DE-12 ›

DE-12.4

Submodule 13 genes

Interferon response and extracellular matrix regulation

This 13-gene module includes BST2, FEZ1, COL6A2, RMST, and CLTB, with top enriched terms pointing to interferon signaling, type I interferon response, and extracellular matrix organization. No transcription factor knockdown data are available for this module, limiting inference about its regulatory control during ESC-to-DE differentiation.

Key terms: negative regulation of plasmacytoid dendritic cell cytokine production negative regulation of dendritic cell cytokine production regulation of plasmacytoid dendritic cell cytokine production negative regulation of intracellular transport of viral material Notable genes: BST2 FEZ1 COL6A2 RMST CLTB LMCD1-AS1 ENSG00000227681 ENSG00000258561

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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