ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for ATF7IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATF7IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATF7IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:14,240,179–14,240,896 | 125.2 kb | Distal (>10kb) Multiome | 309 | |
| chr12:14,257,545–14,258,843 | 107.8 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr12:14,259,910–14,261,390 | 105.5 kb | Distal (>10kb) Multiome HiCAR | 592 | |
| chr12:14,267,660–14,268,650 | 97.5 kb | Distal (>10kb) Multiome HiCAR | 60 | |
| chr12:14,365,285–14,366,175 | 62 bp | At TSS Multiome | 680 | |
| chr12:14,567,263–14,568,383 | 202.1 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the ATF7IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.