Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
Transcription factors with Perturb-seq knockdown data for SORD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SORD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SORD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:44,728,448–44,729,627 | 294.2 kb | Distal (>10kb) Multiome | 787 | |
| chr15:45,022,392–45,023,983 | 70 bp | At TSS Multiome | 755 | |
| chr15:45,035,231–45,035,688 | 12.2 kb | Distal (>10kb) Multiome | 12 | |
| chr15:45,048,481–45,049,541 | 25.8 kb | Distal (>10kb) Multiome | 334 | |
| chr15:45,112,418–45,113,157 | 89.7 kb | Distal (>10kb) Multiome | 97 | |
| chr15:45,117,740–45,118,422 | 95.0 kb | Distal (>10kb) Multiome | 509 | |
| chr15:45,129,270–45,130,268 | 106.7 kb | Distal (>10kb) Multiome | 118 | |
| chr15:45,162,761–45,163,531 | 140.0 kb | Distal (>10kb) Multiome | 392 | |
| chr15:45,166,561–45,167,807 | 144.2 kb | Distal (>10kb) Multiome | 718 | |
| chr15:45,186,761–45,188,736 | 164.8 kb | Distal (>10kb) Multiome | 506 | |
| chr15:45,198,102–45,201,508 | 177.3 kb | Distal (>10kb) Multiome | 1170 | |
| chr15:45,224,322–45,226,044 | 201.7 kb | Distal (>10kb) Multiome | 242 | |
| chr15:45,278,955–45,279,690 | 256.1 kb | Distal (>10kb) Multiome | 613 |
Genomic view of the SORD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.