This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FEZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FEZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FEZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:125,224,246–125,224,764 | 368.0 kb | Distal (>10kb) Multiome | 63 | |
| chr11:125,239,981–125,240,709 | 352.2 kb | Distal (>10kb) Multiome | 103 | |
| chr11:125,262,828–125,263,907 | 329.1 kb | Distal (>10kb) Multiome | 339 | |
| chr11:125,330,306–125,331,087 | 261.8 kb | Distal (>10kb) Multiome | 104 | |
| chr11:125,369,857–125,372,110 | 222.3 kb | Distal (>10kb) Multiome | 226 | |
| chr11:125,404,667–125,405,169 | 187.6 kb | Distal (>10kb) Multiome | 273 | |
| chr11:125,433,337–125,433,944 | 158.9 kb | Distal (>10kb) Multiome | 170 | |
| chr11:125,443,557–125,444,361 | 148.6 kb | Distal (>10kb) Multiome | 142 | |
| chr11:125,495,125–125,496,641 | 96.3 kb | Distal (>10kb) Multiome | 422 | |
| chr11:125,505,583–125,506,532 | 86.6 kb | Distal (>10kb) Multiome | 40 | |
| chr11:125,509,289–125,509,972 | 83.0 kb | Distal (>10kb) Multiome | 165 | |
| chr11:125,568,984–125,569,972 | 23.2 kb | Distal (>10kb) Multiome | 796 | |
| chr11:125,591,812–125,593,372 | 141 bp | At TSS Multiome | 902 | |
| chr11:125,625,323–125,626,856 | 33.5 kb | Distal (>10kb) Multiome | 1108 | |
| chr11:125,886,970–125,888,478 | 295.2 kb | Distal (>10kb) Multiome HiCAR | 823 |
Genomic view of the FEZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.