DE-12 ›

DE-12.1

Submodule 43 genes

Vesicle transport and cell adhesion regulation

This 43-gene module includes KIT, PDPN, PVR, and CDH3, with enrichment in regulation of vesicle-mediated transport. Knockdown of ZNF644 and SMARCC1 activates this module. Knockdown of ADNP2, SETDB1, and CHAMP1 represses this module.

Key terms: regulation of vesicle-mediated transport vesicle-mediated transport positive regulation of clathrin-dependent endocytosis positive regulation of receptor-mediated endocytosis Notable genes: KIT PDPN PVR CDH3 DAB2 WASL RBFOX1 KAT7 Top TFs: ADNP2 SETDB1 CHAMP1 DNMT1 RCOR2

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (43)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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