Transcription factors with Perturb-seq knockdown data for DLEU1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLEU1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLEU1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:49,791,339–49,793,749 | 289.3 kb | Distal (>10kb) Multiome | 930 | |
| chr13:49,847,783–49,848,275 | 234.1 kb | Distal (>10kb) Multiome | 505 | |
| chr13:49,935,563–49,937,380 | 145.8 kb | Distal (>10kb) Multiome | 924 | |
| chr13:49,995,900–49,997,790 | 85.2 kb | Distal (>10kb) Multiome | 906 | |
| chr13:50,080,906–50,083,082 | 45 bp | At TSS Multiome | 885 | |
| chr13:50,123,622–50,126,557 | 42.3 kb | Distal (>10kb) Multiome | 1075 | |
| chr13:50,129,633–50,130,893 | 48.0 kb | Distal (>10kb) Multiome | 289 | |
| chr13:50,779,449–50,780,341 | 697.7 kb | Distal (>10kb) Multiome HiCAR | 141 | |
| chr13:50,909,544–50,910,786 | 827.7 kb | Distal (>10kb) Multiome HiCAR | 827 |
Genomic view of the DLEU1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.