Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in nervous system development and regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by ADNP2 through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to ADNP2 knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where ADNP2 has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for ADNP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADNP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADNP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:79,950,747–79,952,381 | 157.6 kb | Distal (>10kb) Multiome | 606 | |
| chr18:79,960,055–79,960,750 | 148.8 kb | Distal (>10kb) Multiome | 94 | |
| chr18:79,964,253–79,964,855 | 144.7 kb | Distal (>10kb) Multiome | 536 | |
| chr18:79,988,046–79,989,235 | 120.7 kb | Distal (>10kb) Multiome | 832 | |
| chr18:80,033,036–80,034,844 | 75.1 kb | Distal (>10kb) Multiome | 863 | |
| chr18:80,104,360–80,104,725 | 4.5 kb | Proximal (<10kb) | 159 | |
| chr18:80,108,658–80,110,068 | 177 bp | At TSS Multiome | 673 | |
| chr18:80,119,162–80,119,666 | 10.1 kb | Distal (>10kb) Multiome | 42 | |
| chr18:80,147,532–80,148,374 | 38.6 kb | Distal (>10kb) Multiome | 357 | |
| chr18:80,245,958–80,247,961 | 137.2 kb | Distal (>10kb) Multiome | 405 |
Genomic view of the ADNP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.