The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for PVR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PVR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PVR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:44,356,364–44,357,093 | 287.1 kb | Distal (>10kb) Multiome | 406 | |
| chr19:44,499,680–44,500,955 | 143.3 kb | Distal (>10kb) Multiome | 1007 | |
| chr19:44,643,571–44,644,620 | 97 bp | At TSS Multiome | 710 | |
| chr19:44,747,085–44,747,789 | 103.7 kb | Distal (>10kb) Multiome | 653 | |
| chr19:44,757,112–44,758,480 | 113.6 kb | Distal (>10kb) Multiome | 209 | |
| chr19:44,758,633–44,759,104 | 115.1 kb | Distal (>10kb) Multiome | 80 | |
| chr19:44,770,589–44,771,108 | 126.9 kb | Distal (>10kb) Multiome | 367 | |
| chr19:44,777,671–44,778,314 | 134.1 kb | Distal (>10kb) Multiome | 353 | |
| chr19:44,800,231–44,800,829 | 156.8 kb | Distal (>10kb) Multiome | 508 | |
| chr19:44,807,965–44,809,338 | 164.3 kb | Distal (>10kb) Multiome | 652 | |
| chr19:44,844,448–44,848,668 | 201.0 kb | Distal (>10kb) Multiome | 1047 | |
| chr19:44,890,209–44,891,796 | 247.1 kb | Distal (>10kb) Multiome | 952 | |
| chr19:44,903,686–44,904,241 | 260.0 kb | Distal (>10kb) Multiome | 666 | |
| chr19:44,905,114–44,907,037 | 262.9 kb | Distal (>10kb) Multiome | 645 | |
| chr19:44,913,546–44,915,671 | 271.3 kb | Distal (>10kb) Multiome | 587 | |
| chr19:44,926,693–44,927,388 | 283.4 kb | Distal (>10kb) Multiome | 277 |
Genomic view of the PVR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.