Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. [provided by Alliance of Genome Resources, Jul 2025]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Cluster | Dir | NES | padj | Bind | OR | padj (bind) |
|---|
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by RCOR2 through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to RCOR2 knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where RCOR2 has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for RCOR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCOR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCOR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,670,776–63,672,118 | 245.5 kb | Distal (>10kb) Multiome | 715 | |
| chr11:63,680,920–63,682,270 | 235.7 kb | Distal (>10kb) Multiome | 869 | |
| chr11:63,761,764–63,765,204 | 153.0 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 149.6 kb | Distal (>10kb) Multiome | 627 | |
| chr11:63,813,022–63,814,238 | 103.7 kb | Distal (>10kb) Multiome | 704 | |
| chr11:63,838,214–63,839,799 | 78.2 kb | Distal (>10kb) Multiome HiCAR | 687 | |
| chr11:63,888,171–63,888,861 | 28.6 kb | Distal (>10kb) Multiome | 565 | |
| chr11:63,909,610–63,910,221 | 7.2 kb | Proximal (<10kb) Multiome | 113 | |
| chr11:63,916,069–63,921,372 | 2.3 kb | Proximal (<10kb) Multiome | 929 | |
| chr11:63,938,087–63,939,846 | 21.6 kb | Distal (>10kb) Multiome | 852 | |
| chr11:63,974,156–63,975,123 | 57.4 kb | Distal (>10kb) Multiome | 918 | |
| chr11:63,986,198–63,987,213 | 69.4 kb | Distal (>10kb) Multiome | 895 | |
| chr11:63,998,533–64,001,109 | 82.3 kb | Distal (>10kb) Multiome | 414 | |
| chr11:64,028,126–64,028,898 | 111.5 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,165,638–64,166,698 | 249.1 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,184,927–64,186,817 | 268.8 kb | Distal (>10kb) Multiome | 1091 |
Genomic view of the RCOR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.