This gene produces a long non-coding RNA that functions in neurogenesis by aiding in the association of Sox2 transcription factor to its target promoters. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for RMST. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMST upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMST, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:97,396,794–97,397,554 | 67.9 kb | Distal (>10kb) Multiome | 136 | |
| chr12:97,412,529–97,413,333 | 52.2 kb | Distal (>10kb) Multiome | 71 | |
| chr12:97,462,696–97,463,509 | 1.6 kb | Proximal (<10kb) | 130 | |
| chr12:97,464,329–97,465,500 | 64 bp | At TSS Multiome | 235 | |
| chr12:97,608,441–97,609,372 | 143.8 kb | Distal (>10kb) Multiome | 222 | |
| chr12:98,397,273–98,398,042 | 932.5 kb | Distal (>10kb) Multiome HiCAR | 455 |
Genomic view of the RMST locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.