmacytoid dendritic cell cytokine production (GO:0002737)negative regulation of viral genome replication (GO:0045071)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of leukocyte proliferation (GO:0070665)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of actin cytoskeleton organization (GO:0032956)response to interferon-alpha (GO:0035455)response to interferon-beta (GO:0035456)response to type II interferon (GO:0034341)response to virus (GO:0009615)
Expression (TPM)
BST2 — as a Regulated Gene

TFs regulating BST2 0 TFs

Transcription factors with Perturb-seq knockdown data for BST2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BST2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BST2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BST2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:17,209,430–17,210,427 195.8 kb Distal (>10kb) Multiome 245
chr19:17,215,005–17,215,979 190.1 kb Distal (>10kb) Multiome 897
chr19:17,225,705–17,226,889 179.2 kb Distal (>10kb) Multiome 870
chr19:17,234,748–17,236,650 169.7 kb Distal (>10kb) Multiome 612
chr19:17,244,882–17,247,104 159.4 kb Distal (>10kb) Multiome 862
chr19:17,247,935–17,248,860 157.0 kb Distal (>10kb) Multiome 588
chr19:17,266,931–17,267,755 138.3 kb Distal (>10kb) Multiome 720
chr19:17,281,537–17,283,120 122.8 kb Distal (>10kb) Multiome 669
chr19:17,292,242–17,293,049 112.9 kb Distal (>10kb) Multiome 513
chr19:17,302,721–17,303,771 102.1 kb Distal (>10kb) Multiome 636
chr19:17,305,286–17,306,514 99.9 kb Distal (>10kb) Multiome 947
chr19:17,309,159–17,310,151 96.1 kb Distal (>10kb) Multiome 741
chr19:17,327,532–17,329,548 77.6 kb Distal (>10kb) Multiome 370
chr19:17,334,287–17,335,052 70.8 kb Distal (>10kb) Multiome 870
chr19:17,336,574–17,338,240 68.1 kb Distal (>10kb) Multiome 924
chr19:17,340,311–17,341,226 64.9 kb Distal (>10kb) Multiome 419
chr19:17,390,414–17,391,521 14.4 kb Distal (>10kb) Multiome 615
chr19:17,394,998–17,395,433 10.3 kb Distal (>10kb) Multiome 403
chr19:17,397,300–17,397,562 8.0 kb Proximal (<10kb) 15
chr19:17,398,863–17,399,537 6.4 kb Proximal (<10kb) Multiome 132
chr19:17,403,087–17,404,355 2.0 kb Proximal (<10kb) Multiome 211
chr19:17,405,595–17,405,760 20 bp At TSS 440
chr19:17,419,503–17,420,821 14.4 kb Distal (>10kb) Multiome 869
chr19:17,424,865–17,425,411 19.6 kb Distal (>10kb) Multiome 328
chr19:17,448,174–17,448,841 43.1 kb Distal (>10kb) Multiome 392
chr19:17,468,858–17,470,905 64.5 kb Distal (>10kb) Multiome 743
chr19:17,488,739–17,489,689 83.6 kb Distal (>10kb) Multiome 381
chr19:17,511,113–17,512,592 106.0 kb Distal (>10kb) Multiome 1021
chr19:17,538,878–17,540,353 134.2 kb Distal (>10kb) Multiome 725
chr19:17,555,194–17,556,523 150.0 kb Distal (>10kb) Multiome 713
chr19:17,576,463–17,577,455 171.4 kb Distal (>10kb) Multiome 236
chr19:17,579,580–17,580,242 174.4 kb Distal (>10kb) Multiome 281
chr19:17,605,468–17,607,009 200.6 kb Distal (>10kb) Multiome 1030
chr19:17,686,280–17,688,656 281.2 kb Distal (>10kb) Multiome 586

Genome Browser

Genomic view of the BST2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:17,199,430 – 17,698,656
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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